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ChemicalBook >> CAS DataBase List >>Sodium levothyroxine pentahydrate

Sodium levothyroxine pentahydrate

CAS No.
6106-07-6
Chemical Name:
Sodium levothyroxine pentahydrate
Synonyms
lt,pentahydrate,;L-THYROXINE SODIUM PENTAHYDRATE;SODIUM L-THYROXINE PENTAHYDRATE;SODIUM LEVOTHYROXINE PENTAHYDRATE;L-THYROXINE SODIUM SALT PENTAHYDRATE;Sodium levothyroxine pentahydrate 98%;L-Thyroxine pentahydrate sodium salt;L-Thyroxine sodiuM salt pentahydD23-Rate;L-THYROXINE, SODIUM SALT PENTAHYDRATE, 9 9%;L-Thyroxinesodiumsaltpentahydratecrystalline
CBNumber:
CB2123792
Molecular Formula:
C15H20I4NNaO9
Molecular Weight:
888.93
MDL Number:
MFCD00149110
MOL File:
6106-07-6.mol
Last updated:2025-04-18 09:51:46

Sodium levothyroxine pentahydrate Properties

Melting point 207-210 (dec.)(lit.)
alpha [α]D20 +15～+19°
Density 2.381
storage temp. 2-8°C
solubility cell culture medium: 0.1 mg/mL
form powder
color White to Yellow to Orange
biological source synthetic (organic)
BRN 5721845
CAS DataBase Reference 6106-07-6(CAS DataBase Reference)
FDA UNII 9J765S329G
UNSPSC Code 51111800
NACRES NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H372
Precautionary statements  P260-P264-P270-P314-P501
Hazard Codes  Xn
Risk Statements  40
Safety Statements  22-24/25-36
WGK Germany  3
RTECS  YP2833760
F  3-8-10

Sodium levothyroxine pentahydrate price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T0397 L-Thyroxine sodium salt pentahydrate γ-irradiated, powder, BioXtra, suitable for cell culture 6106-07-6 1MG $62 2024-03-01 Buy
Sigma-Aldrich T2501 L-Thyroxine sodium salt pentahydrate ≥98% (HPLC), powder 6106-07-6 1G $174 2023-06-20 Buy
Sigma-Aldrich T2501 L-Thyroxine sodium salt pentahydrate ≥98% (HPLC), powder 6106-07-6 5G $695 2023-06-20 Buy
TCI Chemical T0245 L-Thyroxine Sodium Salt Pentahydrate 6106-07-6 100MG $19 2024-03-01 Buy
TCI Chemical T0245 L-Thyroxine Sodium Salt Pentahydrate 6106-07-6 1G $53 2024-03-01 Buy
Product number Packaging Price Buy
T0397 1MG $62 Buy
T2501 1G $174 Buy
T2501 5G $695 Buy
T0245 100MG $19 Buy
T0245 1G $53 Buy

Sodium levothyroxine pentahydrate Chemical Properties,Uses,Production

Uses

L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].

Hazard

A reproductive hazard.

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

in vivo

Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion[1]. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03)[2].

IC 50

Human Endogenous Metabolite

Purification Methods

Crystallise the sodium salt from absolute EtOH and dry it for 8hours at 30o/1mm. [Canepa Acta Cryst 4 283 1951, Beilstein 14 II 378, 14 III 1566, 14 IV 2374.]

References

[1] Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323. DOI:10.1507/endocrj.EJ17-0162
[2] Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149. DOI:10.1016/j.jcte.2014.09.005

Sodium levothyroxine pentahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Sodium levothyroxine pentahydrate Suppliers

Global( 111)Suppliers
Supplier Tel Email Country ProdList Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368 sales@sjar-tech.com China 485 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Henan Alfa Chemical Co., Ltd 		+8615838112936 alfa10@alfachem.cn China 13194 58
PT CHEM GROUP LIMITED 		+86-85511178; +86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49984 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58

View Lastest Price from Sodium levothyroxine pentahydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sodium Levothyroxine Pentahydrate pictures 2025-01-13 Sodium Levothyroxine Pentahydrate
6106-07-6
 US $0.00 / g 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Sodium levothyroxine pentahydrate pictures 2020-01-05 Sodium levothyroxine pentahydrate
6106-07-6
 US $1.00 / KG 1KG 95-99% 1ton Career Henan Chemical Co
3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE SODIUM SALT PENTAHYDRATE 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE PENTAHYDRATE 3,3',5,5'-TETRAIODO-L-THYRONINE SODIUM SALT PENTAHYDRATE (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT PENTAHYDRATE SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE PENTAHYDRATE SODIUM LEVOTHYROXINE PENTAHYDRATE 3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-alaninmonosodiumsa lt,pentahydrate, L-THYROXINE SODIUM PENTAHYDRATE L-THYROXINE SODIUM SALT PENTAHYDRATE l-tyrosine,o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-,sodiumsalt,pentahydra o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosinesodiumsaltpentahydrate L-thyroxine sodium pentahydrate*gamma-irradiated sodium L-4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzylalaninate pentahydrate L-THYROXINE, SODIUM SALT PENTAHYDRATE, 9 9% L-THYROXINE SODIUM PENTAHYDRATE*GAMMA-IR RADIATED CE L-Thyroxinesodiumsaltpentahydratecrystalline 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-l-alanine sodium salt O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine monosodium salt pentahydrate L-Thyroxine pentahydrate sodium salt Sodium levothyroxine, T4, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt SODIUM L-THYROXINE PENTAHYDRATE 0-( 4-HYDROXY-3,5-DIIDOPHENYL)-N-ACEYTL)-3,5-DIIODO-L-TYROSINE ETHYL ESTER sodiuM (S)-2-aMino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate pentahydrate L-Thyroxine sodiuM salt pentahydD23-Rate sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)- 3,5-diiodophenyl]propanoate pentahydrate L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine pentahydrate) L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt, hydrate (1:1:5) L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine) Sodium levothyroxine pentahydrate 98% L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine), thyroid prohormone (T4) L-Thyroxine sodium salt pentahydrate 6106-07-6 HOC6H2I2OC6H2I2CH2CHNH2COONa5H2O C15H10O4NI4Nax5H2O C15H10I4NO4Na5H2O Cytokines, Growth Factors and Hormones Other Protein/Peptide Hormones Hormones Thyroxine (T4) Cell Signaling and Neuroscience Cell Biology BioChemical Hormones