347174-05-4
347174-05-4 結(jié)構(gòu)式
基本信息
鐵抑制劑-1
3-氨基-4-環(huán)己基氨基苯甲酸乙酯
3-氨基-4-(環(huán)己胺O)苯甲酸乙酯
Fer 1
Fer-1
3-amino-4-(cycL
Ferrostatin-1 (Fer-1)
Ferrostatin-1 (Fer-1) USP/EP/BP
Ethyl 3-amino-4-(cyclohexylamino)benzoate
3-Amino-4-cyclohexylaminobenzoic acid ethyl ester
Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester
FER-1
FER 1
FER1
FERROSTATIN-1
FERROSTATIN 1
FERROSTATIN1
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
| Target | Value |
|
Ferroptosis
(HT-1080 cells) | 60 nM(EC50) |
Ferrostatin-1(2 μM)作用于癌細(xì)胞，抑制Erastin誘導(dǎo)的Ferroptosis，F(xiàn)erroptosis是一種鐵依賴性的的非凋亡性細(xì)胞死亡，F(xiàn)errostatin-1作用于新生大鼠腦片，抑制 谷氨酸鹽誘導(dǎo)的細(xì)胞死亡。Ferrostatin-1是一種脂質(zhì)ROS清除劑，具有N-環(huán)己基部分，作為生物膜內(nèi)親脂錨。Ferrostatin-1不抑制細(xì)胞外信號(hào)調(diào)節(jié)激酶（ERK）磷酸化或HT-1080細(xì)胞增殖停滯，說明Ferrostatin-1不抑制MEK/ERK通路，螯合鐵，或抑制蛋白合成。Ferrostatin-1抑制Erastin誘導(dǎo)的胞漿和脂質(zhì)ROS積累。的無細(xì)胞條件下，F(xiàn)errostatin-1容易氧化穩(wěn)定自由基2,2-二苯基-1-苦肼基（DPPH）。
Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction .
Ferrostatin-1 (0.8?mg/kg; tail vein injection) effectively alleviated LPS-induced induced acute lung injury (ALI).
Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis.
| Animal Model: | Male C57BL/6 mice (LPS-induced ALI) |
| Dosage: | 0.8?mg/kg |
| Administration: | Tail vein injection |
| Result: | Exerted therapeutic action against LPS-induced ALI. |
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2021/03/30 | S7243 | Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) | 347174-05-4 | 5mg | 1193.05元 |
| 2021/03/30 | S7243 | Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) | 347174-05-4 | 10mM(1mL in DMSO) | 3252.11元 |
| 2021/03/30 | S7243 | Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) | 347174-05-4 | 25mg | 3677.84元 |