1,3-Dihydroxybenzol Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
WEISSE KRISTALLE. VERF?RBEN SICH ROSA BEI KONTAKT MIT LUFT, LICHT ODER BEI KONTAKT MIT EISEN.
PHYSIKALISCHE GEFAHREN
Flie?en, Schütten o.?. kann zu elektrostatischer Aufladung führen.
CHEMISCHE GEFAHREN
Reagiert mit starken Oxidationsmitteln, Ammoniakund Aminoverbindungen unter Feuer- und Explosionsgefahr.
ARBEITSPLATZGRENZWERTE
TLV: 10 ppm (als TWA); 20 ppm (als STEL); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
EG Arbeitsplatz-Richtgrenzwerte: 10 ppm, 45 mg/m? (als TWA); Hautresorption (EU 2006).
MAK: IIb (MAK nicht festgelegt, aber Informationen vorhanden) Sensibilisierung der Haut; (DFG 2006).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt eine gesundheitssch?dliche Kontamination der Luft nicht oder nur sehr langsam ein, viel schneller jedoch beim Versprühen oder Dispergieren.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt die Augen, die Haut und die Atemwege. M?glich sind Auswirkungen auf das Blut mit nachfolgender Meth?moglobinbildung. Die Auswirkungen treten u.U. verz?gert ein. ?rztliche Beobachtung notwendig.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen.(In seltenen F?llen)
LECKAGE
Verschüttetes Material in Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgf?ltig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Pers?nliche Schutzausrüstung: Atemschutzger?t, P2-Filter für sch?dliche Partikel.
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/38:Reizt die Augen und die Haut.
R50:Sehr giftig für Wasserorganismen.
R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Aussehen Eigenschaften
C6H6O2; 1,3-Dihydroxibenzol, 3-Hydroxyphenol, 1,3-Benzodiol. Farbloser Feststoff mit unangenehmem Geruch.
Gefahren für Mensch und Umwelt
Gesundheitsschädlich beim Verschlucken. Reizt die Augen und die Haut.
Resorption führt zu ZNS-Störungen, Schwindel, Kollaps. Methämoglobinbildner. Kann Funktionsstörung der Schilddrüsse bewirken.
Nicht auf Temperaturen oberhalb des Schmelzpunkts erwärmen. Nicht mit Luft und Oxidationsmitteln in Berührung bringen.
LD
50 (oral, Ratte): 301 mg/kg.
Schutzma?nahmen und Verhaltensregeln
Schutzhandschuhe als kurzzeitiger Staubschutz.
Verhalten im Gefahrfall
Substanzkontakt vermeiden.
Trocken aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Kohlendioxid, Wasser, Schaum, Pulver.
Brennbar. Im Brandfall können gefährliche Brandgase freigesetzt werden. Gefahr der Staubexplosion.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 15 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Viel Wasser trinken lassen. Erbrechen auslösen. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung sofort entfernen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
Gelöst in z.B Aceton als halogenfreie, organische Lösemittelabfälle.
Chemische Eigenschaften
Resorcinol is a white crystalline solid with a
characteristic odor and a sweetish taste. Turns pink on expo-
sure to air or light, or contact with iron.
Occurrence
Reported found in roasted barley, cane molasses, beer, red wine, white wine, special wine and coffee.
Verwenden
In very mild solutions, resorcinol is used as an anti-septic and soothing preparation for itchy skin. In slightly higher concentrations, resorcinol removes the top layer of the stratum corneum and is used particularly in cases of acne. In still higher concentrations, it can act as an aggressive surface skin exfoliant. Resorcinol can also be used as a preservative. While it is a beneficial skin care ingredient when used in low concentrations, it causes irritation in higher concentrations with a strong burning sensation and a reddening of the skin. used in high concentrations as a peel, resorcinol may cause a variety of problems, including swelling. It is is obtained from various resins.
Definition
ChEBI: Resorcinol is a benzenediol that is benzene dihydroxylated at positions 1 and 3. It has a role as an erythropoietin inhibitor and a sensitiser. It is a benzenediol, a member of resorcinols and a phenolic donor.
