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ChemicalBook >> CAS DataBase List >> Regorafenib

Regorafenib

Regorafenib price.
  • $25 - $1208.7
  • Product name: Regorafenib
  • CAS: 755037-03-7
  • MF: C21H15ClF4N4O3
  • MW: 482.82
  • EINECS:815-051-1
  • MDL Number:MFCD16038047
  • Synonyms:4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide;REGORAFENIB BAY 73-4506 BAYER HEALTHCARE (SEE ALSO COLORECTAL, LUNG, STOMACH) PHASE II(REGORAFENIB) PHARMACEUTICALS (888) 842-2937WAYNE, NJ;4-[4-[[[[4-Chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]-3-fluorophenoxy]-N-Methyl-2-pyridinecarboxaMide;4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3- fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide;regorafinib;Regafenib;Reggae sorafenib;Regorafenib C3X-1410
38 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • DC Chemicals
  • TCI Chemical
  • TRC
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 1unit
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 2x50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3623-M005
  • Product descriptionRegorafenib ≥98%(HPLC)
  • Packaging5mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1169
  • Product descriptionRegorafenib
  • Packaging1mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1169
  • Product descriptionRegorafenib
  • Packaging10mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1169
  • Product descriptionRegorafenib
  • Packaging100mg
  • Price$1065
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000417
  • Product descriptionBAY-73-4506 95.00%
  • Packaging1MG
  • Price$426
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8236
  • Product descriptionRegorafenib
  • Packaging200mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8236
  • Product descriptionRegorafenib
  • Packaging100mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8236
  • Product descriptionRegorafenib
  • Packaging50mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8236
  • Product descriptionRegorafenib
  • Packaging10mM(in 1mL DMSO)
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8236
  • Product descriptionRegorafenib
  • Packaging10mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8236
  • Product descriptionRegorafenib
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60043
  • Product descriptionRegorafenib(BAY73-4506) ≥98%
  • Packaging20mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1678
  • Product descriptionRegorafenib-BAY73-4506|Stivarga 98%
  • Packaging5mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1678
  • Product descriptionRegorafenib-BAY73-4506|Stivarga 98%
  • Packaging2x50mg
  • Price$506
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546157
  • Product descriptionRegorafenib >98%
  • Packaging5mg
  • Price$154.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546157
  • Product descriptionRegorafenib >98%
  • Packaging25mg
  • Price$382.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3623-M005 Regorafenib ≥98%(HPLC) 5mg $25 2021-12-16 Buy
AK Scientific SYN1169 Regorafenib 1mg $100 2021-12-16 Buy
AK Scientific SYN1169 Regorafenib 10mg $220 2021-12-16 Buy
AK Scientific SYN1169 Regorafenib 100mg $1065 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000417 BAY-73-4506 95.00% 1MG $426 2021-12-16 Buy
ApexBio Technology A8236 Regorafenib 200mg $250 2021-12-16 Buy
ApexBio Technology A8236 Regorafenib 100mg $160 2021-12-16 Buy
ApexBio Technology A8236 Regorafenib 50mg $100 2021-12-16 Buy
ApexBio Technology A8236 Regorafenib 10mM(in 1mL DMSO) $70 2021-12-16 Buy
ApexBio Technology A8236 Regorafenib 10mg $40 2021-12-16 Buy
ApexBio Technology A8236 Regorafenib 1unit $28 2021-12-16 Buy
Arctom CFN60043 Regorafenib(BAY73-4506) ≥98% 20mg $118 2021-12-16 Buy
Axon Medchem Axon1678 Regorafenib-BAY73-4506|Stivarga 98% 5mg $77 2021-12-16 Buy
Axon Medchem Axon1678 Regorafenib-BAY73-4506|Stivarga 98% 2x50mg $506 2021-12-16 Buy
Biorbyt Ltd orb546157 Regorafenib >98% 5mg $154.7 2021-12-16 Buy
Biorbyt Ltd orb546157 Regorafenib >98% 25mg $382.5 2021-12-16 Buy

Properties

Melting point :206.0 to 210.0 °C
Boiling point :513.4±50.0 °C(Predicted)
Density :1.491±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :12.04±0.70(Predicted)
form :White powder.
color :Pale Pink to Light Pink
CAS DataBase Reference :755037-03-7

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Regorafenib is an orally-bioavailable multi-kinase inhibitor that is structurally related to sorafenib (BAY 43-9006; ), another multi-kinase inhibitor with applications in cancer. Regorafenib inhibits c-Raf, B-Raf, VEGFR1, VEGFR2, VEGFR3, Tie2, PDGFRβ, FGFR1, c-Kit, and RET with IC50 values of 2.5, 28, 13, 4.2, 46, 311, 22, 202, 7, and 1.5 nM, respectively, as well as other kinases. It also inhibits soluble epoxide hydrolase (IC50 = 0.5 nM). Regorafenib has value against a range of cancers, including advanced colorectal cancer.

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