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470-17-7

中文名稱 異土木香內(nèi)酯
英文名稱 Isoalantolactone
CAS 470-17-7
分子式 C15H20O2
MDL 編號(hào) MFCD00056777
分子量 232.32
MOL 文件 470-17-7.mol
更新日期 2024/12/23 10:26:08
470-17-7 結(jié)構(gòu)式 470-17-7 結(jié)構(gòu)式

基本信息

中文別名
異土木香內(nèi)酯
英文別名
(3ar,4as,8ar,9ar)-8a-methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one
ISOALANTOACTONE
ISOALANTOLACTONE
ISOHELENIN
11(13)-dien-12-oicacid,8-beta-hydroxy-eudesma-4(14gamma-lactone
methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-
Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-
(3aR)-3aα,4,4aα,5,6,7,8,8a,9,9aα-Decahydro-3,5-bismethylene-8aβ-methylnaphtho[2,3-b]furan-2(3H)-one
(3aR,4aα,9aα)-3a,4,4a,5,6,7,8,8a,9,9a-Decahydro-8aβ-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2(3H)-one
所屬類別
生物化工:中草藥成分

物理化學(xué)性質(zhì)

外觀性狀棱柱形結(jié)晶(稀乙醇),熔點(diǎn)112℃(115℃),溶于乙醇、乙醚、苯和氯仿,微溶于石油英,不溶于水。
熔點(diǎn)115℃
沸點(diǎn)364.9±42.0 °C(Predicted)
密度1.07±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度可溶于DMSO(高達(dá)50mg/ml)或乙醇(30mg/ml)
形態(tài)固體
顏色白色
穩(wěn)定性自購(gòu)買(mǎi)之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 或乙醇溶液可在 -20°C 下保存長(zhǎng)達(dá) 1 個(gè)月。
LogP3.420
CAS 數(shù)據(jù)庫(kù)470-17-7(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H317
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼40
安全說(shuō)明22-36
海關(guān)編碼29322090

應(yīng)用領(lǐng)域

用途1
異土木香內(nèi)酯具有驅(qū)蟲(chóng)、抗菌的作用。

常見(jiàn)問(wèn)題列表

生物活性

異土木香內(nèi)酯是一種烷化劑,用作細(xì)胞凋亡 (apoptosis) 誘導(dǎo)劑。

靶點(diǎn)

Human Endogenous Metabolite

體外研究

Isoalantolactone exhibits good cytotoxic activity against the K562 human leukaemia cell line (IC 50 =1.2 μM) . The cytotoxic effect of Isoalantolactone on pancreatic carcinoma is evaluated using PANC-1, BxPC3 and HPAC cell lines. Treatment with Isoalantolactone for 24 h inhibits PANC-1 cell growth in a dose-dependent manner. The inhibition rate is above 90% at 80 μM and the concentration to achieve 50% growth inhibition (IC 50 ) is 40 μM. A similar trend in loss of cell viability is observed in BxPC3 and HPAC cells on Isoalantolactone treatment with IC 50 values 43 and 48 μM respectively. Pretreatment with 3 mM N-Acetyl Cysteine (NAC), a specific ROS scavenger, restores the viability of cells indicating that Isoalantolactone exerts cytotoxic effect on cell viability through ROS generation.

體內(nèi)研究

The acute and chronic toxic effects of Isoalantolactone in CD1 mice are assessed by measuring the changes in body weight, blood biochemistry and histopathology of liver and kidneys in comparison with control groups. Isoalantolactone is well tolerated by mice and no mortality or any sign of pharmacotoxicity are found at a dose of 100 mg/kg during both experimental periods (7 & 30 days). Body weight gains and food consumption are comparable for control and treated mice during both experimental periods and there were no drug-related changes in histopathological and blood biochemistry parameters. The histopathological changes in liver and kidneys are assessed using hematoxylin and eosin staining and correlated with liver and renal function biomarkers. No obvious morphological changes are observed in liver and kidney structures of control and treatment groups. There is a slight increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level of treatment group at dose day 7 but this increase is not significantly different (P<0.05) from control group. A significant increase in total bilirubin (TBIL) concentration is found in treatment group (1.43±0.26 vs 0.76±0.12 in control, P<0.05) at dose day 7. Similarly the changes in renal function biomarkers are not significantly different (P<0.05) in the serum of control and treatment groups at dose day 7. The concentration of creatinine (Cr) slightly increases whereas concentration of blood urea nitrogen (BUN) slightly decreases in treatment group. The serum level of AST, ALT, TBIL and BUN slightly decreases when mice are injected with Isoalantolactone at a dose of 100 mg/kg for 30 days.

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