Pevonedistat
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- $49 - $4735.5
- Product name: Pevonedistat
- CAS: 905579-51-3
- MF: C21H25N5O4S
- MW: 443.52
- EINECS:
- MDL Number:MFCD17215201
- Synonyms:((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)aMino)-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-2-hydroxycyclopentyl)Methyl sulfaMate;[(1S,2S,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]aMino}-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-2-hydroxycyclopentyl]Methyl sulfaMate;Pevonedistat;MLN4924 (Pevonedistat);Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimi;Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester;CS-821;TAK-924
33 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
Package
- 1mg
- 2mg
- 5mg
- 2x5mg
- 10
- 10MG
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 200mg
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberAG-CS1-0103-M001
- Product descriptionMLN4924[NAEInhibitor]Solution ≥99%(HPLC)
- Packaging1mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5699
- Product descriptionMLN4924
- Packaging100mg
- Price$1660
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000406
- Product descriptionMLN-4924 95.00%
- Packaging1MG
- Price$1097.25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000406
- Product descriptionMLN-4924 95.00%
- Packaging10MG
- Price$4735.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1036
- Product descriptionMLN4924
- Packaging10mM(in 1mL DMSO)
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1036
- Product descriptionMLN4924
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1036
- Product descriptionMLN4924
- Packaging10mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1036
- Product descriptionMLN4924
- Packaging50mg
- Price$580
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1036
- Product descriptionMLN4924
- Packaging100mg
- Price$950
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2038
- Product descriptionMLN4924-Pevonedistat 99%
- Packaging2x5mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM16807
- Product descriptionMLN 4924
- Packaging1mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM16807
- Product descriptionMLN 4924
- Packaging2mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM16807
- Product descriptionMLN 4924
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM16807
- Product descriptionMLN 4924
- Packaging10mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM16807
- Product descriptionMLN 4924
- Packaging25mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15217
- Product descriptionMLN4924 ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CS1-0103-M001 | MLN4924[NAEInhibitor]Solution ≥99%(HPLC) | 1mg | $210 | 2021-12-16 | Buy |
| AK Scientific | SYN5699 | MLN4924 | 100mg | $1660 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000406 | MLN-4924 95.00% | 1MG | $1097.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000406 | MLN-4924 95.00% | 10MG | $4735.5 | 2021-12-16 | Buy |
| ApexBio Technology | B1036 | MLN4924 | 10mM(in 1mL DMSO) | $120 | 2021-12-16 | Buy |
| ApexBio Technology | B1036 | MLN4924 | 5mg | $130 | 2021-12-16 | Buy |
| ApexBio Technology | B1036 | MLN4924 | 10mg | $210 | 2021-12-16 | Buy |
| ApexBio Technology | B1036 | MLN4924 | 50mg | $580 | 2021-12-16 | Buy |
| ApexBio Technology | B1036 | MLN4924 | 100mg | $950 | 2021-12-16 | Buy |
| Axon Medchem | Axon2038 | MLN4924-Pevonedistat 99% | 2x5mg | $220 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM16807 | MLN 4924 | 1mg | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM16807 | MLN 4924 | 2mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM16807 | MLN 4924 | 5mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM16807 | MLN 4924 | 10mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM16807 | MLN 4924 | 25mg | $500 | 2021-12-16 | Buy |
| Cayman Chemical | 15217 | MLN4924 ≥98% | 1mg | $49 | 2024-03-01 | Buy |
Properties
Melting point :161-163°C
Boiling point :721.0±70.0 °C(Predicted)
Density :1.62
storage temp. :-20°C Freezer
solubility :Soluble in DMSO (up to 10 mg/ml).
form :solid
pka :9.35±0.70(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :MPUQHZXIXSTTDU-QXGSTGNESA-N
SMILES :S(N)(OC[C@@H]1C[C@@H](N2C3C(C=C2)=C(N[C@@H]2C4=C(C=CC=C4)CC2)N=CN=3)C[C@@H]1O)(=O)=O
Boiling point :721.0±70.0 °C(Predicted)
Density :1.62
storage temp. :-20°C Freezer
solubility :Soluble in DMSO (up to 10 mg/ml).
form :solid
pka :9.35±0.70(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :MPUQHZXIXSTTDU-QXGSTGNESA-N
SMILES :S(N)(OC[C@@H]1C[C@@H](N2C3C(C=C2)=C(N[C@@H]2C4=C(C=CC=C4)CC2)N=CN=3)C[C@@H]1O)(=O)=O
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates with roles relevant to cellular processes important for cancer cell survival. Neddylation of CRLs is initiated by NEDD8-activating enzyme (NAE), which has become a novel target in cancer therapeutic research. MLN4924 is an analog of adenosine 5’-monophosphate that selectively inhibits NAE (IC50 = 4.7 nM). At much higher concentrations, MLN4924 inhibits the related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 values of 1.5 and 8.2 μM, respectively. At 0.3 μM, MLN4924 has been shown to disrupt CRL-mediated protein turnover leading to apoptosis in HCT-116 cells by deregulating S-phase DNA synthesis. In vivo, 30-60 mg/kg MLN4924 dose-dependently suppresses the growth of human tumor xenografts in mice.More related product prices
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