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1-AdaMantanethylaMine

1-AdaMantanethylaMine Struktur
13392-28-4
CAS-Nr.
13392-28-4
Englisch Name:
1-AdaMantanethylaMine
Synonyma:
RIMANTADINE;LEVOFLOXACIN HCL;RiMantidine;1-Adamantanemethylamine;RiMantadine (FluMadine);1-Adaman;AKOS B022266;1-Rimantadine;AKOS NCG1-0034;1-Adamantanethylamine
CBNumber:
CB7122907
Summenformel:
C12H21N
Molgewicht:
179.3
MOL-Datei:
13392-28-4.mol

1-AdaMantanethylaMine Eigenschaften

Siedepunkt:
248°C
Dichte
1.033
Flammpunkt:
99°C
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
Liquid
pka
11.17±0.29(Predicted)
Farbe
Colorless to light yellow
CAS Datenbank
13392-28-4(CAS DataBase Reference)
NIST chemische Informationen
1-Adamantanemethylamine, «alpha»-methyl-(13392-28-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HazardClass  IRRITANT
HS Code  2902190000
Giftige Stoffe Daten 13392-28-4(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

1-AdaMantanethylaMine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Rimantadine act by blocking the M2 ion channel which is required for uptake of protons into the interior of the virus to permit acid-promoted viral uncoating (decapsidation).

Allgemeine Beschreibung

Resistant variants of influenza type A have been recoveredfrom rimantadine-treated patients.Resistance with inhibitory concentrations increased morethan 100-fold have been associated with single nucleotidechanges that lead to amino acid substitutions in the transmembranedomain of M2. rimantadineshare cross-susceptibility and resistance.

Pharmazeutische Anwendungen

An analog of amantadine, supplied as the hydrochloride for oral administration.

Mechanism of action

Rimantadine hydrochloride (α-methyl-1-adamantanemethylamine hydrochloride) is a synthetic adamatane derivative that is structurally and pharmacologically related to amantadine. It appears to be more effective than amantadine hydrochloride against influenza A, with fewer CNS side effects. Rimantadine hydrochloride is thought to interfere with virus uncoating by inhibiting the release of specific proteins. It may act by inhibiting RT or the synthesis of virus-specific RNA, but it does not inhibit virus adsorption or penetration. It appears to produce a virustatic effect early in the virus replication. It is used widely in Russia and Europe.

Pharmakokinetik

Oral absorption: >90%
Cmax 100 mg oral (every 12 h): 0.4–0.5 mg/L after 2–6 h
Plasma half-life: c. 35 h
Volume of distribution: Very large
Plasma protein binding: c. 40%
Absorption and distribution
Single- and multiple-dose pharmacokinetic studies in elderly patients and young adults are remarkably similar. The steadystate concentration in nasal mucus develops by day 5 at a concentration approximately 1.5-fold higher than plasma.
Metabolism
In contrast to amantadine, rimantadine is extensively metabolized in the liver by hydroxylation and glucuronidation.
Excretion
Less than 20% is excreted unchanged in the urine and most of the breakdown products are excreted by this route. Thus, the plasma half-life is much less affected by renal dysfunction than that of amantadine.

Clinical Use

Prophylaxis and treatment of influenza A H1N1 infections Since prolonged administration is well tolerated by elderly patients, the drug is preferable to amantadine.

Nebenwirkungen

Rimantadine has significantly fewer side effects than amantadine at equivalent doses, perhaps because of differences in pharmacokinetics, since with equal doses the blood levels are considerably lower. CNS side effects are not significantly higher than placebo.

1-AdaMantanethylaMine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1-AdaMantanethylaMine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 251)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8806 58
Hebei Mujin Biotechnology Co.,Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12831 58
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 8771 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29879 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051
joe@yuhengpharm.com CHINA 21142 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58

13392-28-4()Verwandte Suche:


  • 1-Adamantan-1-ylethylamine
  • 1-Adamantanethylamine
  • Rimantadine & Rimantadine Hydrochloride
  • 1-(adaMantan-1-yl)ethanaMine hydrochloride
  • 1-(AdaMantan-1-yl)ethanaMine
  • 1-Adaman
  • 1-ADAMANTANEMETHYLAMINE, alpha-METHYL-, HYDROCHLORIDE
  • Adamantane, 1-(1-aminoethyl)-, hydrochloride
  • Rimantadine hydrochloride [USAN]
  • Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-, hydrochloride (9CI)
  • α-Methyl-1-adamantanemethylamine
  • 1-(1-Adamantyl)ethanamine
  • 1-Adamantanemethylamine, alpha-methyl-
  • alpha-Methyl-1-adamantanemethylamine
  • alpha-Methyladamantanemethylamine
  • Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-
  • Tricyclo[3,3,1,1(3,7)]decane-1-methanamine, alpha-methyl-
  • 1-(1-ADAMANTYL)ETHYLAMINE
  • AKOS NCG1-0034
  • AKOS B022266
  • Levofloxacine Hydrochloride
  • Flunarizine hydrochloride cp2000,BP98
  • Rimantadine (base and/or unspecified salts)
  • α-Methyl-1-adamantanemethanamine
  • (1R)-1-(1-adamantyl)ethanamine
  • 1-Rimantadine
  • Tricyclo[3.3.1.13,7]decane-1-methanamine, α-methyl-
  • 1-AdaMantanethylaMine USP/EP/BP
  • RiMantadine (FluMadine)
  • RiMantidine
  • RIMANTADINE
  • LEVOFLOXACIN HCL
  • 1-Adamantanemethylamine
  • 13392-28-4
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics G-M
  • BioChemical
  • Adamantane derivatives
  • API's
  • Inhibitors
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