57-64-7
中文名稱
吡咯他尼雜質(zhì)A
英文名稱
PHYSOSTIGMINE SALICYLATE
CAS
57-64-7
EINECS 編號
200-343-8
分子式
C22H27N3O5
MDL 編號
MFCD00135659
分子量
413.47
MOL 文件
57-64-7.mol
更新日期
2024/12/31 09:17:00
57-64-7 結(jié)構(gòu)式
基本信息
中文別名
水楊酸毒扁豆堿吡咯他尼雜質(zhì)A
水楊酸毒豆堿
毒扁豆堿水楊酸鹽
柳酸毒扁豆堿
水楊酸依色林
英文別名
ESERINE MONOSALICYLATEESERINE SALICYLATE
ESERINE SALICYLATE SALT
PHYSOSTIGMINE SALICYLATE
PHYSOSTIGMINE SALICYLATE SALT
2-hydroxy-,compd.with(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci
ar-44
physostigmine,[salicylate(1:1)]
physostigmine,salicylate(1:1)
physostolsalicylate
salicylicacid,compd.withphysostigmine(1:1)
tl-1380
trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1)
ESERINE SALICYLATE 99.9%
Physostigmine monosalicylate
Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1)
PHYSOSTIGMINESALICYLATE,USP
ESERINE SALICYLATE(RG)
Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI)
Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
所屬類別
原料藥：擬膽堿藥物理化學性質(zhì)
熔點181-183 °C
儲存條件-20°C
溶解度DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
酸度系數(shù)(pKa)pKa 1.96/8.08(H2O,t =15) (Uncertain)
形態(tài)neat
顏色White to yellow
Merck7384
BRN3900576
InChIKeyHZOTZTANVBDFOF-DPKVYHSMNA-N
SMILESC12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|
CAS 數(shù)據(jù)庫57-64-7(CAS DataBase Reference)
EPA化學物質(zhì)信息Physostigmine salicylate (57-64-7)
吡咯他尼雜質(zhì)A價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-B1266 | 吡咯他尼雜質(zhì)A Physostigmine salicylate | 57-64-7 | 5mg | 1400元 |
| 2024/11/08 | HY-B1266 | 吡咯他尼雜質(zhì)A Physostigmine salicylate | 57-64-7 | 10mg | 2300元 |
| 2024/11/08 | HY-B1266 | 吡咯他尼雜質(zhì)A Physostigmine salicylate | 57-64-7 | 25mg | 4600元 |
常見問題列表
生物活性
Physostigmine salicylate (Eserine salicylate) 是一種可逆的乙酰膽堿酯酶 (AChE) 抑制劑。Physostigmine salicylate 可以透過血腦屏障并刺激中樞膽堿能神經(jīng)傳遞。Physostigmine salicylate 能逆轉(zhuǎn)阿爾茨海默病轉(zhuǎn)基因小鼠的記憶缺陷。Physostigmine salicylate 也是抗膽堿能中毒的解毒劑。體內(nèi)研究
Physostigmine salicylate (Eserine salicylate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.
Physostigmine salicylate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.
| Animal Model: | Heterozygous transgenic mice (Tg(+) mice) |
| Dosage: | 0.03, 0.1, and 0.3 mg/kg |
| Administration: | SC; daily for 6 weeks |
| Result: | Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals. |