3-(10,11-Dihydro-5H-dibenzo(a,d)-cyclohepten-5-yliden)-N,N-dime-thyl-1-propanamin-hydrochlorid
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3-(10,11-Dihydro-5H-dibenzo(a,d)-cyclohepten-5-yliden)-N,N-dime-thyl-1-propanamin-hydrochlorid Eigenschaften
- Schmelzpunkt:
- 196-197°C
- Flammpunkt:
- 11 °C
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: soluble
- Aggregatzustand
- powder
- pka
- 9.4(at 25℃)
- Farbe
- white to off-white
- PH
- 4.5~6.0 (10g/l, 25℃)
- Wasserl?slichkeit
- almost transparency
- Merck
- 14,487
- BCS Class
- 1
- CAS Datenbank
- 549-18-8(CAS DataBase Reference)
- EPA chemische Informationen
- Amitriptyline hydrochloride (549-18-8)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T,F,N,Xn | ||
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R-S?tze: | 23/24/25-36/37/38-42/43-63-39/23/24/25-11-50/53-36-22 | ||
S-S?tze: | 22-26-36/37/39-45-36/37-16-61-60-7 | ||
RIDADR | UN 2811 6.1/PG 3 | ||
WGK Germany | 3 | ||
RTECS-Nr. | HO9450000 | ||
TSCA | Yes | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 29214990 | ||
Toxizit?t | LD50 in mice, rats (mg/kg): 350, 380 orally; 65, 75 i.p. (Tobe) |
Bildanzeige (GHS) |
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Alarmwort | Achtung | ||||||||||||||||||||||||||||
Gefahrenhinweise |
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Sicherheit |
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3-(10,11-Dihydro-5H-dibenzo(a,d)-cyclohepten-5-yliden)-N,N-dime-thyl-1-propanamin-hydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R11:Leichtentzündlich.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
Amitriptyline (hydrochloride) (CRM) (Item No. 19031) is a certified reference material categorized as a tricyclic antidepressant. This product is intended for analytical forensic applications. This product is also available as a general research tool .Chemische Eigenschaften
White to Off-White SolidVerwenden
Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.Allgemeine Beschreibung
Amitriptyline, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride,5-(3-dimethylaminopropylidene)-10,11-dihydro-5Hdibenzo[a,d]cycloheptene hydrochloride (Elavil), is one ofthe most anticholinergic and sedative of the TCAs. Becauseit lacks the ring-electron–enriching nitrogen atom ofimipramine, metabolic inactivation mainly proceeds not at theanalogous 2-position but at the benzylic 10-position (i.e.,toluene-like metabolism predominates). Because of the 5-exocyclic double bond, E- and Z-hydroxy isomers are producedby oxidation metabolism. Conjugation produces excretablemetabolites. As is typical of the dimethyl compounds,N-demethylation occurs, and nortriptyline is produced, whichhas a less anticholinergic, less sedative, and more stimulantaction than amitriptyline. Nortriptyline is a SNERI; thecomposite action of drug and metabolite is nonselective.Sicherheitsprofil
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: convulsions, respiratory depression, changes in sleep, hallucinations, muscle contractions, somnolence, blood pressure decrease, coma, cyanosis, dyspnea, and ataxia. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Used in the treatment of depression. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also ELAVIL.3-(10,11-Dihydro-5H-dibenzo(a,d)-cyclohepten-5-yliden)-N,N-dime-thyl-1-propanamin-hydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
4-Methylen-2-oxetanon
Amitriptylin
Diethylether
Ammoniumchlorid
Dilute hydrochloric acid
Diphosphorpentaoxid
Phenylessigsure
Wasserstoff
Hydrogenchlorid
Phthalsureanhydrid
3-Chlorpropyl(dimethyl)amin
Downstream Produkte
3-(10,11-Dihydro-5H-dibenzo(a,d)-cyclohepten-5-yliden)-N,N-dime-thyl-1-propanamin-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 447)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 |
allison@yan-xi.com | China | 5855 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29792 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21632 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
FandaChem@Gmail.com | China | 7738 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29871 | 58 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 18526 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
549-18-8(3-(10,11-Dihydro-5H-dibenzo(a,d)-cyclohepten-5-yliden)-N,N-dime-thyl-1-propanamin-hydrochlorid)Verwandte Suche:
Rimantadine
Dimethylcarbonat
Dimethylsulfat
Dimethylsulfoxid
Ethan
Dimethyl sebacate
Topotecan hydrochloride
Dimethyl ether
N,N-Dimethylformamid
Dimethylfumarat
Dimethylsulfid
Isopropylamin
2,6-Dimethyloct-7-en-2-ol
Yohimbinhydrochlorid
Amitriptylin
Amphetamin
Sibutramine hydrochloride
Nortriptylin
- Amiplin
- Normaln
- Methanol (test Amitriptyline HCl, 1.0 mg/mL as free base)
- 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
- Amitriptyline hydrochloride 98+%
- Amitriptyline hydrochloride solution
- 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
- Endep hydrochloride
- Levate hydrochloride
- LABOTEST-BB LT00244837
- LABOTEST-BB LT00159907
- 3-(10,11-dihydro-5h-dibenzo[a,d]cycloheptene-5-ylidene)-n,n-dimethyl-1-propanamine hydrochloride
- AMITRIPTYLINE HYDROCHLORIDE
- 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride
- AMITRYPTILLINE HCL
- AMITRIPTYLINE HYDROCHLORIDE, PHARMA
- 1-Propanamine, 3-(10,11-dihydro-5H-dibenzoa,dcyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride
- AMITRIPTYLINEHYDROCHLORIDE,USP
- 1-propanamine, 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n,n-dimet 10,11-dihydro-n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-pro pylamine hcl 5-(3-dimethylaminopropylidene)dibenzo(a,d)(1,4)cycloheptadiene hydrochloride amitriptyline chloride
- 10,11-dihydro-n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5,gamma)-pro
- 1-propanamine,3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n,n-dimet
- 5-(3-dimethylaminopropylidene)dibenzo(a,d)(1,4)cycloheptadienehydrochloride
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- Amitriptyline HydrochlorideQ: What is Amitriptyline Hydrochloride Q: What is the CAS Number of Amitriptyline Hydrochloride Q: What is the storage condition of Amitriptyline Hydrochloride Q: What are the applications of Amitriptyline Hydrochloride
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