Baclofen
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Baclofen Eigenschaften
- Schmelzpunkt:
- 208-210°C
- Siedepunkt:
- 364.3±32.0 °C(Predicted)
- Dichte
- 1.2069 (rough estimate)
- Brechungsindex
- 1.5500 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- 1 M HCl: 50 mg/mL
- Aggregatzustand
- solid
- pka
- pKa 3.87±0.1(H2O) (Uncertain)
- Farbe
- white to very faintly yellow
- Wasserl?slichkeit
- Soluble in dilute NaOH or dilute HCl. Soluble in water at approximately 4mg/ml at pH 7.6
- Merck
- 14,937
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
- InChIKey
- KPYSYYIEGFHWSV-UHFFFAOYSA-N
- SMILES
- C1(C=CC(Cl)=CC=1)C(CN)CC(=O)O
- CAS Datenbank
- 1134-47-0(CAS DataBase Reference)
- NIST chemische Informationen
- Baclofen(1134-47-0)
- EPA chemische Informationen
- .beta.-(Aminomethyl)-4-chlorobenzenepropanoic acid (1134-47-0)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T,Xn | ||
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R-S?tze: | 61-25-36/37/38-42/43-20/21/22 | ||
S-S?tze: | 53-22-36/37/39-45-52-36-26 | ||
RIDADR | UN 2811 6.1/PG 3 | ||
WGK Germany | 3 | ||
RTECS-Nr. | MW5084200 | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 2922492050 | ||
Toxizit?t | LD50 in male mice, rats (mg/kg): 45, 78 i.v.; 103, 115 s.c.; 200, 145 orally (Tadokoro) |
Bildanzeige (GHS) |
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Sicherheit |
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Baclofen Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R61:Kann das Kind im Mutterleib sch?digen.R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S52:Nicht gro?fl?chig für Wohn- und Aufenthaltsr?ume zu verwenden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Off-White SolidVerwenden
Baclofen may be used as a pharmaceutical secondary reference standard for the determination of the analyte in plasma samples by liquid chromatography tandem mass spectrometry and tablet formulations by UV spectroscopy, respectively.Definition
ChEBI: A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.Biologische Funktion
Baclofen (Lioresal) is the parachlorophenol analogue of the naturally occurring neurotransmitter γ-aminobutyric acid (GABA).Allgemeine Beschreibung
Odorless or practically odorless white to off-white crystalline powder.Air & Water Reaktionen
Insoluble in water.Reaktivit?t anzeigen
Baclofen is an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.Brandgefahr
Flash point data for Baclofen are not available. Baclofen is probably combustible.Biologische Aktivit?t
Selective GABA B receptor agonist. Skeletal muscle relaxant.Mechanism of action
Baclofen appears to affect the neuromuscular axis by acting directly on sensory afferents, γ-motor neurons, and collateral neurons in the spinal cord to inhibit both monosynaptic and polysynaptic reflexes. The principal effect is to reduce the release of excitatory neurotransmitters by activation of presynaptic GABAB receptors. This seems to involve a G protein and second-messenger link that either increases K+ conductance or decreases Ca++ conductance.Clinical Use
Baclofen is an agent of choice for treating spinal spasticity and spasticity associated with multiple sclerosis. It is not useful for treating spasticity of supraspinal origin. Doses should be increased gradually to a maximum of 100 to 150 mg per day, divided into four doses.Nebenwirkungen
Side effects are not a major problem, and they can be minimized by graduated dosage increases.They include lassitude, slight nausea, and mental disturbances (in including confusion, euphoria, and depression). The drowsiness is less pronounced than that produced by diazepam—an important therapeutic advantage. Hypotension has been noted, particularly following overdose. Elderly patients and patients with multiple sclerosis may require lower doses and may display increased sensitivity to the central side effects. Baclofen may increase the frequency of seizures in epileptics.Sicherheitsprofil
