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13392-18-2

中文名稱(chēng) 非諾特羅
英文名稱(chēng) Fenoterol
CAS 13392-18-2
分子式 C17H21NO4
MDL 編號(hào) MFCD00242675
分子量 303.35
MOL 文件 13392-18-2.mol
更新日期 2024/12/17 09:24:27
13392-18-2 結(jié)構(gòu)式 13392-18-2 結(jié)構(gòu)式

基本信息

中文別名
5-[1-羥基-2-[[2-(4-羥基苯基)-1-甲基乙基]氨基]乙基]-1,3-苯二酚
非諾特羅
英文別名
1-(3,5-dihydroxyphenyl)-1-hydroxy-2-[(4-hydroxyphenyl)isopropylamino]ethane
5-[1-hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-1,3-benzenediol
AURORA KA-7877
FENOTEROL
1-(p-hydroxyphenyl)-2-((beta-hydroxy-beta-(3’,5’-dihydroxyphenyl))ethyl)amin
1,3-benzenediol,5-(1-hydroxy-2-((2-(4-hydroxyphenyl)-1-methylethyl)amino)eth
3,5-dihydroxy-alpha-(((p-hydroxy-alpha-methylphenethyl)amino)methyl)benzyla
benzylalcohol,3,5-dihydroxy-alpha-(((p-hydroxy-alpha-methylphenethyl)amino)me
lcohol
opropane
1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-[1-(4-hydroxyphenyl)isopropyl]aminoethane
1-(3,5-Dihydroxyphenyl)-2-(p-hydroxy-α-methylphenethylamino)ethanol
1-(3,5-Dihydroxyphenyl)-2-[[1-(4-hydroxybenzyl)ethyl]amino]ethanol
1,3-Benzenediol, 5-[1-hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-
3,5-Dihydroxy-α-[p-hydroxy-α-methylphenethylamino]methylbenzyl alcohol
Benzyl alcohol, 3,5-dihydroxy-α-[[(p-hydroxy-α-methylphenethyl)amino]methyl]- (8CI)
Phenoterol
Th 1165
3,5-Dihydroxy-α-[[(4-hydroxy-α-methylphenethyl)amino]methyl]benzyl alcohol
所屬類(lèi)別
原料藥:平喘藥

物理化學(xué)性質(zhì)

熔點(diǎn)181-183°C
沸點(diǎn)566.0±45.0 °C(Predicted)
密度1.289±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
酸度系數(shù)(pKa)pKa 8.5 (Uncertain);10.0 (Uncertain)
形態(tài)Solid
顏色Light brown to brown
CAS 數(shù)據(jù)庫(kù)13392-18-2(CAS DataBase Reference)

安全數(shù)據(jù)

警示詞警告
危險(xiǎn)性描述H332-H302

常見(jiàn)問(wèn)題列表

生物活性
Fenoterol (Phenoterol) 是β2 adrenoreceptor激動(dòng)劑,具有支氣管擴(kuò)張活性。
靶點(diǎn)
TargetValue
β2 adrenoreceptor
()
體外研究

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.

Western Blot Analysis

Cell Line: THP-1 cells stimulated with AICAR
Concentration: 1 μM
Incubation Time: Pre-incubated 30 minutes
Result: Significantly downregulated the elevated phosphorylation levels of AMPK.
體內(nèi)研究

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.

Animal Model: Male C57BL/6J mice (6 weeks old) with neuropathy
Dosage: 0.7 mg/kg
Administration: Intraperitoneal injection; twice a day; for 3 weeks
Result: Alleviated neuropathic allodynia during chronic treatment.
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