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440122-66-7

中文名稱 7-溴-2-(4-羥基苯基)苯并[D]惡唑-5-醇
英文名稱 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
CAS 440122-66-7
分子式 C13H8BrNO3
分子量 306.11
MOL 文件 440122-66-7.mol
更新日期 2024/12/26 13:39:40
440122-66-7 結(jié)構(gòu)式 440122-66-7 結(jié)構(gòu)式

基本信息

中文別名
化合物WAY 200070
7-溴-2-(4-羥基苯基)苯并[D]惡唑-5-醇
英文別名
WAY 200070
WAY200070
WAY 200070
7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
所屬類別
醫(yī)藥中間體:原料藥中間體

物理化學(xué)性質(zhì)

沸點463.6±35.0 °C(Predicted)
密度1.720±0.06 g/cm3(Predicted)
儲存條件Store at RT
溶解度二甲基亞砜:≥20mg/mL
酸度系數(shù)(pKa)7.26±0.40(Predicted)
形態(tài)固體
顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS06
警示詞危險
危險性描述H301-H319
危險品標(biāo)志T
危險類別碼25-36
安全說明26-45
危險品運輸編號UN 2811 6.1 / PGIII
WGK Germany3
危險等級6.1

常見問題列表

生物活性
WAY-200070是選擇性的雌激素受體激動劑,IC50值為2.3 nM。
靶點

IC50: 2.3 nM (ERRβ), 155 nM (ERRα)

體內(nèi)研究

Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.

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