206184-49-8
基本信息
替諾福韋(含水)
替諾福韋一水合物
替諾福韋單水合物
替諾福韋一水化合物
泰諾福韋 USP標(biāo)準(zhǔn)品
9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤
9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(含水)
9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物)
9-(R)-2-(磷酰甲氧基)丙基腺嘌呤(R-PMPA)
Unii-99yxe507il
PMPA Monohydrate
Tenofovir (15 mg)
Tenofovir (hydrate)
R-PMPA of Tenofovir
Tenofovir Monohydrate
(R)-9-(2-phosphonylmethoxy propyl)adenine(R-PMPA)
9-[(R)-2-(Phosphonomethoxy)propyl]adenine 1-hydrate
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
常見問題列表
Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC 50 values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage. Tenofovir and M48U1 formulated in 0.25% HEC each inhibits the replication of both R5-tropic HIV-1 BaL and X4-tropic HIV-1 IIIb in activated PBMCs, and inhibits several laboratory strains and patient-derived HIV-1 isolates. The combined formulation of M48U1 and tenofovir in 0.25% HEC exhibits synergistic antiretroviral activity against infection with R5-tropic HIV-1 BaL , and is not toxic to PBMCs.
Tenofovir Disoproxil Fumarate (20, 50, 140, or 300?mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300?mg/kg) significantly reduces HIV transmission in BLT mice. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection.
報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
2024/11/08 | HY-13910A | 9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物) Tenofovir hydrate | 206184-49-8 | 5mg | 465元 |
2024/11/08 | HY-13910A | 9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物) Tenofovir hydrate | 206184-49-8 | 10 mM * 1 mLin DMSO | 512元 |
2024/11/08 | HY-13910A | 9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物) Tenofovir hydrate | 206184-49-8 | 10mg | 700元 |