30964-13-7
基本信息
洋薊酸
菜薊素
朝薊素
朝鮮薊酸 1,5
朝鮮薊酸1,3
1,3-二咖啡??鼘幩?/span>
1,5-DICAFFEOYLQUINIC ACID
CINARAN
CINARINE
CYNARIN
CYNARIN(ARTICHOKE)
CYNARIN(ECHINACEA)
CYNARIN(ARTICHOKE)(1,5-DICAFFEOYLQUINIC ACID)(P)
CYNARIN(ECHINACEA)(1,3-DICAFFEOYLQUINIC ACID)(AHP)
(1R,3R,4S,5R)-1,3-Bis[[3-(3,4-dihydroxyphenyl)propenoyl]oxy]-4,5-dihydroxycyclohexanecarboxylic acid
(1R)-1,5α-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-3β,4α-dihydroxycyclohexane-1β-carboxylic acid
(1R)-1β,3β-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-4β,5α-dihydroxycyclohexanecarboxylic acid
1,3-O-Dicaffeoylquinic acid
1β,3β-Bis[3-(3,4-dihydroxyphenyl)propenoyloxy]-4β,5α-dihydroxycyclohexanecarboxylic acid
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
常見問題列表
Target | Value |
CD28 - CD80 interaction
() | |
Nrf2
() | |
GSH
() | |
ROS
() |
Cynarin inhibits taste receptors, making water to be sweet. It has been shown to have some pharmacological properties including hypocholesterolemic, hepatoprotective, antiviral, antibacterial, and antihistamic effects. Cynarin has marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities. Cynarin demonstrates 87.72% inhibition of linoleic acid lipid peroxidation at 30 mg/mL concentration. Cynarin exhibits effective DMPD + , ABTS + , O 2 - , DPPH 1 , and H 2 O 2 scavenging effects, reducing capabilities and Fe 2+ chelating effects. IC 50 and K i of cynarin for acetylcholinesterase enzyme inhibition are 243.67nM and 39.34±13.88 nM, respectively. Cynarin is a potential immunosuppressant that blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin blocks about 87% of the CD28-dependent "signal 2" pathway of T-cell activation under the condition of one to one ratio of T-cell and B-cell. Cynarin binds to the "G-pocket" of CD28 and thus interrupts the site of interaction between CD28 and CD80.