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ChemicalBook >> CAS DataBase List >> Afatinib dimaleate

Afatinib dimaleate

Afatinib dimaleate price.
  • $41 - $1841
  • Product name: Afatinib dimaleate
  • CAS: 850140-73-7
  • MF: C28H29ClFN5O7
  • MW: 602.02
  • EINECS:810-416-1
  • MDL Number:MFCD28969755
  • Synonyms:BIBW2992 DiMaleate;BIBW2992-MA2;Afatinib (diMaleate), BIBW2992;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-, (2Z)-2-butenedioate (1:2);(2E)-N-(4-[(3-chloro-4-fluorophenyl)aMino]-7-{[(3S);Afatinib double Maleate;Afatinib (BIBW2992) Dimaleate;N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-(2E)-2-butenamide,(2Z)-2-butenedioate (1:2)
28 prices
Selected condition:
Brand
  • A1 Biochem Labs
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
Package
  • 5mg
  • 50mg
  • 10mg
  • 10
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 50
  • 10mM(in 1mL DMSO)
  • 5G
  • ManufacturerA1 Biochem Labs
  • Product number6566399
  • Product descriptionAfatinib(dimaleate) 98%
  • Packaging5G
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3423AH
  • Product descriptionAfatinibDimaleate
  • Packaging250mg
  • Price$159
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3145
  • Product descriptionAfatinibdimaleate
  • Packaging5mg
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3145
  • Product descriptionAfatinibdimaleate
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3145
  • Product descriptionAfatinibdimaleate
  • Packaging10mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3145
  • Product descriptionAfatinibdimaleate
  • Packaging50mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146151
  • Product descriptionBIBW2992-MA2 (Afatinib dimaleate) >98%
  • Packaging100mg
  • Price$414.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146151
  • Product descriptionBIBW2992-MA2 (Afatinib dimaleate) >98%
  • Packaging250mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146151
  • Product descriptionBIBW2992-MA2 (Afatinib dimaleate) >98%
  • Packaging1g
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBA162012
  • Product descriptionAfatinib dimaleate
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBA162012
  • Product descriptionAfatinib dimaleate
  • Packaging50mg
  • Price$262.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21567
  • Product descriptionAfatinib (maleate) ≥95%
  • Packaging250mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21567
  • Product descriptionAfatinib (maleate) ≥95%
  • Packaging500mg
  • Price$176
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21567
  • Product descriptionAfatinib (maleate) ≥95%
  • Packaging1g
  • Price$330
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21567
  • Product descriptionAfatinib (maleate) ≥95%
  • Packaging5g
  • Price$1002
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM142622
  • Product description(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamidedimaleate 98%
  • Packaging250mg
  • Price$186
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
A1 Biochem Labs 6566399 Afatinib(dimaleate) 98% 5G $450 2021-12-16 Buy
AK Scientific 3423AH AfatinibDimaleate 250mg $159 2021-12-16 Buy
ApexBio Technology A3145 Afatinibdimaleate 5mg $41 2021-12-16 Buy
ApexBio Technology A3145 Afatinibdimaleate 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A3145 Afatinibdimaleate 10mg $68 2021-12-16 Buy
ApexBio Technology A3145 Afatinibdimaleate 50mg $97 2021-12-16 Buy
Biorbyt Ltd orb146151 BIBW2992-MA2 (Afatinib dimaleate) >98% 100mg $414.8 2021-12-16 Buy
Biorbyt Ltd orb146151 BIBW2992-MA2 (Afatinib dimaleate) >98% 250mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb146151 BIBW2992-MA2 (Afatinib dimaleate) >98% 1g $1208.7 2021-12-16 Buy
Biosynth Carbosynth BA162012 Afatinib dimaleate 10mg $75 2021-12-16 Buy
Biosynth Carbosynth BA162012 Afatinib dimaleate 50mg $262.5 2021-12-16 Buy
Cayman Chemical 21567 Afatinib (maleate) ≥95% 250mg $93 2024-03-01 Buy
Cayman Chemical 21567 Afatinib (maleate) ≥95% 500mg $176 2024-03-01 Buy
Cayman Chemical 21567 Afatinib (maleate) ≥95% 1g $330 2024-03-01 Buy
Cayman Chemical 21567 Afatinib (maleate) ≥95% 5g $1002 2024-03-01 Buy
Chemenu CM142622 (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamidedimaleate 98% 250mg $186 2021-12-16 Buy

Properties

Melting point :>237oC (dec.)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Pale Yellow
InChIKey :LIENDGDDWJRJLO-LBXKZPGENA-N
SMILES :C(/C(=O)O)=C/C(=O)O.N(C1C=CC(F)=C(Cl)C=1)C1=NC=NC2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC1=2 |&1:25,r|

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Afatinib dimaleate was approved by the U.S. Food and Drug Administration (FDA) in 2013 for the treatment of non-small cell lung cancer (NSCLC). Specifically, it was approved for patients presenting with metastatic NSCLC tumors which contain epidermal growth factor receptor (EGFR) exon deletions or exon 21 mutations. Afatinib dimaleate is a covalent inhibitor of ErbB tyrosine kinases (tyk), which downregulates ErbB signaling by irreversible binding of EGFR tyk binding sites. While no manufacturing route has been disclosed to date, the most scalable published route likely derives from two Boehringer Ingelheim patents.