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      ????????XNUMX???
      ????????XNUMX??? ??? ???
      ?? ??:
      6106-07-6
      ???:
      ????????XNUMX???
      ???(??):
      ????????XNUMX???
      ???:
      Sodium levothyroxine pentahydrate
      ???(??):
      lt,pentahydrate,;L-THYROXINE SODIUM PENTAHYDRATE;SODIUM L-THYROXINE PENTAHYDRATE;SODIUM LEVOTHYROXINE PENTAHYDRATE;L-THYROXINE SODIUM SALT PENTAHYDRATE;Sodium levothyroxine pentahydrate 98%;L-Thyroxine pentahydrate sodium salt;L-Thyroxine sodiuM salt pentahydD23-Rate;L-THYROXINE, SODIUM SALT PENTAHYDRATE, 9 9%;L-Thyroxinesodiumsaltpentahydratecrystalline
      CBNumber:
      CB2123792
      ???:
      C15H20I4NNaO9
      ??? ??:
      888.93
      MOL ??:
      6106-07-6.mol

      ????????XNUMX??? ??

      ???
      207-210 (dec.)(lit.)
      ??
      [α]D20 +15~+19°
      ??
      2.381
      ?? ??
      2-8°C
      ???
      ?? ?? ??: 0.1mg/mL
      ??? ??
      ??
      ??
      ???? ???, ?????
      ???? ??
      synthetic (organic)
      BRN
      5721845
      CAS ??????
      6106-07-6(CAS DataBase Reference)
      ??
      • ?? ? ?? ??
      • ?? ? ???? ?? (GHS)
      ??? ?? Xn
      ?? ???? ?? 40
      ????? 22-24/25-36
      WGK ?? 3
      RTECS ?? YP2833760
      F ?????? 3-8-10
      ????(GHS): GHS hazard pictograms
      ?? ?: Danger
      ??·?? ??:
      ?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
      H372 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ?? ???? ?? - ?? ?? ?? 1 ?? GHS hazard pictograms P260, P264, P270, P314, P501
      ??????:
      P260 ??·?·??·???·??·...·????? ???? ???.
      P264 ?? ??? ?? ??? ????.
      P264 ?? ??? ?? ??? ????.
      P270 ? ??? ??? ??? ???, ???? ???? ???.
      P314 ???? ??? ???? ??·??? ????.
      P501 ...? ??? / ??? ?? ???.

      ????????XNUMX??? C??? ??, ??, ??

      ???

      A reproductive hazard.

      Biochem/physiol Actions

      L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

      Purification Methods

      Crystallise the sodium salt from absolute EtOH and dry it for 8hours at 30o/1mm. [Canepa Acta Cryst 4 283 1951, Beilstein 14 II 378, 14 III 1566, 14 IV 2374.]

      ????????XNUMX??? ?? ?? ? ???

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