Phenylquecksilberacetat Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
GERUCHLOSES, HYGROSKOPISCHES, WEISSES ODER GELBWEISSES, KRISTALLINES PULVER.
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft m?glich.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Quecksilber- und Quecksilberoxidd?mpfe. Reagiert mit starken Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV: (als Hg) 0,1 mg/m?(als TWA); Hautresorption; (ACGIH 2005).
MAK: (Quecksilberverbindungen, organisch) Hautresorption; Sensibilisierung der Haut; Krebserzeugend Kategorie 3B; (DFG 2006).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation des Aerosols, über die Haut, und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachl?ssigbar; eine gesundheitssch?dliche Partikelkonzentration in der Luft kann jedoch beim Versprühen schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz ver?tzt die Augen, die Haut und die Atemwege. ?tzend beim Verschlucken. M?glich sind Auswirkungen auf die Nieren mit nachfolgendem Nierenversagen. Die Auswirkungen treten u.U. verz?gert ein. (s. Anm.) ?rztliche Beobachtung notwendig.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen. M?glich sind Auswirkungen auf das Nervensystemund die Nieren mit nachfolgender nerv?ser St?rung und Nierensch?den.
LECKAGE
Zündquellen entfernen. Verschüttetes Material in Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. An sicheren Ort bringen. Chemikalienschutzanzug mit umgebungsluftunabh?ngigem Atemschutzger?t.
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R34:Verursacht Ver?tzungen.
R48/24/25:Giftig: Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition durch Berührung mit der Haut und durch Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37:Geeignete Schutzhandschuhe tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Chemische Eigenschaften
Phenylmercuric acetate occurs as a white to creamy white, odorless
or almost odorless, crystalline powder or as small white prisms or
leaflets.
Verwenden
Phenylmercuric acetate is used as catalyst; fungicide; herbicide; algicide; preservative in antibiotic eye drops, eye cosmetics, shampoos, etc.
Vorbereitung Methode
Phenylmercuric acetate is readily formed by heating benzene with
mercuric acetate.
Allgemeine Beschreibung
Small lustrous prisms. Toxic by ingestion, inhalation and skin absorption. May severely irritate skin and eyes. Used as an herbicide and fungicide. as such, is mixed with organic solvent for the purpose of application.
Reaktivit?t anzeigen
PHENYLMERCURIC ACETATE may react with strong oxidizing agents .
Health Hazard
Extremely toxic. The probable oral lethal dose for humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for a 70 kg (150 lb.) person.
Brandgefahr
Fire may produce irritating or poisonous gases. When heated to decomposition, very toxic mercuric fumes may be given off. Phenylmercuric ion is incompatible with halides, with which precipitates are formed.
Pharmazeutische Anwendungen
Phenylmercuric acetate is used as an alternative antimicrobial
preservative to phenylmercuric borate or phenylmercuric nitrate in
a limited range of cosmetics (in concentrations not exceeding
0.007% of mercury calculated as the metal) and pharmaceuticals. It
may be used in preference to phenylmercuric nitrate owing to its
greater solubility.
Phenylmercuric acetate is also used as a spermicide;
Sicherheitsprofil
Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also MERCURY COMPOUNDS. When heated to decomposition it emits toxic fumes of Hg.
Sicherheit(Safety)
Phenylmercuric acetate is mainly used as an antimicrobial
preservative in topical pharmaceutical formulations. A number of
adverse reactions to mercury-containing preservatives have been
reported; see Phenylmercuric Nitrate.
LD
50 (chicken, oral): 60 mg/kg
LD
50 (mouse, IP): 13 mg/kg
LD
50 (mouse, IV): 18 mg/kg
LD
50 (mouse, oral): 13 mg/kg
LD
50 (mouse, SC): 12 mg/kg
LD
50 (rat, oral): 41 mg/kg
m?gliche Exposition
Phenylmercury acetate is used as an antiseptic, fungicide; for fungal and bacterial control; herbicide and control of crabgrass; mildewcide for paints; slimicide in paper mills. It was also used in contraceptive gels and foams.
Environmental Fate
If released into air, soil, or water, phenylmercuric acetate is
unlikely to volatilize and is instead expected to be bound to
particulates based on a low vapor pressure (6 × 10
-6 mm Hg)
and low Henry’s constant (5.66 × 10
-10 atmm3 mol
-1).
Photolysis has the potential to degrade phenylmercuric acetate,
releasing inorganic mercury which can volatilize and enter the
atmosphere from superficial soils or water. If released into soil,
the mobility of parent phenylmercuric acetic acid is expected to
be high based on a Koc of 60. Water releases would result in
quick dispersion since water solubility is high (4370 mg l
-1).
Once in solution, especially with harder water, it will dissociate
into a salt. The cation will adsorb to particulates or humics suspended in the water column or in sediment, with little bioconcentration
in aquatic species.
Lager
As for other phenylmercuric salts; see Phenylmercuric Nitrate.
Phenylmercuric acetate should be stored in a well-closed
container, protected from light, in a cool, dry place.
Versand/Shipping
UN1674 Phenylmercuric acetate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
l?uterung methode
It forms small colourless lustrous prisms from EtOH. Its solubility in H2O is 0.17%, but it is more soluble in EtOH, Me2CO and *C6H6. [Maynard J Am Chem Soc 46 1510 1925, Coleman et al. J Am Chem Soc 59 2703 1937, J Am Pharm Assoc 25 752 1936, Beilstein 16 IV 1720.] See PhHgOH below.
Inkompatibilit?ten
As for other phenylmercuric salts; see Phenylmercuric Nitrate.
Incompatible with: halides; anionic emulsifying agents and
suspending agents; tragacanth; starch; talc; sodium metabisulfite;
sodium thiosulfate; disodium edetate; silicates; aluminum and other
metals; amino acids; ammonia and ammonium salts; sulfur
compounds; rubber; and some plastics.
Phenylmercuric acetate is reported to be incompatible with
cefuroxime and ceftazidime.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. React to produce soluble nitrate form, precipitate as mercuric sulfide. Return to supplier.
Regulatory Status
Included in the FDA Inactive Ingredients Database (ophthalmic
ointments; topical emulsions/creams; vaginal emulsions/creams).
Included in the Canadian List of Acceptable Non-medicinal
Ingredients (ophthalmic, nasal and otic preparations up to
0.004%; there must be no other suitable alternative preservative
available).
Phenylmercuric acetate is no longer permitted to be used as a
pesticide in the USA. Its use in cosmetic products in the USA is
limited to eye area cosmetics at not more than 0.0065% provided
that there is no other suitable available preservative. It is specifically
prohibited in vaginal contraceptive drug products and antimicrobial
diaper rash drug products in the USA. Phenylmercuric
compounds are prohibited from use in cosmetic products in
Canada.
In Europe, use in cosmetic products is limited to eye makeup and
eye makeup remover at concentrations not exceeding 0.007%
mercury alone or in combination with other permitted mercurial
compounds.In France, a maximum concentration of 0.01% is
permitted for use in pharmaceuticals. The use of mercurial
compounds in cosmetics in Japan is limited to concentrated
shampoo or cream at not more than 0.003% Hg and eye makeup
at not more than 0.0065% Hg.
Phenylquecksilberacetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
