965-52-6
965-52-6 結(jié)構(gòu)式
基本信息
硝呋酚酰肼
硝呋齊特
BENZOIC ACID, 4-HYDROXY-, [(5-NITRO-2-FURANYL)METHYLENE]HYDRAZIDE
NIFUROXAZIDE
p-hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide
(nitro-5’furfurylidene-2’)hydroxy-4benzhydrazide
4-hydroxy-benzoicaci((5-nitro-2-furanyl)methylene)hydrazide
diarlidan
dicoferin
ercefurol
ercefuryl
nifuroxazid
p-hydroxy-benzoicaci(5-nitrofurfurylidene)hydrazide
r.c.27-109
NIFUROXAZIDE VETRANAL, 250 MG
4-Hydroxybenzoic acid-[[5-nitro-2-furanyl] methylene] hydrazide
nitrofuroxazide
(5-Nitro-2-furfurylidene)(4-hydroxybenzoyl)hydrazine
4-Hydroxybenzoic Acid 2-[(5-Nitro-2-furanyl)methylene]hydrazide
Adral
Bacifurane
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
應(yīng)用領(lǐng)域
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | N1181 | 硝呋齊特 Nifuroxazide | 965-52-6 | 100MG | 85元 |
| 2024/11/08 | HY-B1436 | 硝呋酚酰肼 Nifuroxazide | 965-52-6 | 200mg | 500元 |
| 2024/11/08 | N1181 | 硝呋齊特 Nifuroxazide | 965-52-6 | 500MG | 175元 |
常見問題列表
| Target | Value |
| STAT1 | |
| STAT3 | |
| STAT5 |
Nifuroxazide是硝基呋喃類化合物抑制劑,抑制STAT轉(zhuǎn)錄因子的信號轉(zhuǎn)導(dǎo)。 Nifuroxazide通過減少Jak激酶自身磷酸化阻礙了STAT3組成型磷酸化，從而降低骨髓瘤細(xì)胞存活性，而不影響正常的外周血單核細(xì)胞。 Nifuroxazide能夠降低Jak和TYK2的酪氨酸磷酸化，而對EGF受體酪氨酸激酶或Src激酶沒有影響，表明Nifuroxazide對Jak2和TYK2的相對特異性。 Nifuroxazide對 Akt 或 MAPK 磷酸化作用沒有抑制。 Nifuroxazide通過減少Jak激酶自身磷酸化抑制STAT3在MM細(xì)胞中的組成型磷酸化，并導(dǎo)致STAT3的靶基因Mcl-1下調(diào)。 Nifuroxazide會(huì)引起包含STAT3活化的初級骨髓瘤細(xì)胞和骨髓瘤細(xì)胞系的存活性降低，但不影響正常外周血單核細(xì)胞。雖然骨髓基質(zhì)細(xì)胞為骨髓瘤細(xì)胞提供存活信號，但nifuroxazide會(huì)阻斷這個(gè)生存優(yōu)勢。相對于STAT3與其他細(xì)胞通路的相互作用，nifuroxazide與組蛋白去乙?；敢种苿┛s肽或MEK抑制劑UO126結(jié)合時(shí)會(huì)顯示出更強(qiáng)的細(xì)胞毒性。
Compared with the vehicle group, treatment with Nifuroxazide could inhibit tumor growth and tumor weight in a dose-dependent manner, with the inhibition rate of tumor volumes being 43.0% and 62.1% at 25 mg/kg and 50 mg/kg, respectively. It is also shown that Nifuroxazide significantly inhibits the proliferation of nuclear Ki-67-positive cells and induces apoptosis cells of cleaved caspase-3-positive cells. Besides, it is found that treatment with Nifuroxazide could inhibit the expression of MMP-2, MMP-9 and p-Stat3 in A375 tumor tissues. What’s more, Nifuroxazide inhibits the infiltration of MDSCs into the lung, which might be associated with suppression of distant colonization of tumor cells in B16-F10 melanoma metastasis model.