Poison by ingestion,subcutaneous and intravenous routes. Human systemiceffects by ingestion: blood pressure lowering, coma,muscle weakness, pulse rate decrease, respiratorydepression. When heated to decomposition it emits toxicfumes of Cl-Stoffwechsel
Baclofen is rapidly and effectively absorbed after oral administration. It is lipophilic and able to penetrate the blood-brain barrier.Approximately 35% of the drug is excreted unchanged in the urine and feces.Baclofen Upstream-Materialien And Downstream Produkte
Upstream-Materialien
4-Chlorbenzaldehyd
Acetoxyessigsure
Ethyl-2-acetylacetoacetat
Chlorbenzol
Glutarsureanhydrid
Glutarsure
Natriumhydroxid
Downstream Produkte
Baclofen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 571)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
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Joyochem Co.,Ltd | +86-0531-82687558 +8613290333633 |
sales@joyochem.com | China | 31 | 58 |
Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 |
mack@tongyon.com | China | 2994 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 |
allison@yan-xi.com | China | 5854 | 58 |
Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 |
market02@senwayer.com | China | 923 | 58 |
Zibo Wei Bin Import & Export Trade Co. Ltd. | +86-0533-2091136 +8613864437655 |
ziboweibinmaoyi@163.com | China | 100 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3883 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5868 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 |
mina@chuanghaibio.com | China | 18137 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 |
sales1@hbganmiao.com | China | 227 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
1134-47-0(Baclofen)Verwandte Suche:
Chlortriphenylmethan
tert-Butylchlordiphenylsilan
CHLOROMETHYL BUTYRATE
Chlorphenylsilan
4-Phenylbuttersure
4-Aminobuttersure
Baclofen
- 4-Amino-3-(p-chlorophenyl)butyric acid
- Benzenepropanoic acid, β-(aminomethyl)-4-chloro-
- CIBA Ba 34647
- DL-4-Amino-3-p-chlorophenylbutanoic acid
- DL-Baclofen
- Hydrocinnamic acid, β-(aminomethyl)-p-chloro- (7CI, 8CI)
- β-(4-Chlorophenyl)-γ-aminobutyric acid
- β-p-Chlorophenyl-GABA
- Baclofen(R)
- (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
- g-Amino-b-(p-chlorophenyl)butyric acid
- Baclofen13C2
- -(4-Chlorophenyl)-GABA
- -(Aminomethyl)-4-chloro-benzenepropanoic Acid
- (±)-Baclofen,(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
- Baclofen (350 mg)
- Baclofen (500 mg)
- β-(Aminomethyl)-4-chlorohydrocinnamic acid
- Clofen
- Lioresa
- Benzenepropanoic acid, .beta.-(aminomethyl)-4-chloro-
- BACLOFEN,USP
- Hydrocinnamic acid, b-(aminomethyl)-p-chloro.
- beta-(aminomethyl)-p-chloro-hydrocinnamicaci
- beta-(aminomethyl)-p-chlorohydrocinnamicacid
- beta-(p-chlorophenyl)-gamma-aminobutyricacid
- c34647ba
- ciba34,647-ba
- gamma-amino-beta-(p-chlorophenyl)butyricacid
- 4-AMino-3-(4-chlorophenyl)butyric Acid, Baclofen
- Baclofen beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
- (RS)-4-AMINO-3-(4-CHLOROPHENYL)BUTANOIC ACID
- (RS)-BACLOFEN
- -(Aminomethyl)-4-chlorobenzenpropanoicacid
- -(p-Chlorophenyl)-aminobutyricacid
- ba34647
- baclon
- beta-(4-chlorophenyl)gaba
- beta-(aminomethyl)-4-chloro-benzenepropanoicaci
- 4-AMINO-3-[4-CHLOROPHENYL]BUTANOIC ACID
- 4-AMINO-3(4-CHLOROPHENYL)BUTYRIC ACID
- (+/-)-BACLOFEN
- BACLOFEN
- AURORA KA-6748
- (+/-)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID
- (+/-)-BETA-(AMINOETHYL)-4-CHLOROBENZENEPROPANOIC ACID
- LIORESAL
- (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
- Atrofen
- beta-(4-chlorophenyl)-gamma-aminobutyric acid
- Beta-(4-Chlorophenyl)-Gaba,Usp
- (3RS)-4-AMINO-3-(P-CHLOROPHENYL)BUTANOIC ACID
- (+/-)-BACLOFEN, PHARMA
- 4-Amino-3-[Chlorophenyl] butanoic acid
- β-[Aminomethyl]-p-chlorohydrocinnamic acid
- (+/-)-Baclofen(USPgrade)
- b-(4-Chlorophenyl)-GABA
- b-(Aminomethyl)-4-chloro-benzenepropanoic Acid