L-(-)-???
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L-(-)-??? ??
- ???
- >300 °C (dec.) (lit.)
- ?? ?
- 314.29°C (rough estimate)
- ??
- -11.65 º (c=5,DIL HCL/H2O 50/50)
- ??
- 1.34
- ?? ??
- 300kg/m3
- ???
- -12 ° (C=5, 1mol/L HCl)
- FEMA
- 3736 | L-TYROSINE
- ???
- 176 °C
- ?? ??
- Store below +30°C.
- ???
- 1 M HCl: 25 mg/mL
- ??? ??
- ??
- ?? ?? (pKa)
- 2.2(at 25℃)
- ??
- ???? ?? ??
- ??????(pH)
- 6.5 (0.1g/l, H2O)
- ??
- ?? ??
- ?? ??
- ?? ??
- ???? ??
- rabbit
- optical activity
- [α]20/D 11.5±1.0°, c = 4% in 1 M HCl
- ???
- 0.45g/L(25℃)
- JECFA Number
- 1434
- Merck
- 14,9839
- BRN
- 392441
- ???
- ????. ?? ???, ?? ???? ???? ????.
- InChIKey
- OUYCCCASQSFEME-QMMMGPOBSA-N
- LogP
- 0.38
- CAS ??????
- 60-18-4(CAS DataBase Reference)
- NIST
- Tyrosine(60-18-4)
- Absorption
- cut-off at 310nm in 1 M HCl at 0.5M
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-40 | ||
| ????? | 26-36-37/39-22 | ||
| WGK ?? | 3 | ||
| RTECS ?? | YP2275600 | ||
| TSCA | Yes | ||
| HS ?? | 29225000 | ||
| ?? ?? ??? | 60-18-4(Hazardous Substances Data) | ||
| ?? | LD50 orally in Rabbit: > 5110 mg/kg | ||
| ???? ?? | KE-01396 |
L-(-)-??? C??? ??, ??, ??
??
???? ??? ?? ?? ? ?? ?? ??? ?????? ??? ??? ?? ??????. ?? ?? ? ??? ???? ??? ???? ???? ??? ??????. ??? ??? ?????? ??? ??? ?????. ??? ??? ??? ??? ??? ??? ?????, ?? ?? ??? ??? ?????, ?? ?? ??? ??? ????.??
L-tyrosine? ?? ???? ?? ???? ?????? ??????. ??? ????, ? ?? ??? ???? ???? ? ??? ??? ?? ??? ???? ?? ??? ???? ??????.????
? (1) ?? : ? ?? 1g? 1N ?? 20mL? ?? ?? ???? ?? ????? ??.
??(2) ?? : ? ??? ?????? pH? 5.0～6.5??? ??.
??(3) ???? : ? ?? ? 5g? ??? ?? 1N ??? ?? 100mL? ?? ? ?? ???? ???? ?? ???? ??? ?, 
＝-10.5～-12.5°??? ??.
??(4) ??? : ? ?? 0.07g? ??? ??????? ?? ??? ?, ? ?? 0.01N ?? 0.2mL? ???? ? ????? ??.
??(5) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.
??(6) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 5.0ppm ????? ??.
????
? (1) ? ??? ????? 5mL? ??????(1→50) 1mL? ??? ?? ??? 3?? ??? ? ???? ????.
??(2) ? ??? ????? 5mL? ??????? 1mL? ??? ??? ?, ?? ???? ????.
???
? ? ?? ? 0.3g? ??? ?? ??? 3mL? ??? ???(?????) 50mL? ??? 0.1N ???????? ????(??? : ?????????????? 1mL). ???? ?? ??? ??? ?? ???? ??? ???. ?? ?? ???? ???? ??.
0.1N ?????? 1mL ＝ 18.119mg C9H11NO3
?????
? ? ??? ?????? 0.1% ????? ??.
??? ??
L-Tyrosine is odorless and has a bland taste. L-Tyrosine is a nonessential amino acid, as it is synthesized in the human body from phenylalanine. It is a precursor to epinephrine, norepinephrine and dopamine, three important neurotransmitters.??
Reported found in white bread, macaroni, egg noodles, corn flakes, corn grits, oatmeal, wheat bran, wheat flakes, shredded wheat, barley brown rice, rye flour, whole grain wheat flour, buttermilk, blue cheese, cheddar cheese, cottage cheese, cream cheese, parmesan cheese, bacon, cured ham, frankfurters, pork sausage, canned red kidney beans, canned sweet corn, canned peas, canned lima beans, canned potatoes, almonds, cashews, peanuts, dates, beef, lamb, veal, chicken and turkey.??
L-Tyrosine is one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.??
ChEBI: An optically active form of tyrosine having L-configuration.Safety Profile
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.Purification Methods
Likely impurities are L-cysteine and the ammonium salt. L-Tyrosine is dissolved in dilute ammonia, then crystallised by adding dilute acetic acid to pH 5. Also, crystallise it from H2O or EtOH/H2O, and dry it at room temperature in a vacuum over P2O5. It sublimes at 235-240o/0.03mm with 99.2% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Albert Biochem J 50 690 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2348-2366 1961, Beilstein 14 IV 2264.]L-(-)-??? ?? ?? ? ???
???
Industrial hydrochloric acid
?????????
Boc-D-Tyr-OH
Α-protein
Hydrolyzate
??
Syrup, NF
???
??????????????
?? ??
L-(-)-??? ?? ??
???( 1013)?? ??
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