| Identification | More | [Name]
Phenformin hydrochloride | [CAS]
834-28-6 | [Synonyms]
1-phenethylbiguanide hydrochloride
PHENETHYLBIGUANIDE HYDROCHLORIDE
PHENFORMIN HCL
PHENFORMIN HYDROCHLORIDE
1-fenetilbiguanidecloridrato
1-phenethyl-biguanidhydrochloride
1-phenethyl-biguanidmonohydrochloride
1-phenylaethylbiguanidhydrochlorid
dbi-td
meltrol
n-(2-phenylethyl)-imidodicarbonimidicdiamidmonohydrochloride
n(sup1)-beta-phenethylbiguanidehydrochloride
n’-beta-phenethylbiguanidehydrochloride
n-beta-phenylethylbiguanidehydrochloride
phenforminhclno.9113
phenoforminehydrochloride
usafvi-6
Phenformine HCL
PHENFORMINI HYDROCHLORIDE
Insora | [EINECS(EC#)]
212-637-3 | [Molecular Formula]
C10H16ClN5 | [MDL Number]
MFCD00035039 | [Molecular Weight]
241.72 | [MOL File]
834-28-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
175-178°C | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
neat | [color ]
White to Off-White | [Water Solubility ]
>=10 g/100 mL at 21 ºC | [Usage]
It is an anti-diabetic drug from the biguanide class | [CAS DataBase Reference]
834-28-6(CAS DataBase Reference) | [EPA Substance Registry System]
834-28-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
DU2200000
| [HS Code ]
29252900 | [Toxicity]
LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske) |
| Hazard Information | Back Directory | [General Description]
White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis. | [Reactivity Profile]
PHENFORMIN HYDROCHLORIDE(834-28-6) gives weakly acidic aqueous solutions. May react with strong oxidizing agents. | [Air & Water Reactions]
Water soluble. | [Fire Hazard]
Flash point data for this chemical are not available; however, PHENFORMIN HYDROCHLORIDE is probably combustible. | [Description]
Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus.1 In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling.2,3 Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently.1 Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.4 | [Chemical Properties]
White Crystalline Solid | [Uses]
erectile dysfunction therapy | [Uses]
It is an anti-diabetic drug from the biguanide class | [Brand name]
DBI (Ciba-Geigy). | [Safety Profile]
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx. | [storage]
Store at -20°C |
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