Chymotrypsin
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Chymotrypsin Eigenschaften
- Schmelzpunkt:
- 127°C
- Dichte
- 1.37[at 20℃]
- Dampfdruck
- 0Pa at 25℃
- storage temp.
- -20°C
- L?slichkeit
- Reconstitute in 1mM HCl. Soluble at 10mg/ml in 1mM HCl. 2mM calcium chloride serves as a stabilizer. Store aliquoted solutions at -20°C for up to a week.
- Aggregatzustand
- salt-free, lyophilized powder
- Farbe
- white
- Biologische Quelle
- human pancreas
- Wasserl?slichkeit
- 125g/L at 25℃
- Merck
- 13,2282
- Specific Activity
- 2,000-3,500units/g agarose (One ml gel will yield 65-120units)
- LogP
- -1.3 at 20℃
- EPA chemische Informationen
- Chymotrypsin (9004-07-3)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn,B | ||
---|---|---|---|
R-S?tze: | 36/37/38-42/43-42 | ||
S-S?tze: | 26-36-36/37-24-22 | ||
WGK Germany | 3 | ||
RTECS-Nr. | GC3050000 | ||
F | 3-10 | ||
TSCA | Yes | ||
HS Code | 35079090 | ||
Giftige Stoffe Daten | 9004-07-3(Hazardous Substances Data) |
Bildanzeige (GHS) |
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Sicherheit |
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Chymotrypsin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R42:Sensibilisierung durch Einatmen m?glich.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24:Berührung mit der Haut vermeiden.
S22:Staub nicht einatmen.
Chemische Eigenschaften
Lyophilized powder, dialyzedVerwenden
α-Chymotrypsin from bovine has been used in a study to inform proteasome inhibition in order to advance anticancer research. α-Chymotrypsin from bovine has also been used in a study that functionalized surface anchored poly(methylhydrosiloxane) thin films on oxidized silicon wafers.Allgemeine Beschreibung
Chymotrypsin (Chymar) is extractedfrom mammalian pancreas and is used in cataractsurgery. A dilute solution is used to irrigate the posteriorchamber of the eye to dissolve the fine filaments that holdthe lens.Mechanism of action
The general mechanism for chymotrypsin is the classic serine protease mechanism. Hydrolytic proteolysis by α-chymotrypsin begins with an initial nucleophilic attack on the peptide bond by Ser 195, activated by deprotonation by His 57. This leads to forming a tetrahedral intermediate, stabilized by the amide groups of Ser 195 and Gly 193. The subsequent collapse of this intermediate, assisted by protonation of the leaving group by His 57 and Asp 102, leads to an acyl-enzyme intermediate. Activation of a water molecule by His 57 and Asp 102 facilitates hydrolysis of this intermediate, resulting in the reformation of the catalytically active serine residue and the release of the product facilitated by protonation with His 57.l?uterung methode
α-Chymotrypsin is crystallised twice from four-tenths saturated ammonium sulfate solution, then dissolved in 1mM HCl and dialysed against 1mM HCl at 2-4o. The solution is stored at 2o [Lang et al. J Am Chem Soc 80 4923 1958].Einzelnachweise
[1] R J Schilling, A K Mitra. “Degradation of insulin by trypsin and alpha-chymotrypsin.” Pharmaceutical Research 8 6 (1991): 721–7.Chymotrypsin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Chymotrypsin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 311)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Aladdin Scientific | |
tp@aladdinsci.com | United States | 52924 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
BINBO BIOLOGICAL CO.,LTD | +8618629063126 |
info@binbobiological.com | China | 435 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21632 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29869 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 1287 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 11772 | 58 |
Creative Enzymes | 1-516-855-7709 |
info@creative-enzymes.com | United States | 8748 | 58 |
9004-07-3(Chymotrypsin)Verwandte Suche:
Diethylstilbestrol
Trypsin
Proteinase, Tritirachium album-Serin-
Peptidase, Entero-
Chymotrypsinogen
Trypsin Inhibitor, pankreatischbasisch
1,1,3,3-Tetramethylbutylisocyanat
Aluminiumtris(2,4-pentandionato-O,O')
Ethylisocyanacetat
(p-Toluolsulfonyl)methylisocyanid
Kupfer(II)-4-oxopent-2-en-2-olat
N-Butylisocyanid
Benzylisocyanid
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium
2-Methylpropylisocyanid
Tris(pentan-2,4-dionato)eisen(II)
(Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II)
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium
- kimopsin
- kimoral
- quimar
- 3xcryst.
