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33627-41-7

中文名稱 旋覆花內(nèi)酯
英文名稱 inulicin
CAS 33627-41-7
分子式 C17H24O5
分子量 308.37
MOL 文件 33627-41-7.mol
更新日期 2024/11/05 13:10:54
33627-41-7 結(jié)構(gòu)式 33627-41-7 結(jié)構(gòu)式

基本信息

中文別名
旋覆花素
旋復(fù)花內(nèi)酯
旋覆花內(nèi)酯
旋覆花次內(nèi)酯
乙酰旋覆花內(nèi)酯
1-O-乙?;蠡ㄐ不▋?nèi)酯
英文別名
inulicin
Britannilactone
inulicin USP/EP/BP
Inulicin(1-O-acetyl Britannilactone)
1-O-Acetylbritannilactone (Inulicin)
6-(3-acetoxy-propyl)-4-hydroxy-5,7-dimethyl-3-methylene-3,3a,4,5,8,8a-hexahydro-cyclohepta[b]furan-2-one
(3aS)-6-(3-Acetoxypropyl)-3,3aα,4,5,8,8aα-hexahydro-4α-hydroxy-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one
(3aS)-3,3aα,4,5,8,8aα-Hexahydro-4α-hydroxy-6-(3-acetoxypropyl)-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one
(3aS,4S,7aR)-5-[(1S)-4-(Acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-2(3H)-benzofuranone
2(3H)-Benzofuranone,5-[(1S)-4-(acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-,(3aS,4S,7aR)-
所屬類別
生物化工:中草藥成分

物理化學(xué)性質(zhì)

熔點124.0-126.1 °C
沸點481.7±45.0 °C(Predicted)
密度1.16
儲存條件4°C, protect from light
溶解度可溶于DMSO
酸度系數(shù)(pKa)13.71±0.60(Predicted)
形態(tài)固體
顏色White to off-white
旋覆花內(nèi)酯價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/08/19HY-N0896旋覆花內(nèi)酯
Inulicin
33627-41-71mg430元
2024/08/19HY-N0896旋覆花內(nèi)酯
Inulicin
33627-41-75mg990元
2024/08/19HY-N0896旋覆花內(nèi)酯
Inulicin
33627-41-710 mM * 1 mLin DMSO1089元

常見問題列表

生物活性
Inulicin (1-O-Acetylbritannilactone) 是從 Inula Britannica L 分離的一種活性化合物。Inulicin (1-O-Acetylbritannilactone) 抑制 VEGF 介導(dǎo)的 Src 和 FAK 活化。Inulicin (1-O-Acetylbritannilactone) 還抑制 LPS 誘導(dǎo)的 PGE2 產(chǎn)生和 COX-2 表達(dá),以及抑制 NF-κB 活化和易位。
靶點

NF-κB

COX-2

體外研究

Inulicin (1-O-Acetylbritannilactone) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Inulicin dose-dependently inhibits vascular endothelial growth factor (VEGF)-induced proliferation, migration, and capillary structure formation of cultured human umbilical vascular endothelial cells (HUVECs). Treatment of A549 NSCLC cells with Inulicin results in cell growth inhibition and Src-FAK in-activation. The potential effect of Inulicin is tested ton Src and FAK phosphorylation in A549 lung cancer cells. Significant high levels of Src and FAK phosphorylations are noticed a in A549 cells, which are both inhibited by treatment of Inulicin (5 μM and 10 μM). Src and FAK are both important for cancer cell proliferation. Thus, A549 cell growth, tested by MTT assay and clonogenicity assay,is remarkably inhibited by corresponding Inulicin treatment. The anti-A549 cell growth activity of Inulicin is again dose-dependent. Inulicin (1-O-Acetylbritannilactone) isolated from Inula britannica-F. , inhibits inflammatory responses in vascular smooth muscle cells (VSMCs). Inulicin (5, 10, 20 μM) has several concentration dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE 2 production and COX-2 expression, and blockade of NF-κB activation and translocation. In addition, Inulicin directly inhibits the binding of active NF-κB to specific DNA cis-element.

體內(nèi)研究

Administration of a single dose of Inulicin (1-O-Acetylbritannilactone; 12 mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice. In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. To investigate the potential activity of Inulicin in vivo, a nude mice xenograft model is applied. A single dose of Inulicin (12 mg/kg/day, i.p.) dramatically inhibits the growth of A549 xenografts in nude mice. Further, the weights of Inulicin-treated tumors are remarkably lighter than that of vehicle-treated tumors. Notably, Inulicin administration does not affect mice body weights.

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