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6106-07-6

中文名稱 左旋甲狀腺素鈉五水合物
英文名稱 Sodium levothyroxine pentahydrate
CAS 6106-07-6
分子式 C15H20I4NNaO9
MDL 編號 MFCD00149110
分子量 888.93
MOL 文件 6106-07-6.mol
更新日期 2024/09/02 17:18:51
6106-07-6 結(jié)構(gòu)式 6106-07-6 結(jié)構(gòu)式

基本信息

中文別名
3',3,5',5-四碘甲腺原氨酸鈉鹽五水合物
O-(4-羥基-3,5-二碘苯基)-3,5-二碘-L-酪氨酸單鈉鹽五水合物
左旋甲狀腺素鈉五水合物
英文別名
3,3',5,5'-TETRAIODO-L-THYRONINE SODIUM SALT PENTAHYDRATE
3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE PENTAHYDRATE
3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE SODIUM SALT PENTAHYDRATE
L-THYROXINE SODIUM PENTAHYDRATE
L-THYROXINE SODIUM SALT PENTAHYDRATE
(S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT PENTAHYDRATE
SODIUM LEVOTHYROXINE PENTAHYDRATE
SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE PENTAHYDRATE
3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-alaninmonosodiumsa
lt,pentahydrate,
l-tyrosine,o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-,sodiumsalt,pentahydra
o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosinesodiumsaltpentahydrate
L-thyroxine sodium pentahydrate*gamma-irradiated
sodium L-4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzylalaninate pentahydrate
L-THYROXINE, SODIUM SALT PENTAHYDRATE, 9 9%
L-THYROXINE SODIUM PENTAHYDRATE*GAMMA-IR RADIATED CE
L-Thyroxinesodiumsaltpentahydratecrystalline
3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-l-alanine sodium salt
O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine monosodium salt pentahydrate
SODIUM L-THYROXINE PENTAHYDRATE
所屬類別
醫(yī)藥中間體:原料藥中間體

物理化學(xué)性質(zhì)

熔點207-210 (dec.)(lit.)
比旋光度[α]D20 +15~+19°
密度2.381
儲存條件2-8°C
溶解度cell culture medium: 0.1 mg/mL
形態(tài)powder
形態(tài)粉末
顏色白色到黃色到橙色
BRN5721845
CAS 數(shù)據(jù)庫6106-07-6(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS08
警示詞危險
危險性描述H372
危險品標(biāo)志Xn
危險類別碼40
安全說明S22-S24/25
WGK Germany3
RTECS號YP2833760

知名試劑公司產(chǎn)品信息

左旋甲狀腺素鈉五水合物價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-18341A左旋甲狀腺素鈉五水合物
L-Thyroxine sodium salt pentahydrate
6106-07-6500mg650元
2024/11/08HY-18341A左旋甲狀腺素鈉五水合物
L-Thyroxine sodium salt pentahydrate
6106-07-610mM * 1mLin DMSO715元
2024/11/08HY-18341A左旋甲狀腺素鈉五水合物
L-Thyroxine sodium salt pentahydrate
6106-07-61g850元

常見問題列表

生物活性
L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) 是一種合成的甲狀腺激素,用于甲狀腺功能減退癥的研究。DIO 酶將 L-Thyroxine (T4) 轉(zhuǎn)化成具有生物活性的三碘甲狀腺氨酸 (T3)。
靶點

Thyroid Hormone Receptor

體內(nèi)研究

Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03).

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