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鹽酸酚芐明

鹽酸酚芐明

中文名稱鹽酸酚芐明
中文同義詞N-(1-甲基-2-苯氧乙基)-N-(2-氯乙基)苯甲胺鹽酸鹽;鹽酸苯氧芐胺;鹽酸酚芐明;苯芐胺;苯氧芐胺;酚芐胺;酚芐明鹽酸鹽;N-(2-氯乙基)-N-(1-甲基-2-苯氧乙基)芐胺鹽酸鹽
英文名稱Phenoxybenzamine hydrochloride
英文同義詞benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)aminehydrochloride;dibenzyran;n-phenoxyisopropyl-n-benzyl-beta-chloroethylaminehydrochloride;phenoxybenzamidehydrochloride;BENZENE METHANAMINE HYDROCHLORIDE;DIBENZYLINE HYDROCHLORIDE;N-PHENOXYISOPROPYL-N-BENZYL-2-CHLOROETHYLAMINE HYDROCHLORIDE;PHENOXYBENZAMINE HYDROCHLORIDE
CAS號(hào)63-92-3
分子式C18H22ClNO.ClH
分子量340.29
EINECS號(hào)200-569-7
相關(guān)類別原料藥;醫(yī)藥原料;G蛋白偶聯(lián)受體&G蛋白;中間體;小分子抑制劑;醫(yī)用原料;細(xì)胞生物學(xué)試劑;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;DIBENZYLINE;科研試劑;原料;化學(xué)試劑;日用化學(xué)品;醫(yī)藥原料藥
Mol文件63-92-3.mol
結(jié)構(gòu)式鹽酸酚芐明 結(jié)構(gòu)式

鹽酸酚芐明 性質(zhì)

熔點(diǎn)137.5°C
儲(chǔ)存條件15-25°C
溶解度溶于乙醇、DMSO、二甲基甲酰胺(DMF)等有機(jī)溶劑。
形態(tài)粉末
酸度系數(shù)(pKa)pKa 4.4 (Uncertain)
顏色白色
水溶解性<0.01 g/100 mL at 18.5 ºC
Merck14,7256
穩(wěn)定性自購(gòu)買之日起 2 年內(nèi)保持穩(wěn)定。 DMSO 或蒸餾水中的溶液可在 -20°C 下儲(chǔ)存長(zhǎng)達(dá) 3 個(gè)月。
CAS 數(shù)據(jù)庫(kù)63-92-3(CAS DataBase Reference)
(IARC)致癌物分類2B (Vol. 24, Sup 7) 1987
EPA化學(xué)物質(zhì)信息N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3)

鹽酸酚芐明 用途與合成方法

Phenoxybenzamine HCl (NSC 37448, NCI-c01661)是一種非選擇性,不可逆α受體拮抗劑,IC50為550 nM。
TargetValue
α-adrenergic receptor

The IC 50 (100 nM) derived from the blockade of [ 3 H]yohimbine binding by Phenoxybenzamine hydrochloride is significantly less than the IC 50 (550 nM) for the corresponding reversal by Phenoxybenzamine hydrochloride of the effects of norepinephrine on cyclic AMP accumulation. Phenoxybenzamine hydrochloride (50 nM) in conbination with Phenoxybenzamine hydrochloridetolamine (1000 nM) enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with pretreatment with Phenoxybenzamine hydrochloride (50 nM) alone in endothelium-intact aortae. Combined treatment with either dexmedetomidine (300 or 1000 nM) and Phenoxybenzamine hydrochloride (50 nM) or Phenoxybenzamine hydrochloridetolamine (1000 nM) and Phenoxybenzamine hydrochloride (50 nM) enhance Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with Phenoxybenzamine hydrochloride alone (50 nM). In addition, combined treatment with Phenoxybenzamine hydrochloridetolamine and Phenoxybenzamine hydrochloride enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with dexmedetomidine (1000 nM) and Phenoxybenzamine hydrochloride combined treatment. ?Combined treatment with high concentrations of dexmedetomidine (1000 nM) and Phenoxybenzamine hydrochloride enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with combined treatment with low concentrations of dexmedetomidine (300 nM) and Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride (0.1-100 μM) inhibits glioma proliferation, migration, and invasion and suppresses the tumorigenesis capacity. Phenoxybenzamine hydrochloride also inhibits self-renewal of glioma stem-like cells. Phenoxybenzamine hydrochloride activates LINGO-1 and inhibits the TrkB-Akt pathway. Phenoxybenzamine hydrochloride (0.1 μM-1 mM) preserves primary neurons within the CA1, CA3 and dentate gyrus and produces a robust neuroprotective effect, and prevents neuronal death from OGD in all regions of the hippocampus when delivered at 2, 4, and 8 h post-OGD at 100 μM.

Phenoxybenzamine hydrochloride (20 nM, s.c.) effectively suppresses the tumorigenesis of glioma cells in mice and the cell density in Phenoxybenzamine hydrochloride-U87MG xenografts decreases significantly. Phenoxybenzamine hydrochloride (1 mg/kg, i.v.) treated rats shows significant improvements in NSS and foot fault scoring.

化學(xué)性質(zhì) 
白色結(jié)晶性粉末。熔點(diǎn)137.5-140℃。溶于乙醇、氯仿、丙二醇,略溶于苯,微溶于冷水。其游離堿熔點(diǎn)38-40℃,溶于苯。
用途 
α-受體陰斷劑,選擇性強(qiáng),作用持久。主要用于嗜鉻細(xì)胞瘤、雷諾氏綜合癥、物足發(fā)紺及凍瘡后遺癥。
用途 
用于治療嗜鉻細(xì)胞瘤、雷諾氏綜合癥、手足發(fā)紺及凍瘡后遺癥等

安全信息

危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼22-40
安全說(shuō)明22-36/37/39-45
WGK Germany3
RTECS號(hào)DP3750000
海關(guān)編碼2922299000

MSDS信息

鹽酸酚芐明 化學(xué)藥品說(shuō)明書

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-B0431A鹽酸酚芐明
Phenoxybenzamine hydrochloride
63-92-3500mg300元
2024/11/08S2499鹽酸酚芐明
Phenoxybenzamine HCl
63-92-350mg788.04元

鹽酸酚芐明 上下游產(chǎn)品信息

"鹽酸酚芐明"相關(guān)產(chǎn)品信息
甲磺隆 苯甲胺鹽酸鹽 二苯甲胺 三甲胺鹽酸鹽 1-金剛烷乙胺 甲基纖維素 芐嘧磺隆 苯甲醇 α-氨基乙苯 鹽酸拓?fù)涮婵?/a> 尼泊金甲酯 乙酸芐酯 羥乙基甲基纖維素 芐胺 甲氧芐啶 甲醇 鹽酸苯海拉明 丙烯酸甲酯
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