Indications
Resorcinol (resorcin), a phenol derivative, is less keratolytic than salicylic acid. This
drug is an irritant and sensitizer and reported to be both bactericidal and fungicidal.
Solutions containing 1% to 2% have been used in preparations for seborrhea, acne,
and psoriasis.
Allgemeine Beschreibung
Very white crystalline solid that becomes pink on exposure to light if not completely pure. Burns although ignition is difficult. Density approximately 1.28 g / cm3. Irritating to skin and eyes. Toxic by skin absorption. Used to make plastics and pharmaceuticals.
Air & Water Reaktionen
Hygroscopic. Soluble in water.
Reaktivit?t anzeigen
Resorcine is a weak organic acid. Incompatible with acetanilide, albumin, alkalis, antipyrine, camphor, iron salts, menthol, spirit nitrous ether, and urethane. Can react with oxidizing materials . Has a potentially explosive reaction with concentrated nitric acid [Lewis]. Turns pink on contact with iron.
Hazard
Irritant to skin and eyes. Questionable car-
cinogen.
Health Hazard
The acute oral toxicity of resorcinol is moderate in most test animals. It is less toxic than phenol or catechol. Ingestion or skin absorption can cause methemoglobinemia, cyanosis, and convulsions. Vapors or dusts are irritant to mucous membranes. Contact with the skin or eyes can cause strong irritation. An amount of 100 mg caused severe irritation in rabbit eyes.
LD50 value, oral (rats): 301 mg/kg (NIOSH 1986).
Brandgefahr
Behavior in Fire: Containers may explode.
Kontakt-Allergie
Resorcinol is used in hairdressing as a modifier (or a coupler) of the PPD group of dyes. It is the least frequent sensitizer in hairdressers. It is also used in resins, in skin treatment mixtures, and for tanning. Severe cases of dermatitis due to resorcinol contained in wart preparations have been reported.
Sicherheitsprofil
Human poison by ingestion. Experimental poison by ingestion, intraperitoneal, parenteral, and subcutaneous routes. Moderately toxic experimentally by skin contact and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. A skin and severe eye irritant. It can cause systemic poisoning by acting as both a blood and nerve poison. In a suitable solvent, this material can readily be absorbed through human skin and can cause local hyperemia, itching, dermatitis, edema, and corrosion associated with enlargement of regonal lymph glands as well as serious systemic disorders such as restlessness, methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death. These same symptoms can be induced by ingestion of the material. For poisoning, treat symptomatically. Get medical advice. Used as a topical antiseptic and keratolytic agent. Combustible when exposed to heat or flame; can react with oxidming materials. To fight fEe, use water, CO2, dry chemical. Potentially explosive reaction with concentrated nitric acid. Incompatible with acetadde, alkalies, ferric salts, spirit nitrous ether, urethan. When heated to decomposition it emits acrid smoke and irritating fumes
m?gliche Exposition
Resorcinol is weakly antiseptic;
resorcinol compounds are used in the production of
resorcinol-formaldehyde adhesives; or as an intermediate;
in pharmaceuticals and hair dyes for human use. Major
industrial uses are as adhesives in rubber products and tires,
wood adhesive resins, and as ultraviolet absorbers in
polyolefin plastics. Resorcinol is also a by-product of coal
conversion and is a component of cigarette smoke. Thus,
substantial opportunity exists for human exposure.
Carcinogenicity
Acute Toxicity. The primary signs of intoxication
resemble those induced by phenol, and include initial stimulation
of the CNS, followed by depression, renal glomerular
and tubular degeneration, central hepatic necrosis, myocardial
depression, pruritus, and reddening of the skin. Resorcinol
has been reported to be less toxic than phenol or
pyrocatechol by oral and dermal routes.
Resorcinol is a simple aromatic chemical (1,3-benzenediol)
that has found widespread use, particularly as a coupler
in hair dyes. Clinical experience clearly shows that resorcinol
is a skin sensitizer, although several predictive tests have
been negative. In a local lymph node assay performed in
accordance with OECD Guideline 429, resorcinol was identified
as a skin sensitizer.
