Amlodipine
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- CAS-Nr.
- 88150-42-9
- Englisch Name:
- Amlodipine
- Synonyma:
- AMLODIPINE BASE;besylate;Amlodipin;AmL;phytoxanthin;AMlodipine-d4 Maleate;Amlodipine base (crystalline);3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate;Isti;Pelmec
- CBNumber:
- CB9366505
- Summenformel:
- C20H25ClN2O5
- Molgewicht:
- 408.88
- MOL-Datei:
- 88150-42-9.mol
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Amlodipine Eigenschaften
- Schmelzpunkt:
- 178-179°C
- Siedepunkt:
- 527.2±50.0 °C(Predicted)
- Dichte
- 1.227±0.06 g/cm3(Predicted)
- RTECS-Nr.
- US7968329
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
- pka
- pKa 8.6 (Uncertain)
- Aggregatzustand
- Almost white crystal powder
- Farbe
- White
- Wasserl?slichkeit
- 75.3 mg/L
- BCS Class
- 1
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
- CAS Datenbank
- 88150-42-9(CAS DataBase Reference)
- EPA chemische Informationen
- 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
   
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
| H373 |
Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P405 |
Unter Verschluss aufbewahren. |
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Amlodipine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC
50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition
in vitro and
in vivo. Formulations containing amlodipine have been used in the treatment of hypertension.
Chemische Eigenschaften
Yellow Solid
Verwenden
A deuterated dihydropyridine calcium channel blocker.;Application of Labeled APIs: Labeled Amlodipine, intended for use as an internal standard for the quantification of Amlodipine by GC- or LC-mass spectrometry.
Definition
ChEBI: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Allgemeine Beschreibung
Amlodipine, 2-[, for the treatment of hypertension. Amlodipineis also marketed as a combination therapy with atorvastatinunder the tradename Norvasc for the management of highcholesterol and high blood pressure.
Hazard
Human systemic effects.
Sicherheitsprofil
Human systemic effects. Whenheated to decomposition it emits toxic vapors of NOx andCl
-.
Amlodipine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Amlodipine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 564)Lieferanten
88150-42-9()Verwandte Suche:
- AMLODIPINE MM(CRM STANDARD)
- Amlodipine&Int
- AmlodipineBesylate/Maleate
- 3,5-Pyridinedicarboxylic acid, 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
- ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- Pelmec
- Racemic Amlodipine
- 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor 3-ethyl 5-methyl ester
- Amlodipine Besilate Imp.(EP)
- 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-ethyl O5-methyl ester
- Amlodipine besilate (JAN)
- Amlodipine besylate (USAN)
- Isti
- O3-ethyl O5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- Amlodipine, >=99%
- (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- 4-(2-chloro-phenyl-2(3-(1,3-dioxo-l,3-dihydro-isoindol-2yl-prpionyl)6-methyl-pyridin3, 5-dicarboxylic acid-ethyl-ethyl ester 5-methyl ester (p-2) of RS amlodipine besylate
- AMlodipine besylate, >95%
- Amlodipine Besylate IMP
- Amlodipine (base and/or unspecified salts)
- AMLODIPINE (BASE & SALTS)
- Amlodipine ( Amlodipine Benzenesulfonate)
- 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1，4-dihydro-3，5-pyridinedicarboxylic acid 5-methyl 3-ethyl ester
- UK-48340
- UK-48340-11
- 2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl=5-methyl ester
- 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
- AMLODIPINE
- methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- LOTREL
- 3-ethyl5-methylester
- 2-Methyl-4-(2-chlorophenyl)-6-[[(2-aminoethyl)oxy]methyl]-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-ethyl ester
- 4-(2-Chlorophenyl)-2-methyl-6-(2-aminoethoxymethyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-ethyl ester
- 4-(2-Chlorophenyl)-6-methyl-2-(2-aminoethoxymethyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester
- 3-ethyl 5-Methyl (4S)-2-[(2-aMinoethoxy)Methyl]-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate
- AMlodipine(Norvasc)
- AMlodiping Besylate
- (R,S)-AMlodipine
- AMlopres
- Intervask
- 2-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
- AMLODIPINE (RS)-3-ETHYL-5-METHYL-2[(2-AMINOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
- 3,5-pyridinedicarboxylicacid,1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor
- (R)-3-ethyl 5-methyl 2
- [2H4]-Amlodipine besylate
- odipine besyL
- Amlodipine Solution in Methanol, 100μg/mL
- Amlodipine USP/EP/BP
- Amlodipine (UK-48340
- amlodipineQ: What is
amlodipine Q: What is the CAS Number of
amlodipine Q: What is the storage condition of
amlodipine Q: What are the applications of
amlodipine
- AMLODIPINE BASE
- Amlodipin
- besylate
- 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate
- AMlodipine-d4 Maleate
- Amlodipine base (crystalline)
- phytoxanthin
- AmL
