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252917-06-9

中文名稱 6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈
英文名稱 CHIR-99021
CAS 252917-06-9
分子式 C22H18Cl2N8
MDL 編號(hào) MFCD11846251
分子量 465.34
MOL 文件 252917-06-9.mol
更新日期 2024/12/20 09:35:50
252917-06-9 結(jié)構(gòu)式 252917-06-9 結(jié)構(gòu)式

基本信息

中文別名
抑制劑CHIR-99021
6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈
6-[[2-[[4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)-2-嘧啶]氨基]乙基]氨基]-3-吡啶甲腈
英文別名
CT99021
CHIR-99021
GSK-3 Inhibitor XVI
CT 99021(CHIR 99021)
CHIR 99021(CT 99021)
CHIR-99021 (CT99021) HCl
CHIR 911, GSK-3 Inhibitor XVI
CHIR-99021 GSK-3 Inhibitor XVI
6-[2-[4-(2,4-Dichlorophenyl)-5-(4-Methyl-1H-iMidazol-2-yl)pyriMidin-2-ylaMino]ethylaMino]pyridine-3-
6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile
所屬類別
醫(yī)藥中間體:乙基吡啶

物理化學(xué)性質(zhì)

沸點(diǎn)784.1±70.0 °C(Predicted)
密度1.48
儲(chǔ)存條件?20°C
儲(chǔ)存條件-20°C
溶解度DMSO:可溶,2mg/mL,澄清(加熱)
酸度系數(shù)(pKa)11.92±0.10(Predicted)
形態(tài)粉末
顏色白色至淺棕色
穩(wěn)定性DMSO中的溶液可在-20°下穩(wěn)定儲(chǔ)存3個(gè)月。
InChIKeyAQGNHMOJWBZFQQ-UHFFFAOYSA-N
CAS 數(shù)據(jù)庫(kù)252917-06-9

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H300-H315-H319-H335
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼25-36/37/38
安全說(shuō)明26-36/37/39-45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGIII
WGK Germany3
海關(guān)編碼29335990

常見(jiàn)問(wèn)題列表

產(chǎn)品描述
CHIR99021是一種氨基嘧啶衍生物,其抑制GSK3α和GSK3β的IC50值分別為10和6.7 nM。
生物活性
CHIR-99021 (CT99021)是一種GSK-3α和GSK-3β抑制劑, IC50分別為10 nM and 6.7 nM。CHIR99201對(duì)CDKs沒(méi)有交叉反應(yīng)性,對(duì)GSK-3β的選擇性是對(duì)CDKs選擇性的350倍。CHIR-99021 可作為Wnt/β-catenin的激活劑并誘導(dǎo)自噬。
靶點(diǎn)
TargetValue
GSK-3β
(Cell-free assay)
6.7 nM
GSK-3α
(Cell-free assay)
10 nM
體外研究

CHIR-99021 inhibits human GSK-3β with K i values of 9.8 nM. CHIR-99021 is a small organic molecule that inhibits GSK3α and GSK3β by competing for their ATP-binding sites.In vitro kinase assays reveal that CHIR-99021 specifically inhibits GSK3β (IC 50 =~5 nM) and GSK3α (IC 50 =~10 nM), with little effect on other kinases. In the presence of CHIR-99021 the viability of the ES-D3 cells is reduced by 24.7% at 2.5 μM, 56.3% at 5 μM, 61.9% at 7.5 μM and 69.2% at 10 μM CHIR-99021 with an IC 50 of 4.9 μM.

體內(nèi)研究

In ZDF rats, a single oral dose of CHIR-99021 (16 mg/kg or 48 mg/kg) rapidly lowers plasma glucose, with a maximal reduction of nearly 150 mg/dl 3-4 h after administration. CHIR99021 (2 mg/kg) given once, 4 h before irradiation, significantly improves survival after 14.5 Gy abdominal irradiation (ABI). CHIR99021 treatment significantly blocks crypt apoptosis and accumulation of p-H2AX + cells, and improves crypt regeneration and villus height. CHIR99021 treatment increases Lgr5 + cell survival by blocking apoptosis, and effectively prevents the reduction of Olfm4, Lgr5 and CD44 as early as 4 h.

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