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206184-49-8

中文名稱 9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物)
英文名稱 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
CAS 206184-49-8
分子式 C9H16N5O5P
分子量 305.23
MOL 文件 206184-49-8.mol
更新日期 2025/01/26 14:41:36
206184-49-8 結(jié)構(gòu)式 206184-49-8 結(jié)構(gòu)式

基本信息

中文別名
替諾福韋一水物
替諾福韋(含水)
替諾福韋一水合物
替諾福韋單水合物
替諾福韋一水化合物
泰諾福韋 USP標(biāo)準(zhǔn)品
9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤
9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(含水)
9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物)
9-(R)-2-(磷酰甲氧基)丙基腺嘌呤(R-PMPA)
英文別名
Tenofovir(H2O)
Unii-99yxe507il
PMPA Monohydrate
Tenofovir (15 mg)
Tenofovir (hydrate)
R-PMPA of Tenofovir
Tenofovir Monohydrate
(R)-9-(2-phosphonylmethoxy propyl)adenine(R-PMPA)
9-[(R)-2-(Phosphonomethoxy)propyl]adenine 1-hydrate
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)270-274oC
儲(chǔ)存條件2-8°C
溶解度可溶于酸性水溶液(少許)、DMSO(少許)
形態(tài)固體
顏色白色至灰白色
穩(wěn)定性吸濕性

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H301
海關(guān)編碼2933599550

常見問題列表

應(yīng)用
TDF 用于有病毒復(fù)制證據(jù)以及和血清轉(zhuǎn)氨酶( ALT 或AST) 持續(xù)升高或肝活動(dòng)性病變證據(jù)的CHB 成年患者。包括HBeAg 陽性或HBeAg 陰性的代償期CHB 的成年患者。
生物活性
Tenofovir hydrate (GS 1278 hydrate) 是一種核苷酸逆轉(zhuǎn)錄酶 (nucleotide reverse transcriptase) 抑制劑,可用于 HIV和慢性乙型肝炎 (Hepatitis B; HBV) 的研究。
體外研究

Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC 50 values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage. Tenofovir and M48U1 formulated in 0.25% HEC each inhibits the replication of both R5-tropic HIV-1 BaL and X4-tropic HIV-1 IIIb in activated PBMCs, and inhibits several laboratory strains and patient-derived HIV-1 isolates. The combined formulation of M48U1 and tenofovir in 0.25% HEC exhibits synergistic antiretroviral activity against infection with R5-tropic HIV-1 BaL , and is not toxic to PBMCs.

體內(nèi)研究

Tenofovir Disoproxil Fumarate (20, 50, 140, or 300?mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300?mg/kg) significantly reduces HIV transmission in BLT mice. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection.

9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物)價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08HY-13910A9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物)
Tenofovir hydrate
206184-49-85mg465元
2024/11/08HY-13910A9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物)
Tenofovir hydrate
206184-49-810 mM * 1 mLin DMSO512元
2024/11/08HY-13910A9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物)
Tenofovir hydrate
206184-49-810mg700元
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