1 NM-PP1
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- $50 - $3780
- Product name: 1 NM-PP1
- CAS: 221244-14-0
- MF: C20H21N5
- MW: 331.41
- EINECS:
- MDL Number:MFCD03425470
- Synonyms:4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-1-TERT-BUYTL-3-(1-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE;1 NM-PP1;MUTANT KINASES INHIBITOR II;PP1 ANALOG II;1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1-tert-Butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-D]pyrimidin-4-amine;Chebi:52309
33 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1MG
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product number1408AH
- Product description4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
- Packaging10mg
- Price$117
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA106671
- Product description1NM-PP1(PP1AnalogII) 98+%
- Packaging5mg
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA106671
- Product description1NM-PP1(PP1AnalogII) 98+%
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001448
- Product description4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)PYRAZOLO-[3,4-D]PYRIMIDINE 95.00%
- Packaging1MG
- Price$211.05
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001448
- Product description4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)PYRAZOLO-[3,4-D]PYRIMIDINE 95.00%
- Packaging5MG
- Price$495.74
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1299
- Product description1-NM-PP1
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1299
- Product description1-NM-PP1
- Packaging10mM(in 1mL DMSO)
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1299
- Product description1-NM-PP1
- Packaging10mg
- Price$143
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1299
- Product description1-NM-PP1
- Packaging25mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1299
- Product description1-NM-PP1
- Packaging50mg
- Price$551
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS014704
- Product description1NM-PP1(PP1AnalogII) ≥98%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS014704
- Product description1NM-PP1(PP1AnalogII) ≥98%
- Packaging10mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1892
- Product description1-NM-PP1 99%
- Packaging5mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA10330
- Product description4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
- Packaging10mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA10330
- Product description4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
- Packaging25mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA10330
- Product description4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
- Packaging50mg
- Price$150
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1408AH | 4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine | 10mg | $117 | 2021-12-16 | Buy |
| Ambeed | A106671 | 1NM-PP1(PP1AnalogII) 98+% | 5mg | $73 | 2021-12-16 | Buy |
| Ambeed | A106671 | 1NM-PP1(PP1AnalogII) 98+% | 10mg | $125 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001448 | 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)PYRAZOLO-[3,4-D]PYRIMIDINE 95.00% | 1MG | $211.05 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001448 | 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)PYRAZOLO-[3,4-D]PYRIMIDINE 95.00% | 5MG | $495.74 | 2021-12-16 | Buy |
| ApexBio Technology | B1299 | 1-NM-PP1 | 5mg | $90 | 2021-12-16 | Buy |
| ApexBio Technology | B1299 | 1-NM-PP1 | 10mM(in 1mL DMSO) | $105 | 2021-12-16 | Buy |
| ApexBio Technology | B1299 | 1-NM-PP1 | 10mg | $143 | 2021-12-16 | Buy |
| ApexBio Technology | B1299 | 1-NM-PP1 | 25mg | $333 | 2021-12-16 | Buy |
| ApexBio Technology | B1299 | 1-NM-PP1 | 50mg | $551 | 2021-12-16 | Buy |
| Arctom | AS014704 | 1NM-PP1(PP1AnalogII) ≥98% | 5mg | $72 | 2021-12-16 | Buy |
| Arctom | AS014704 | 1NM-PP1(PP1AnalogII) ≥98% | 10mg | $124 | 2021-12-16 | Buy |
| Axon Medchem | Axon1892 | 1-NM-PP1 99% | 5mg | $104.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA10330 | 4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine | 10mg | $50 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA10330 | 4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine | 25mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA10330 | 4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine | 50mg | $150 | 2021-12-16 | Buy |
Properties
Melting point :175-176°C
Boiling point :545.7±45.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Chloroform (Slightly), Methanol (Slightly, Heated)
pka :4.50±0.30(Predicted)
form :White solid
color :White to Beige
Boiling point :545.7±45.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Chloroform (Slightly), Methanol (Slightly, Heated)
pka :4.50±0.30(Predicted)
form :White solid
color :White to Beige
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become ‘a(chǎn)nalog sensitive’ (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 μM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.More related product prices
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