- α-chymotrypsin from human pancreas
- α-chymotrypsin tlck treated from bovine pancreas
- α-chymotrypsin, tlck treated
- CHYMOTRYPSIN I USP
- alpha-Chymotrypsin, USP grade
- a-Chymotrypsin from bovine pancreas from bovine pancreas
- ?-Chymotrypsin, USP Grade alpha-Chymotryspsin, Bovine, USP Grade
- A-chymotrypsin from human pancreas
- A-chymotrypsin sequencing grade
- A-chymotrypsin type ii from bovine*pancreas
- A-chymotrypsin type I-S from bovine*pancreas
- A-chymotrypsin type vi
- a-Chymotrypsin, Bovine Pancreas
- alpha-chymotrypsin fr.bov.pancr.free of
- gamma-chymotrypsin type ii: from*bovine pancreas
- ALPHA-CHYMOTRYPSIN FROM BOVINE PANCREAS LYO. PWD. ~60 U/MG
- ALPHA-CHYMOTRYPSIN TLCK TREATED LYOPH. 6 0 U/MG WHITE POWD.
- ALPHA-CHYMOTRYPSIN FROM BOVINE PANCREAS, ~50 U/MG
- ALPHA-CHYMOTRYPSIN FROM BOVINE PANCREAS, 25 UG
- ALPHA-CHYMOTRYPSIN FR.BOV.PANCR.FREE OF LOW MOL.WGHT.PEP.FR
- B-CHYMOTRYPSIN FROM BOVINE PANCREAS
- Gamma-ChymotrypsinExBovinePancreas
- Chymotrypsin (300 mg) (COLD SHIPMENT REQUIRED)
- CHYMOTRIPSIN
- ChyMotrypsin(bovine)/ α-ChyMotrypsin(bovine)
- Alpha-ChyMotrypsin 3x crystallized
- alpha-ChyMotrypsin,ChyMotrypsin
- ChyMotrypsin froM bovine pancreas Min. 40 U/Mg powder
- α-ChyMotrypsin, froM bovine pancreas, 1000 units/Mg
- α-ChyMotrypsin froM bovine pancreas(TLCK Treated)
- α-Chymotrypsin–acrylic beads from bovine pancreas
- recombinant chymotrypsin
- sequencing recombinant chymotrypsin
- POTASSIUM IODIDE ACS GRADE
- Sequencing Grade Recombinant Chymotrypsin
- Recombinant Human Chymotrypsin
- α-Chymotrypsin from bovine pancreas(TLCK Treated,Sequence)
- α-Chymotrypsin from porcine pancreas
- α-Chymotrypsin from bovine pancreas TLCK-Chymotrypsin
- α-Chymotrypsin from bovine pancreas(Purified)
- Sequencing Grade human chymotrypsin
- quimotrase
- zolyse
- TLCK-CHYMOTRYPSIN
- ALPHA-CHYMOTRYPSIN, TLCK TREATED
- ALPHA-CHYMOTRYPSIN TYPE I-S
- ALPHA-CHYMOTRYPSIN TYPE VI
- ALPHA-CHYMOTRYPSIN TYPE VII
- ALPHA-CHYMOTRYPSIN BOVINE PANCREAS
- BETA-CHYMOTRYPSIN
- EC: 3.4.21.1
- CHYMOTRYPSIN, BOVINE PANCREAS
- CHYMOTRYPSIN
- CHYMOTRYPSIN A