Cefotaxim-natrium
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Cefotaxim-natrium Eigenschaften
- Schmelzpunkt:
- 162-163 C
- alpha
- D20 +55±2° (c = 0.8 in water)
- Brechungsindex
- 61 ° (C=1, H2O)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
- Aggregatzustand
- powder
- Farbe
- white to yellow
- PH
- pH(100g/l, 25℃) : 4.5~6.5
- Wasserl?slichkeit
- Soluble in water.
- Merck
- 14,1933
- BRN
- 5711411
- Stabilit?t:
- Stable. Incompatible with strong oxidizing agents.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn,Xi | ||
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R-S?tze: | 42/43 | ||
S-S?tze: | 22-36/37-60-45-37-24 | ||
WGK Germany | 2 | ||
RTECS-Nr. | XI0250000 | ||
HS Code | 29419000 |
Bildanzeige (GHS) | ||||||||||||||||||||||
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Alarmwort | Achtung | |||||||||||||||||||||
Gefahrenhinweise |
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Sicherheit |
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Cefotaxim-natrium Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Cefotaxime was synthesized by Hoechst and Roussel-Uclaf in 1977. It was the first derivative of cephalosporin to introduce the methoxyimino and aminothiazole groups at the 7 position of the cephem nucleus. Although it shows unexpectedly low oral absorption, its excellent activity against a wide range of gram-positive and gram-negative organisms, including Serratia, Enterobacter, Citrobacter, and anaerobes, guided research and development of the newer synthetic cephems, the so-called thirdgeneration cephalosporins.Chemische Eigenschaften
White to pale yellow crystalline powderVerwenden
Cefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.Definition
ChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standardsClinical Use
Cefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant.The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor.
Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.
Cefotaxim-natrium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Lithium tert-butoxide
Triethylammoniumchlorid
Natriumacetat
n-Hexan
Ethanol
N,N-Dimethylformamid
Aceton
(Z)-2-Amino-α-(methoxyimino)thiazol-4-essigsure
Pentachlorphosphoran
Ethylacetat
Dichlormethan
Thiazol
Methanol
2-Aminoacetamid
N,N-Dimethylacetamid
1-Butanol
Natriumhydrogencarbonat
Downstream Produkte
Cefotaxim-natrium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 663)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12825 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5893 | 58 |
Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 |
hbjbtech@163.com | China | 1000 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 1015 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
Hebei Longbang Technology Co., LTD | +86-18633929156 +86-18633929156 |
admin@hblongbang.com | China | 942 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 |
L18532138899@163.com | China | 939 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21639 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
64485-93-4(Cefotaxim-natrium)Verwandte Suche:
2-Amino-α-oxothiazol-4-essigsure
Natriumhydrogencarbonat
Natriumhydroxid
Natriumchlorid
Trinatriumcitrat
Natriumacetat
Paracetamol
Trinatriumorthophosphat
Cefotaxime
(o-(-2,6-Dichloranilino)phenyl)-essigs?ure, Natrium-Salz
Cefalotinnatrium
Cefalotin
2-Acetamidoacrylsure
Natriumdichromat Dihydrat
Natriumformiat
Sauerstoff
(6R-trans)-7-Amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure
(6R-trans)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure
- Cefotaxime:Claforan
- FIR-756
- (6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
- (6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
- Cefotaxime sodium salt,Cefotaxim sodium salt
- Cefotaxime Sodium (250 mg)J0C189901ug/mg(ai)
- Cefotaxime Sodium (250 mg)
- CefotaxiMe sodiuM API
- CefotaxiMe sodiuM(Claforan
- CefotaxiMe-Na-salt research grade
- AXIME SODIUM SALT
- Cefotaxime Sodium for Injection
- CEFOTAXIME SODIUM
- (((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-,(6r-(6-alpha,7-beta
- (z))),sodiumsalt
- 2,0)oct-2-ene-2-carboxylicacid,3-((acetyloxy)methyl)-7-5-thia-1-azabicyclo(
- 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylicacid,3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-,[6R-(6-.alpha.,7-.beta.(Z))],sodiumsalt
- hr756
- ru24756
- sodium7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate
- sodium salt of 7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7 (Z)-(O-methyloxime), acetate (ester)
- sodium [6R-[6alpha,7beta(Z)]]-3-(acetoxymethyl)-7-[(2-aminothiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- 7-[2-(2-AMINO-4-THIAZOLYL)GLYOXYLAMIDO]-3-(HYDROXYMETHYL)-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE 7(2)-(Z)-(O-METHYLOXIME) ACETATE, NA
- [6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt
- Cefotaxime sodium sterile USP/EP/JP
- 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 3-(acetyloxy)methyl-7-(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetylamino-8-oxo-, monosodium salt, (6R,7R)-
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodium salt, [6R-[6α,7β(Z)]]-
- Cefotax
- Chemcef
- Pretor
- Tolycar
- Cefotaxime Na
- Cefotaxime free acid
- Cefotaxime sodium sterile IP/Bp
- CEFOTAXIME, SODIUM PLANT CELLCULTURE TES TED
- CefotaximeSodiumSterileUsp24
- (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt
- [6R-[6α,7β(Z)]]-3-[(Acetyloxy)methyl]-7-[2-(2-amino-4-thiazolvl)-2-(methoxyimino)aeetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
- Sodium salt (syn-isomer)
- Cefotaxime (Drug Substance)
- Ceftazidime Solution, 100ppm
- Cefotaxime sodium salt, 92%, a third-generation cephalosporin antibiotic
- Pharmaceutical Raw Material Cefotaxime Sodium Cas:64485-93-4
- ([6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt
- Cefotaxime sodium salt, ≥98%(HPLC)
- sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- HR-756 (sodium salt)
- Cefotaxime for peak identification CRS
- Cefotaxime sodium CRS
- Pharmaceutical Raw Material Cefotaxime Sodium
- Sodium (6R,7R)-3-(acetoxymethyl)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- 1214984-50-5 (Sodium salt)
- hot selling Cefotaxime Sodium
- Cefotaxime sodium USP/EP/BP
- (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- Cefotaxime sodium salt 13CD3
- Cefotaxime sodiumQ: What is Cefotaxime sodium Q: What is the CAS Number of Cefotaxime sodium Q: What is the storage condition of Cefotaxime sodium Q: What are the applications of Cefotaxime sodium
- Cefotaxime sodium salt, plant cell culture tested, powder