| Identification | Back Directory | [Name]
inulicin | [CAS]
33627-41-7 | [Synonyms]
inulicin
Britannilactone
inulicin USP/EP/BP
Inulicin（1-O-acetyl Britannilactone）
1-O-Acetylbritannilactone (Inulicin)
6-(3-acetoxy-propyl)-4-hydroxy-5,7-dimethyl-3-methylene-3,3a,4,5,8,8a-hexahydro-cyclohepta[b]furan-2-one
(3aS)-3,3aα,4,5,8,8aα-Hexahydro-4α-hydroxy-6-(3-acetoxypropyl)-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one
(3aS)-6-(3-Acetoxypropyl)-3,3aα,4,5,8,8aα-hexahydro-4α-hydroxy-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one
(3aS,4S,7aR)-5-[(1S)-4-(Acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-2(3H)-benzofuranone
2(3H)-Benzofuranone,5-[(1S)-4-(acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-,(3aS,4S,7aR)- | [Molecular Formula]
C17H24O5 | [MOL File]
33627-41-7.mol | [Molecular Weight]
308.37 |
| Chemical Properties | Back Directory | [Melting point ]
124.0-126.1 °C | [Boiling point ]
481.7±45.0 °C(Predicted) | [density ]
1.16 | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
13.71±0.60(Predicted) | [color ]
White to off-white | [biological source]
plant |
| Hazard Information | Back Directory | [Uses]
Inulicin is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research. | [Biological Activity]
Inulicin (1-O-Acetylbritannilactone) is an active compound isolated from Inula Britannica L. It inhibits VEGF-mediated activation of Src and FAK. It also inhibits LPS-induced PGE2 production and COX-2 expression, as well as NF-κB activation and translocation. | [in vivo]
Administration of a single dose of Inulicin (1-O-Acetylbritannilactone; 12 mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice. In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. To investigate the potential activity of Inulicin in vivo, a nude mice xenograft model is applied. | [target]
| [storage]
4°C, protect from light |
|
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