2-(Diethylamino)ethyl-4-amino-3-butoxybenzoathydrochlorid
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- CAS-Nr.
- 5987-82-6
- Bezeichnung:
- 2-(Diethylamino)ethyl-4-amino-3-butoxybenzoathydrochlorid
- Englisch Name:
- Benoxinate Hydrochloride
- Synonyma:
- β;D01768;novesin;Benoxil;lacrimin;cebesine;novesine;Novesina;dorsacaine;conjuncain
- CBNumber:
- CB1476374
- Summenformel:
- C17H29ClN2O3
- Molgewicht:
- 344.88
- MOL-Datei:
- 5987-82-6.mol
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2-(Diethylamino)ethyl-4-amino-3-butoxybenzoathydrochlorid Eigenschaften
- Schmelzpunkt:
- 157-160 C
- storage temp.
- 2-8°C
- L?slichkeit
- Very soluble in water, freely soluble in ethanol (96 per cent).
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Merck
- 13,1045
- InChI
- InChI=1S/C17H28N2O3.ClH/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3;/h8-9,13H,4-7,10-12,18H2,1-3H3;1H
- InChIKey
- PRGUDWLMFLCODA-UHFFFAOYSA-N
- SMILES
- C1(C(=O)OCCN(CC)CC)=CC=C(N)C(OCCCC)=C1.Cl
- CAS Datenbank
- 5987-82-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,Xn |
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| R-S?tze: |
36/37/38-20/21/22 |
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| S-S?tze: |
22-26-36 |
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| RIDADR |
UN 1544PSN2 6.1 / PGIII |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DG1502900 |
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| HS Code |
29225000 |
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| Toxizit?t |
LD50 scu-rat: 60 mg/kg NIIRDN 6,154,82 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2-(Diethylamino)ethyl-4-amino-3-butoxybenzoathydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, crystalline powder or colourless crystals.
Verwenden
Benoxinate Hydrochloride is a local anesthetic used in ophthalmology to numb the surface of the eye for a variety of procedures.
Definition
ChEBI: The monohydrochloride salt of oxybuprocaine.
Clinical Use
Benoxinate hydrochloride is a topical anesthetic. Benoxinate hydrochloride ophthalmic solution, 0.4%, was originally permitted in 1953 as Dorsacaine under NDA 08-729. The product was reviewed as part of the Drug Efficacy Study Implementation (DESI), found to be effective, approved and marketed by Dorsey until 1980. An abbreviated new drug application (ANDA) was also approved [Sola Barnes Hind (ANDA 84-149)] and marketed until 1991.
Nebenwirkungen
The most common ocular adverse events associated with Benoxinate Hydrochloride when used as an eye drop ingredient (Fluorescein and Benoxinate Ophthalmic Solution) were: stinging, burning and conjunctival redness. Serious adverse reactions include corneal toxicity and corneal damage due to insensitivity. Other possible side effects include eye congestion, burning, stinging, eye irritation, blurred vision and punctate keratitis.
Sicherheitsprofil
Poison by subcutaneous route. A topical anesthetic. When heated to decomposition it emits toxic fumes of NOx and HCl.
2-(Diethylamino)ethyl-4-amino-3-butoxybenzoathydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(Diethylamino)ethyl-4-amino-3-butoxybenzoathydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 173)Lieferanten
5987-82-6(2-(Diethylamino)ethyl-4-amino-3-butoxybenzoathydrochlorid)Verwandte Suche:
- 2-(DIETHYLAMINO)ETHYL 4-AMINO-3-BUTOXYBENZOATE HYDROCHLORIDE
- 4-AMINO-3-BUTOXYBENZOIC ACID DIETHYLAMINOETHYL ESTER HYDROCHLORIDE
- BENZOIC ACID, 4-AMINO-3-BUTOXY-, 2-(DIETHYLAMINO)ETHYL ESTER, MONOHYDROCHLORIDE
- BENOXINATE HCL
- BENOXINATE HYDROCHLORIDE
- OXYBUPROCAINE HYDROCHLORIDE
- cebesine
- conjuncain
- dorsacaine
- dorsacainehydrochloride
- lacrimin
- novesin
- novesine
- ethyl 4-amino-3-butoxybenzoate hydrochloride
- Oxybuprocaine HCL
- BENOXINATE USP HYDROCHLORIDE
- BENOXINATE HYDROCHLORIDE USP
- BENOXINATE HYDROCHLORIDE CRYSTALLINE
- OxybuprocainHCl
- Oxybuprocainhydrochlorid
- 2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride, 4-Amino-3-butoxybenzoic acid diethylaminoethyl ester
- Benoxil
- Conjucaine
- Benoxil (tn)
- D01768
- Oxybuprocaine hydrochloride (jp15)
- Benoxinate Hydrochloride (200 mg)
- 2-(4-amino-3-butoxy-benzoyl)oxyethyl-diethyl-ammonium chloride
- 2-(4-amino-3-butoxybenzoyl)oxyethyl-diethylazanium chloride
- 2-(4-amino-3-butoxy-phenyl)carbonyloxyethyl-diethyl-azanium chloride
- BENZOIC ACID, 4-A
- EINECS 227-808-8
- Minims Benoxinate
- Novesina
- Opulets Benoxinate
- Oxbarukain
- Benoxinate HCl USP
- Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
- 2-[(4-amino-3-butoxyphenyl)-oxomethoxy]ethyl-diethylammonium chloride
- 4-Amino-3-butoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
- Benoxinate hydrochL
- Procaine Impurity 9 (Benoxinate Hydrochloride)
- Oxybuprocain hydrochloride
- TIANFU-CHEM Oxybuprocaine hydrochloride
- Benoxinate Hydrochloride (1050009)
- β
- β-Dimethylacrylshikonin
- Oxybuprocaine
Hydrochloride /
Benoxinate
Hydrochloride
- 5987-82-6
- 59878-28-6
- C17H28N2O3xHCL
- C17H28N2O3HCl
- AVIOCHINA
