Moclobemide
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Moclobemide Eigenschaften
- Schmelzpunkt:
- 137°C
- Siedepunkt:
- 447.7±40.0 °C(Predicted)
- Dichte
- 1.206±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: >20mg/mL
- pka
- 14.26±0.46(Predicted)
- Aggregatzustand
- solid
- Farbe
- white
- Merck
- 14,6226
- CAS Datenbank
- 71320-77-9(CAS DataBase Reference)
- NIST chemische Informationen
- Moclobemide(71320-77-9)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn,T+ | ||
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R-S?tze: | 22-37/38-41-26/27/28 | ||
S-S?tze: | 26-39-45-36/37/39-22 | ||
RIDADR | 3249 | ||
WGK Germany | 2 | ||
RTECS-Nr. | CV2462000 | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 29349990 | ||
Giftige Stoffe Daten | 71320-77-9(Hazardous Substances Data) | ||
Toxizit?t | LD50 in rats (mg/kg): 707 orally (Burkard, Wyss) |
Bildanzeige (GHS) |
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Sicherheit |
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Moclobemide Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augensch?den.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S39:Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Beschreibung
Moclobemide is the first of a new generation of non-hydrazine, reversible MAO-A inhibitors useful in the treatment of depression. Moclobemide is a selective inhibitor of MAO-A, allowing tyramine to be metabolized by MAO-B. In controlled studies, moclobemide was clinically superior to desipramine and showed no cholinergic or cardiovascular side-effects. A metabolite is currently under investigation for treatment of Parkinson’s disease,.Chemische Eigenschaften
White to Off-White SolidDefinition
ChEBI: A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.Arzneimittelwechselwirkung
Drug interactions for the RIMAs include interaction with SSRI antidepressants, which can cause the 5-HT syndrome. The effect of stimulant drugs, such as methylphenidate and dextroamphetamine (used to treat ADHD), may be increased. Some over-the-counter cold and hay fever decongestants (i.e., sympathomimetic amines) can have increased stimulant effects. Selegiline, a selective MAO-B used for Parkinson's disease, should not be used concurrently with the RIMAs. Unlike the irreversible MAOIs, no significant interactions with foods occur, because the selective inhibition of MAO-A does not stop the metabolism of tyramine. The RIMAs must not be taken concurrently with a nonreversible MAOI.Moclobemide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Chlorsure
Acrylamid
N,N-Diethylethanamin
4-Chlorbenzoesure
Ethyl-chlorformiat
2-Bromethylammoniumbromid
Propionamid
4-Chlorbenzoylchlorid
Propan-2-ol
Downstream Produkte
Moclobemide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 294)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Jinan Jianfeng Chemical Co., Ltd | +86-0531-88110457 +86-15562555968 |
info@pharmachemm.com | China | 334 | 58 |
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 146 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 615 | 58 |
Xi an Biohorlden Industry Trade Co Ltd | +86-18829283179 +86-13636819721 |
sales@horlden.com | China | 236 | 58 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29858 | 58 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 |
sales@amoychem.com | China | 6383 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49732 | 58 |
71320-77-9()Verwandte Suche:
5-Methyl-3-isoxazolcarbons?ure-2-(phenylmethyl)hydrazid
Minoxidil
1-(4,4-Bis(4-fluorphenyl)butyl)-4-(4-chlor-3-(tri-fluormethyl)phe-nyl)-4-piperidinol
Citalopram
Trazodon
Benzamid
CHLOANTRANILIPROLE
p-Aminobenzamid
Chlordifluormethan
4-t-Butylbenzamide
- moclbemide
- 4-CHLORO-N[2-(4-MORPHOLINYL)ETHYL]-BENZAMIDE (MOCLOBEMIDE)
- Ro-11-1163, Aurorix, Manerix, Moclamine, p-Chloro-N-(2-morpholinoethyl)benzamide
- MODOBEMDE
- p-Chlor-N-(2-morpholinoethyl)benzamid
- 4-Chloro-(2-(4-morpholinyl)ethyl)benzamide
- Moclobemide (base and/or unspecified salts)
- 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide, Aurorix, Moclamine
- 4-Chloro-N-[2-(4-motpholinyl)ethyl]benzamide
- Manefix
- Moclamine
- 4-Chloro-N-(2-morpholin-4-ylethyl)benzamide
- p-chloro-n-(2-morpholinoethyl)benzamide
- MOCLOBEMIDE
- manerix
- aurorix
- BENZAMIDE, 4-CHLORO-N-[2-(4-MORPHOLINYL)ETHYL]-
- 4-chloro-n-(2-(4-morpholinyl)ethyl)-benzamid
- 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide
- Moclaime
- Moclamide
- RO 11-1163
- ro11-1163
- Ro-11-1163/000
- CS-1682
- MOCLOBAMIDE
- Moclobemide USP/EP/BP
- 4-chloro-N-(2-morpholinoethyl)benzamide
- Moclobemide (Ro 111163)
- Moclobemide in methanol
- Moclobemide, 10 mM in DMSO
- Moclobemide - Bio-X ?
- 71320-77-9
- 71320-77-7
- API's
- All Inhibitors
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Other APIs
- Active Pharmaceutical Ingredients
- Monoamine Oxidase