475-83-2
基本信息
荷葉堿
荷葉黃銅
G)喹啉
荷葉堿提取物
荷葉堿[葉]
天然荷葉提取物
荷葉堿(液相2)
荷葉堿(標準品)
荷葉提取物 荷葉堿
VLT 049
Nuciferi
nuciferin
NUCIFERINE
Sanjoinine
fettuccine
l-nuciferine
Sanjoinine E
(R)-Nuciferine
物理化學性質
安全數據
常見問題列表
中醫(yī)學認為,荷葉性味苦澀,平,歸肝、脾、胃、心經。有清暑利濕、升發(fā)清陽、涼血止血等功效。荷葉的主要化學成分有荷葉堿、檸檬酸、草酸等,起主要減肥作用的是荷葉堿,藥理研究表明,荷葉具有利尿通便、通腸毒、降脂除油、清暑解熱等作用,能明顯降低血清中甘油三醇和膽固醇含量,具有調節(jié)血脂的保健作用。采用荷葉減肥不需要刻意節(jié)食,對人體無任何副作用。
5-HT 2C Receptor 131 nM (IC 50 ) |
5-HT 7 Receptor 150 nM (IC 50 ) |
5-HT 2A Receptor 478 nM (IC 50 ) |
5-HT 2B Receptor 1 μM (IC 50 ) |
5-HT 6 Receptor 700 nM (EC 50 ) |
5-HT 1A Receptor 3.2 μM (EC 50 ) |
D 2 Receptor 64 nM (EC 50 ) |
D 4 Receptor 2 μM (EC 50 ) |
D 5 Receptor 2.6 μM (EC 50 ) |
Nuciferine is a partial agonist at DD 2 receptor with an activity (E max =67% of dopamine) similar to aripiprazole (E max =50% of dopamine). In line with its partial agonist activity, Nuciferine inhibited dopamine-induced activation of G i with a potency similar to clozapine (Nuciferine K B =62 nM; Clozapine K B =20 nM) as determined via Schild regression analysis. The natural product Nuciferine acts as an effective inhibitor of adult worm motility. Nuciferine is effective at inhibiting both basal and 5-HT evoked motility of adult schistosomes. Nuciferine inhibits Sm.5HTR L and schistosomule with 0.24±0.04 and 0.62±0.22 μM, respectively.
In rodent models relevant to antipsychotic drug action, Nuciferine blocks head-twitch responses and discriminative stimulus effects of a 5-HT 2A agonist, substituted for clozapine discriminative stimulus, enhanced amphetamine induced locomotor activity, inhibited phencyclidine (PCP)-induced locomotor activity, and rescued PCP-induced disruption of prepulse inhibition without induction of catalepsy. In the presence of 1 or 3 mg/kg Nuciferine, cumulative PCP doses produce similar substitution to PCP alone. In the clozapine-trained animals, a dose-dependent substitution for 1.25 mg/kg clozapine is seen at 10 mg/kg Nuciferine (80.63% drug lever responding), with an ED 50 value of 5.42 mg/kg (95% CI 3.09-9.48 mg/kg) while the lower doses tested (0.1 mg/kg-3 mg/kg) fails to produce substitution for clozapine’s discriminative cue. In addition to a high percentage of responding on the clozapine-appropriate lever, 10 mg/kg Nuciferine also produces significant rate suppression as compared to vehicle control points (p<0.001).