19767-45-4
中文名稱
美司那
英文名稱
Mesna
CAS
19767-45-4
EINECS 編號(hào)
243-285-9
分子式
C2H5NaO3S2
MDL 編號(hào)
MFCD00007535
分子量
164.18
MOL 文件
19767-45-4.mol
更新日期
2025/01/10 10:15:12
19767-45-4 結(jié)構(gòu)式
基本信息
中文別名
2-巰乙基磺酸鈉鹽美司那
巰乙基磺酸鈉
2-巰基乙磺酸鈉
巰乙磺酸鈉
2-巰基乙烷磺酸鈉
美司鈉
美法倫
英文別名
2-MERCAPTOETHANESULFONIC ACID SODIUM2-MERCAPTOETHANESULFONIC ACID SODIUM SALT
2-MERCAPTOETHANESULPHONIC ACID SODIUM SALT
COENZYME M
COENZYME M SODIUM SALT
HS-COM NA
MERCAPTOETHANESULFONIC ACID SODIUM SALT
MESNA
MESNA SODIUM SALT
mesnaum
MESNEX
SODIUM 2-MERCAPTOETHANESULFONATE
2-mercaptoethanesulfonic
2-mercaptoethanesulfonicacidmonosodiumsalt
2-mercapto-ethanesulfonicacimonosodiumsalt
mesnum
mistabron
mitexan
mucofluid
uromitexan
所屬類別
醫(yī)藥中間體：原料藥中間體物理化學(xué)性質(zhì)
外觀性狀美司那(19767-45-4)為白色結(jié)晶
熔點(diǎn)>240°C dec.
儲(chǔ)存條件-20°C 冰箱，在惰性氣氛下穩(wěn)定
溶解度Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane
形態(tài)neat
顏色白色至灰白色
水溶解性Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml).
Merck5909
BRN3657828
穩(wěn)定性穩(wěn)定的。與強(qiáng)氧化劑不相容。
CAS 數(shù)據(jù)庫19767-45-4(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼R36/37/38
安全說明S26-S36
WGK Germany2
RTECS號(hào)KI7968000
海關(guān)編碼29309090
毒性LD50 in male, female mice, male, female rats (mg/kg): 1887, 2048, 2098, 1683 i.v.; 2005, 2098, 1529, 1251 i.p.; 6102, >7200, 4440, 4679 orally (Brock)
美司鈉價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/11 | XW197674542 | 2-巰基乙烷磺酸鈉 sodium 2-mercaptoethane sulfonate;2-mercaptoethane sulfonic acid sodium salt;2-mercaptoethane sulfonic acid na-salt;hs-comna;coenzyme m sodium salt;mesnex;mistabron;mistabronco;mucofluid;uromifexan;mesna(mesna);ucb-3983;d-7093 | 19767-45-4 | 25G | 626元 |
| 2024/11/11 | XW197674541 | 2-巰基乙烷磺酸鈉 sodium 2-mercaptoethane sulfonate;2-mercaptoethane sulfonic acid sodium salt;2-mercaptoethane sulfonic acid na-salt;hs-comna;coenzyme m sodium salt;mesnex;mistabron;mistabronco;mucofluid;uromifexan;mesna(mesna);ucb-3983;d-7093 | 19767-45-4 | 5G | 288元 |
| 2024/11/08 | 44315 | 美司那 2-Mercaptoethanesulfonic acid sodium salt, 98%, analytical standard, Thermo Scientific Chemicals | 19767-45-4 | 5g | 652元 |
常見問題列表
生物活性
Mesna 是巰基化合物，用于降低與某些化療劑相關(guān)的出血性膀胱炎的發(fā)病率。體外研究
Mesna (1-1000 μM) reduces H 2 O 2 , HOCl and OH? concentrations in a dose-dependent manner, with an IC 50 of 32, 21, and 305 μM, respectively in cell-free experiments.
體內(nèi)研究
Mesna (150 mg/kg; a single i.p.) protects the rat brain against traumatic injury.
Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats.
| Animal Model: | Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI) |
| Dosage: | 150 mg/kg |
| Administration: | A single i.p. |
| Result: |
Decreased tissue malondialdehyde levels.
Increased the activity of glutathione peroxidase and superoxide dismutase. Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase. Protected the brain tissues well from injury. |