5-Chlorothiophene-2-carboxylic acid
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- CAS-Nr.
- 24065-33-6
- Englisch Name:
- 5-Chlorothiophene-2-carboxylic acid
- Synonyma:
- 5-Chlorothiophene-2-carboxylic;5-chloro-2-thiophenecarboxylicaci;5-Chlorothiophen-2-carboxylic acid;5-CHLORO-2-THIOPHENECARBOXYLIC ACID;NSC 14776;AKOS B000092;Rivaroxaban F;2-Amino-9-picoline;RARECHEM AL BE 0303;TIMTEC-BB SBB003937
- CBNumber:
- CB3189269
- Summenformel:
- C5H3ClO2S
- Molgewicht:
- 162.59
- MOL-Datei:
- 24065-33-6.mol
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5-Chlorothiophene-2-carboxylic acid Eigenschaften
- Schmelzpunkt:
- 154-158 °C(lit.)
- Siedepunkt:
- 287.0±20.0 °C(Predicted)
- Dichte
- 1.466 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.32±0.10(Predicted)
- Aggregatzustand
- Powder
- Farbe
- Cream-yellow
- BRN
- 118361
- InChI
- InChI=1S/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)
- InChIKey
- QZLSBOVWPHXCLT-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)SC(Cl)=CC=1
- CAS Datenbank
- 24065-33-6(CAS DataBase Reference)
- NIST chemische Informationen
- 5-Chloro-2-thiophenecarboxylic acid(24065-33-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36-43-36/37/38 |
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| S-S?tze: |
26-36-37/39 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
XM8400000 |
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| HazardClass |
IRRITANT |
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| HS Code |
29349990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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5-Chlorothiophene-2-carboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36:Reizt die Augen.
R43:Sensibilisierung durch Hautkontakt m?glich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
5-Chlorothiophene-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. It is also used as a ligand to synthesise the New Mono and Binuclear Ruthenium(II) Complexes[1].
Chemische Eigenschaften
White to light yellow crystal powder
Verwenden
5-Chlorothiophene-2-carboxylic acid can be used in the synthesis of the following:
- rivaroxaban, an oxazolidinone derivative used in the treatment of thromboembolic disorders
- 5-chloro-4-nitrothiophene-2-carboxylic acid, which can be used in the synthesis of thieno[2,3-b][1,4]thiapezine-5-ones
Synthese
The compound 5-chlorothiophene-2-carboxylic acid is a crucial intermediate in the synthesis of rivaroxaban. Due to its significance, numerous researchers have investigated various methods of synthesizing it. The synthesis of this compound involves the utilization of different starting materials, namely, 2-chlorothiophene, 2-chloro-5-bromothiophene, and 5-chloro-2-acetylthiophene, depending on the specific approach employed.
1. This method takes 2-chlorothiophene as an initial raw material, carrying out Friedel-crafts acylation with trichloroacetyl chloride under the action of aluminum trichloride to generate 2-trichloroacetyl-5-chlorothiophene, and then carrying out liquid alkali hydrolysis to obtain a target product.
2. This method reacts 5-chloro-2-bromothiophene with magnesium to generate a Grignard reagent, introducing carbon dioxide for inserting carbonyl and performing acid-base treatment to obtain a product.
3. 5-chloro-2-acetylthiophene is used as a raw material and is oxidized by sodium chlorite and potassium dihydrogen phosphate system to obtain a target compound.
5-Chlorothiophene-2-carboxylic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Chlorothiophene-2-carboxylic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 873)Lieferanten
24065-33-6()Verwandte Suche:
- 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
- AKOS B000092
- 2-Thiophenecarboxylic acid, 5-chloro-
- Chlorothiophene-2-carboxy
- 5-Chlorothiophene-2-carboxylic Acid, 97+%
- Rivaroxaban Impurity 40
- TIMTEC-BB SBB003937
- RARECHEM AL BE 0303
- 5-Chlorothiophene-2-carboxylicacid,98%
- 2-CHLOROTHIOPHENE-5-FORMIC ACID
- CHLOROTHIOPHENEDICARBOXYLICACID
- 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID 98%
- 5- Chlorothiophene-2-carboxilic acid
- 5-chlorothiophene-2-carboxylic acid(SALTDATA: FREE)
- Rivaroxaban Intermediate 4
- 2-Chloro-5-carboxythiophene
- NSC 14776
- ethyl 4-(3-oxoMorpholino) phenylcarbaMate
- Rivaroxaban Impurity N
- Rivaroxaban CTCA Impurity
- Rivaroxaban F
- orothiophene-2-carboxyL
- 5-Chlorothiophene-2-carboxylicAcid>
- Rivaroxaban EP Impurity F
- Rivaroxaban intermediates，5-Chloro-2-thiophenecarboxylic acid
- 5-Chlorothiophene-2-Carboxylic Acide
- 5-Chlorothiophene-2-carboxylic acid (Rivaroxaban impurity)
- Rivaroxaban Impurity C/ Rivaroxaban CTCA Impurity
- Rivaroxaban EP Impurity F/Rivaroxaban CTCA Impurity
- Rivaroxaban Intermediates 5-Chlorothiophene-2-Carboxylic Acid 24065-33-6
- 2-Amino-9-picoline
- 5-Chloro-2-carboxylic acid
- 5-chlorothiophene-2-carboxylic acidc
- 5-CHLORO-2-THIOPHENECARBOXYLIC ACID
- 5-chloro-2-thiophenecarboxylicaci
- 5-Chlorothiophene-2-carboxylic
- 5-Chlorothiophen-2-carboxylic acid
- 5-Chlorothiophene-2-Carboxylic acid (CTA)
- 5-Chloro Thiophene-2-Carboxylic Acid (5-CTC)
- 5-ChloroThiophene-2-Carboxylic acid [5CTA]
- 5-Chlorothiophene -2-Carboxylic aicd
- 24065-33-6
- 24069-33-6
- 240665-33-6
- C5H2ClO2S
- Building Blocks
- Thiophenes
- Halogenated Heterocycles
- Heterocyclic Building Blocks
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Intermediates
- Thiophene&Benzothiophene
- Miscellaneous
- Halogenated Heterocycles
- Heterocyclic Building Blocks
