Gestrinone
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- CAS-Nr.
- 16320-04-0
- Englisch Name:
- Gestrinone
- Synonyma:
- ru2323;r-2323;A-46745;Dimetrose;NeMestran;TridoMose;gestrigone;GESTRINONE;Dimetriose;gestinone.
- CBNumber:
- CB3121391
- Summenformel:
- C21H24O2
- Molgewicht:
- 308.41
- MOL-Datei:
- 16320-04-0.mol
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Gestrinone Eigenschaften
- Schmelzpunkt:
- 150-152°C
- alpha
- D20 +84.6° (c = 0.41 in methanol)
- Siedepunkt:
- 388.8°C (rough estimate)
- Dichte
- 1.1040 (rough estimate)
- Brechungsindex
- 1.4900 (estimate)
- storage temp.
- -20°C Freezer
- L?slichkeit
- DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM)
- Aggregatzustand
- A crystalline solid
- pka
- 12.76±0.40(Predicted)
- Farbe
- Off-white to light yellow
- Optische Aktivit?t
- [α]/D +81 to +88°, c =0.4 in ethanol
- Merck
- 14,4415
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1
- InChIKey
- BJJXHLWLUDYTGC-ANULTFPQSA-N
- SMILES
- C1C2C(CC[C@]3([H])C=2C=C[C@@]2(CC)[C@@]3([H])CC[C@]2(C#C)O)=CC(=O)C1
- CAS Datenbank
- 16320-04-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RTECS-Nr. |
JF7964000 |
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| Toxizit?t |
mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H360 |
Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
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| H362 |
Kann S?uglinge über die Muttermilch sch?digen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
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P201, P260, P263, P264, P270,P308+P313 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt w?hrend der Schwangerschaft /und der Stillzeit vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Gestrinone Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities.
It is reported to be useful in the treatment of endometriosis and uterine leiom yomas.
Chemische Eigenschaften
Light Yellow Solid
Verwenden
Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin.
Controlled substance.
Nebenwirkungen
Gestrinone, like danazol, inhibits the synthesis of estrogens and progestogens and has been used mainly to prepare patients with an endometrial disorder for hysterectomy. Its most common adverse effects are nausea, headache, mood changes, rash, hot flushes, weight gain, and discomfort in the joints and muscles. In some cases, there is evidence of masculinization.
Gestrinone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Gestrinone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 104)Lieferanten
16320-04-0()Verwandte Suche:
- (8s,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- 13-ETHYL-17ALPHA-HYDROXY-18,19-DINORPREGNA-4,9,11-TRIEN-20-YN-3-ONE
- D-GESTRINONE
- GESTRINONE
- 9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-19-dinorpregna-(17-alpha)-1
- ethylnorgestrienone
- gestrigone
- r-2323
- ru2323
- 13-beta-ethyl-17-alpha-ethinyl-17-hydroxy-gona-4,9,11-triene-3-one
- 13-ethyl-17-alpha-ethinyl-17-hydroxygon-4,9,11-trien-3-one
- 13-Ethyl-17α-ethynyl-17-hydroxy-4，9，11-gonatrien-3-one
- A-46745
- Dimetriose
- Dimetrose
- Nemestran：Tridomose
- (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one
- 13-Ethyl-17α-ethynyl-17β-hydroxygona-4,9,11-trien-3-one
- NeMestran
- TridoMose
- Gestrinone
(8S,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- 13-ethyl-17-hydroxy-18,19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one
- 19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-1
- 13-Ethyl-17-alpha-ethynyl-17-hydroxygon-4,9,11-trien-3-one
- Gestrinone 99%min Dimetriose
- CAS16320-04-0 Gestrinone 99%min Dimetriose
- Gestrinone USP/EP/BP
- 18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-
- Gestrinone (1.0mg/ml in Acetonitrile)
- 4, 9, 11-ESTRATRIEN-17α-ETHYLNY-18-HOMO-17β-OL-3-ONE
- gestinone.
- 13-Ethyl-17β-Hydroxy-18,19-Dinorpregna-4,9,11-Triene-20-Yn-3-One
- 16320-04-0
- C21H24O2
- Hormone
- Active Pharmaceutical Ingredients
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
