26993-30-6
基本信息
D-ERYTHRO-DIHYDROSPHINGOSINE-1-PHOSPHATE
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
(E)-D-ERYTHRO-2-AMINO-1-(DIHYDROGENPHOSPHATE)-4-OCTADECENE-1,3-DIOL
S1P
SPA
SPHINGOSINE-1-PHOSPHATE
SPHINGOSINE-1-PHOSPHATE, D-ERYTHRO
SPHINGOSINE-1-PHOSPHORIC ACID
SPHINGOSINE-1-PO4
SPN-1-P
SHINGOSINE-1-PHOSPHATE \ EDG-1 RECEPTOR
(2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid
1,3-Octadecanediol, 2-amino-, 1-(dihydrogen phosphate), D-erythro- (8C I)
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
知名試劑公司產(chǎn)品信息
常見(jiàn)問(wèn)題列表
Human Endogenous Metabolite
|
S1P (1 μM) induces a significant Ca 2+ releases in HEK293 cells under serum starvation conditions (1% FCS).In a functional Ca 2+ assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca 2+ release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca 2+ release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells. In a functional Ca 2+ assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC 50 values for gpr3 (EC 50 =29 nM), gpr6 (EC 50 =15 nM) and gpr12 (EC 50 =24 nM), rat gpr3 (EC 50 =68 nM),respectively in HEK293 cells. S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1?and G qi5 , which allows for phospholipase C stimulation by G i proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2?and S1P3?receptors (EC 50 s = 8 and 11 nM, respectively).