PD 173074
- $28 - $1647
- Product name: PD 173074
- CAS: 219580-11-7
- MF: C28H41N7O3
- MW: 523.67
- EINECS:
- MDL Number:MFCD08705327
- Synonyms:n-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-n'-(1,1-dimethylethyl)urea;N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d ]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-;PD173074/PD-173074;1-(tert-butyl)-3-(2-((4-(diethylaMino)butyl)aMino)-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)urea;1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-;Urea, N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-;PD176074;N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD 173074
38 prices
Selected condition:
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 1MG
- 1unit
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 10mM(in 1mL DMSO)
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7486
- Product descriptionPD 173074
- Packaging1g
- Price$1491
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150425
- Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
- Packaging5mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150425
- Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
- Packaging10mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150425
- Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
- Packaging50mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150425
- Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
- Packaging100mg
- Price$136
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150425
- Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
- Packaging250mg
- Price$262
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150425
- Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
- Packaging1g
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000180
- Product descriptionPD 173074 95.00%
- Packaging10MG
- Price$693.92
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000180
- Product descriptionPD 173074 95.00%
- Packaging1MG
- Price$166.95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8253
- Product descriptionPD 173074
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8253
- Product descriptionPD 173074
- Packaging10mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8253
- Product descriptionPD 173074
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8253
- Product descriptionPD 173074
- Packaging50mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60135
- Product descriptionPD 173074
- Packaging10mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13032
- Product descriptionPD 173074 ≥98%
- Packaging5mg
- Price$39
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13032
- Product descriptionPD 173074 ≥98%
- Packaging10mg
- Price$74
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | X7486 | PD 173074 | 1g | $1491 | 2021-12-16 | Buy |
Ambeed | A150425 | 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% | 5mg | $45 | 2021-12-16 | Buy |
Ambeed | A150425 | 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% | 10mg | $58 | 2021-12-16 | Buy |
Ambeed | A150425 | 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% | 50mg | $105 | 2021-12-16 | Buy |
Ambeed | A150425 | 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% | 100mg | $136 | 2021-12-16 | Buy |
Ambeed | A150425 | 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% | 250mg | $262 | 2021-12-16 | Buy |
Ambeed | A150425 | 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% | 1g | $650 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000180 | PD 173074 95.00% | 10MG | $693.92 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000180 | PD 173074 95.00% | 1MG | $166.95 | 2021-12-16 | Buy |
ApexBio Technology | A8253 | PD 173074 | 1unit | $28 | 2021-12-16 | Buy |
ApexBio Technology | A8253 | PD 173074 | 10mg | $50 | 2021-12-16 | Buy |
ApexBio Technology | A8253 | PD 173074 | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
ApexBio Technology | A8253 | PD 173074 | 50mg | $140 | 2021-12-16 | Buy |
Arctom | CFN60135 | PD 173074 | 10mg | $118 | 2021-12-16 | Buy |
Cayman Chemical | 13032 | PD 173074 ≥98% | 5mg | $39 | 2024-03-01 | Buy |
Cayman Chemical | 13032 | PD 173074 ≥98% | 10mg | $74 | 2024-03-01 | Buy |
Properties
Melting point :82-85°C
Density :1.163
storage temp. :2-8°C
solubility :DMSO: 21 mg/mL
form :solid
pka :10.12±0.43(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Density :1.163
storage temp. :2-8°C
solubility :DMSO: 21 mg/mL
form :solid
pka :10.12±0.43(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM. For comparison, it weakly inhibits PDGFR and c-Src (IC50 = 17.6 and 19.8 μM, respectively) and has no effect on EGFR, InsR, MEK, or PKC. PD 173074 also prevents signaling, at nanomolar levels, through FGFR2-5. Inhibition of FGFR signaling using PD 173074, impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation.More related product prices
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