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26993-30-6

中文名稱 D-蘇式-鞘胺醇-1-磷酸
英文名稱 D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
CAS 26993-30-6
分子式 C18H38NO5P
MDL 編號(hào) MFCD00274457
分子量 379.47
MOL 文件 26993-30-6.mol
更新日期 2024/01/22 13:00:57
26993-30-6 結(jié)構(gòu)式 26993-30-6 結(jié)構(gòu)式

基本信息

中文別名
D-蘇式-鞘胺醇-1-磷酸
英文別名
1-SPP
D-ERYTHRO-DIHYDROSPHINGOSINE-1-PHOSPHATE
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
(E)-D-ERYTHRO-2-AMINO-1-(DIHYDROGENPHOSPHATE)-4-OCTADECENE-1,3-DIOL
S1P
SPA
SPHINGOSINE-1-PHOSPHATE
SPHINGOSINE-1-PHOSPHATE, D-ERYTHRO
SPHINGOSINE-1-PHOSPHORIC ACID
SPHINGOSINE-1-PO4
SPN-1-P
SHINGOSINE-1-PHOSPHATE \ EDG-1 RECEPTOR
(2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid
1,3-Octadecanediol, 2-amino-, 1-(dihydrogen phosphate), D-erythro- (8C I)
所屬類別
生物化工:生化試劑

物理化學(xué)性質(zhì)

熔點(diǎn)179-189°C
沸點(diǎn)548.8±60.0 °C(Predicted)
密度1.094±0.06 g/cm3(Predicted)
RTECS號(hào)RG2260500
儲(chǔ)存條件−20°C
儲(chǔ)存條件-20°C
溶解度methanol: THF: water (6:3:1): >0.5 mg/mL
溶解度可溶于甲醇:四氫呋喃:水(6:3:1):>0.5 mg/mL
酸度系數(shù)(pKa)1.76±0.10(Predicted)
形態(tài)waxy solid
顏色yellow
敏感性感光
穩(wěn)定性對(duì)水分、溫度敏感;有吸濕性
CAS 數(shù)據(jù)庫26993-30-6(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
危險(xiǎn)類別碼R36/37/38
安全說明26-36
安全說明S26-S36
WGK Germany3
WGK Germany3
海關(guān)編碼29225090
DEA Controlled SubstancesCSCN: 1635
CAS SCH: IV
NARC: N

知名試劑公司產(chǎn)品信息

常見問題列表

生物活性
Sphingosine-1-phosphate (S1P) 是 S1P1-5 受體 (S1P1-5 receptors) 的激動(dòng)劑和 GPR3、GPR6、GPR12 的配體。Sphingosine-1-phosphate 是細(xì)胞內(nèi)的第二信使,動(dòng)員 Ca2+ 作為 G 蛋白偶聯(lián)受體的細(xì)胞外配體。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂質(zhì)介質(zhì)。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

S1P (1 μM) induces a significant Ca 2+ releases in HEK293 cells under serum starvation conditions (1% FCS).In a functional Ca 2+ assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca 2+ release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca 2+ release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells. In a functional Ca 2+ assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC 50 values for gpr3 (EC 50 =29 nM), gpr6 (EC 50 =15 nM) and gpr12 (EC 50 =24 nM), rat gpr3 (EC 50 =68 nM),respectively in HEK293 cells. S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1?and G qi5 , which allows for phospholipase C stimulation by G i proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2?and S1P3?receptors (EC 50 s = 8 and 11 nM, respectively).

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