CHIR-99021
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- $28 - $4070
- Product name: CHIR-99021
- CAS: 252917-06-9
- MF: C22H18Cl2N8
- MW: 465.34
- EINECS:809-015-4
- MDL Number:MFCD11846251
- Synonyms:6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile;6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile;CHIR-99021;GSK-3 Inhibitor XVI;3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino];CT 99021(CHIR 99021);6-[2-[4-(2,4-Dichlorophenyl)-5-(4-Methyl-1H-iMidazol-2-yl)pyriMidin-2-ylaMino]ethylaMino]pyridine-3-;CHIR 99021(CT 99021)
66 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 1unit
- 2mg
- 5mg
- 10mg
- 25mg
- 2x25mg
- 50
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5163
- Product descriptionCHIR 99021
- Packaging50mg
- Price$405
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA133052
- Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
- Packaging2mg
- Price$31
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA133052
- Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
- Packaging5mg
- Price$54
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA133052
- Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
- Packaging10mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA133052
- Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
- Packaging25mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA133052
- Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
- Packaging50mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA133052
- Product description6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+%
- Packaging250mg
- Price$206
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3011
- Product descriptionCHIR-99021(CT99021)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3011
- Product descriptionCHIR-99021(CT99021)
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3011
- Product descriptionCHIR-99021(CT99021)
- Packaging10mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0014
- Product descriptionCHIR 99021
- Packaging2mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0014
- Product descriptionCHIR 99021
- Packaging5mg
- Price$211
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0014
- Product descriptionCHIR 99021
- Packaging10mg
- Price$305
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS445836
- Product descriptionCHIR 99021 ≥98%
- Packaging2mg
- Price$31
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS445836
- Product descriptionCHIR 99021 ≥98%
- Packaging5mg
- Price$53
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS445836
- Product descriptionCHIR 99021 ≥98%
- Packaging10mg
- Price$78
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5163 | CHIR 99021 | 50mg | $405 | 2021-12-16 | Buy |
| Ambeed | A133052 | 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+% | 2mg | $31 | 2021-12-16 | Buy |
| Ambeed | A133052 | 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+% | 5mg | $54 | 2021-12-16 | Buy |
| Ambeed | A133052 | 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+% | 10mg | $79 | 2021-12-16 | Buy |
| Ambeed | A133052 | 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+% | 25mg | $95 | 2021-12-16 | Buy |
| Ambeed | A133052 | 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+% | 50mg | $115 | 2021-12-16 | Buy |
| Ambeed | A133052 | 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 98+% | 250mg | $206 | 2021-12-16 | Buy |
| ApexBio Technology | A3011 | CHIR-99021(CT99021) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A3011 | CHIR-99021(CT99021) | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A3011 | CHIR-99021(CT99021) | 10mg | $105 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0014 | CHIR 99021 | 2mg | $124 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0014 | CHIR 99021 | 5mg | $211 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0014 | CHIR 99021 | 10mg | $305 | 2021-12-16 | Buy |
| Arctom | AS445836 | CHIR 99021 ≥98% | 2mg | $31 | 2021-12-16 | Buy |
| Arctom | AS445836 | CHIR 99021 ≥98% | 5mg | $53 | 2021-12-16 | Buy |
| Arctom | AS445836 | CHIR 99021 ≥98% | 10mg | $78 | 2021-12-16 | Buy |
Properties
Boiling point :784.1±70.0 °C(Predicted)
Density :1.48
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :11.92±0.10(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :AQGNHMOJWBZFQQ-UHFFFAOYSA-N
CAS DataBase Reference :252917-06-9
Density :1.48
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :11.92±0.10(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :AQGNHMOJWBZFQQ-UHFFFAOYSA-N
CAS DataBase Reference :252917-06-9
Safety Information
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Description
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a key inhibitory role in both the insulin and Wnt signaling pathways. CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.8 μM) and in isolated type 1 diabetic rat skeletal muscle. A single oral dose (30 mg/kg) of CHIR99021 enhances in vivo glucose metabolism in a rodent model of type 2 diabetes. CHIR99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.Related product price
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![6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile](https://img.chemicalbook.com/ProductImageEN/2018-12/small/a8d9b725-3501-41e9-8ab0-ffa7fdbdccca.jpg){kind=small}