Few reports of the toxicity
of resorcinol have been published. Oral ingestion in humans
may cause methemoglobinemia, cyanosis, and convulsions,
whereas dermal exposure has been reported to cause dermatitis,
hyperemia, and pruritus. Industrial inhalation
exposures are rather rare, but could occur in any industry
if the compound is heated beyond 300°F.
Pathology reported for humans
includes anemia, marked siderosis of the spleen and marked
tubular injury in the kidney, fatty changes of the liver,
degenerative changes in the kidney, fatty changes of the
heart muscle, moderate enlargement and pigmentation of
the spleen, and edema and emphysema of the lungs.
Versand/Shipping
UN2876 Resorcinol, Hazard Class: 6.1; Labels:
6.1-Poisonous materials.
l?uterung methode
Crystallise resorcinol from *benzene, toluene or *benzene/diethyl ether. The benzoate has m 117o. [Beilstein 6 IV 2069.]
Inkompatibilit?ten
Reacts with oxidizers, nitric acid; oil,
ferric salts; methanol, acetanilide, albumin, antipyrene,
alkalies, urethane, ammonia, amino compounds.
Hygroscopic; absorbs moisture from the air.
Waste disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations govern-
ing storage, transportation, treatment, and waste disposal.
Dissolve in a combustible solvent and incinerate.
1,3-Dihydroxybenzol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(4-Nitrophenylazo)resorcin
3-CHLORO-4-METHYL-7-HYDROXYCOUNMARIN
adhesive J-20
Benzoximate
2',4'-Dihydroxyhexanophenon
Kalium-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)sulfat
4-OXO-4,5,6,7-TETRAHYDROBENZO[B]FURAN-3-CARBOXYLIC ACID
Ethyl-[[3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetathydrochlorid
Sulisobenzon
2',7'-Dibrom-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-on
3-Ethoxyphenol
3-(Benzyloxy)phenol
Dinatrium-4,4'-[(2,4-dihydroxy-1,3-phenylen)bis(azo)]bisnaphthalin-1-sulfonat
4-Hexylresorcin
Dinatrium-4-[[2,4-diamino-5-[(3-sulfonatophenyl)azo]phenyl]azo]-2-[[2,6-dihydroxy-3-[(4-nitrophenyl)azo]phenyl]azo]benzolsulfonat
1-(1H-indol-4-yloxy)-3-((1-methyl-ethyl)amino)-2-propanol
butadiene-styrene-pyridine copolymer rubber latex
3',6'-Dihydroxy-5(oder 6)-isothiocyanatospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-on
2',4'-Dihydroxypropiophenon
2-BROMORESORCINOL
5-Amino-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoesure
Dinatrium-5,5'-[(2-hydroxytrimethylen)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylat]
7-(Acetyloxy)-4-methyl-2-benzopyron
m-Phenylendibenzoat
Dinatrium-2,2'-[(2,4-dihydroxy-1,3-phenylen)bis(azo-4,1-phenylenimino)]bis(5-nitrobenzolsulfonat)
1-[4-(Benzoyloxy)-2-hydroxyphenyl]-3-phenyl-1,3-propanedione
2,4-Dihydroxybenzoesure
m-Anilinophenol
Dioxybenzon
Merbromin
3,4-DIMETHYLUMBELLIFERONE
8-((Dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-4H-1-benzopyran-4-on
1-(2,4-Bis(benzoyloxy)phenyl)ethanone
1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE
m-(p-Toluidino)phenol
8-ACETYL-7-HYDROXY-4-METHYLCOUMARIN
Fluorescein
4-Chlorresorcin
2,4-DINITROSORESORCINOL
2,7-Naphthalindisulfonsure, 4-Amino-5-hydroxy-, diazotiert, gekoppelt mit diazotiertem 2-Amino-4,6-dinitrophenol, diazotiertem 4-Nitrobenzolamin und Resorcin, Natriumsalze
