1123231-07-1
中文名稱(chēng)
MAY-262611
英文名稱(chēng)
MAY-262611
CAS
1123231-07-1
分子式
C20H22N4
分子量
318.42
MOL 文件
1123231-07-1.mol
更新日期
2024/12/18 10:32:28
1123231-07-1 結(jié)構(gòu)式
基本信息
中文別名
WAY-262611游離態(tài)Β-聯(lián)蛋白激動(dòng)劑(WAY-262611)
1-[4-(2-萘基)-2-嘧啶基]-4-哌啶甲胺
英文別名
DKK1CS-1296
MAY-262611
WAY-262611
Wnt/β-catenin
WAY262611
WAY 262611
Human DKK1 Protein, His Tag
Recombinant Mouse Dkk-1 Protein, 8*His Tag
Recombinant Human DKK-1/DKK1 Protein, 8* His Tag
1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)544.8±42.0 °C(Predicted)
密度1.169±0.06 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
酸度系數(shù)(pKa)10.13±0.29(Predicted)
形態(tài)粉末
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
WAY-262611是 Wnt/β- 聯(lián)蛋白激動(dòng)劑，可增加骨形成速率，在 TCF- 熒光素酶測(cè)定實(shí)驗(yàn)中的 EC50 值為0.63 μM。WAY-262611 也是 Dkk1 的抑制劑。靶點(diǎn)
EC50: 0.63 μM (β-Catenin)
體外研究
WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
體內(nèi)研究
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β -catenin pathway and most likely through inhibition of Dkk-1.