| Identification | More | [Name]
Phenazopyridine hydrochloride | [CAS]
136-40-3 | [Synonyms]
2,6-DIAMINO-3-[PHENYLAZO]PYRIDINE HYDROCHLORIDE
2,6-DIAMINO-3-(PHENYLAZO)PYRIDINE MONOHYDROCHLORIDE
3-BENZENEAZO-2,6-DIAMINOPYRIDINE MONOHYDROCHLORIDE
3-PHENYLAZO-2,6-DIAMINOPYRIDINE HYDROCHLORIDE
3-PHENYLAZO-2,6-DIAMINOPYRIDINE MONOHYDROCHLORIDE
3-(PHENYLAZO)-2,6-PYRIDINEDIAMINE, MONOHYDROCHLORIDE
BISTERIL
MALLOPHENE
PHENAZODINE
PHENAZOPYRIDINE HCL
PHENAZOPYRIDINE HYDROCHLORIDE
PHENYLAZODIAMINOPYRIDINE HYDROCHLORIDE
PYRIDACIL
PYRIDIATE
PYRIDIUM
URODINE
2,6-diamino-3-(phenylazo)-pyridinmonohydrochloride
3-(phenylazo)-2,6-pyridinediamine,hydrochloride
6-pyridinediamine,3-(phenylazo)-monohydrochloride
azodyne | [EINECS(EC#)]
205-243-8 | [Molecular Formula]
C11H10ClN3 | [MDL Number]
MFCD00035347 | [Molecular Weight]
219.67 | [MOL File]
136-40-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Brick-Red Crystals | [Melting point ]
139°C | [Boiling point ]
394.6°C (rough estimate) | [density ]
1.2645 (rough estimate) | [refractive index ]
1.6110 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
Liquid | [color ]
Clear to hazy colorless to yellow | [Water Solubility ]
0.01-0.1 g/100 mL at 20 ºC | [Usage]
Used as an analgesic (urinary tract) | [Merck ]
7210 | [Stability:]
Light Sensitive | [InChIKey]
QQBPIHBUCMDKFG-GEEYTBSJSA-N | [CAS DataBase Reference]
136-40-3(CAS DataBase Reference) | [IARC]
2B (Vol. 24, Sup 7) 1987 | [EPA Substance Registry System]
136-40-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,C | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
2811 | [WGK Germany ]
3 | [RTECS ]
US7875000 | [HS Code ]
29333990 | [Safety Profile]
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: somnolence, cyanosis, dlarrhea, nausea or vomiting, anuria or decreased urine volume, normocytic anemia, methemoglobinemiacarboxyhemoglobinemia, dehydration, changes in blood sodium levels. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl | [Toxicity]
LD50 orally in rats: 403 mg/kg (Becker, Swift) |
| Hazard Information | Back Directory | [General Description]
Brick-red microcrystals with a slight violet luster or a purple powder. Aqueous solutions are yellow to brick-red and slightly acidic; they may be stabilized by the addition of 10% glucose. Slightly bitter taste. | [Reactivity Profile]
PHENAZOPYRIDINE HYDROCHLORIDE is an azo compound. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. | [Air & Water Reactions]
Dust can be explosive when suspended in air at specific concentrations. PHENAZOPYRIDINE HYDROCHLORIDE(136-40-3) may be sensitive to air and light. . Very slightly water soluble. | [Fire Hazard]
Flash point data for this chemical are not available. PHENAZOPYRIDINE HYDROCHLORIDE is probably combustible. | [Description]
Phenazopyridine is an azo dye with analgesic properties.1 It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg.2 Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections. | [Chemical Properties]
Brick-Red Crystals | [Originator]
Phenazopyridine
,AroKor Holdings Inc. | [Uses]
An azo dye used in treatment of urinary tract infections. Used as an analgesic (urinary tract). | [Uses]
anticonvulsant, antieleptic | [Uses]
Phenazopyridine hydrochloride has been used for 50 years as an analgesic drug either alone or in combination with other drugs to reduce pain associated with urinary tract infection. An azo dye used in urinary tract infections. Also used as a local anesthetic. Exposure to phenazopyridine hydrochloride occurs during manufacture and formulation.
| [Uses]
therapeutic for urinary tract infections | [Definition]
ChEBI: A hydrochloride obtained by combining phenazopyridine with one equivalent of hydrochloric acid. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disord
rs) and potential carcinogenicity. | [Manufacturing Process]
Phenyldiazene chloride reacted with 2,6-diaminopyridine and in the result 2,6diamino-3-(phenylazo)pyridine was obtained.
In practice it is usually used as monohydrochloride. | [Brand name]
Pyridium (Parke-Davis). | [Therapeutic Function]
Urinary analgesic, Antiseptic, Diagnostic aid | [Clinical Use]
Phenazopyridine hydrochloride, 2,6-diamino-3-(phenylazopyridinehydrochloride (Pyridium), is a brick-red, finecrystalline powder. It is slightly soluble in alcohol, in chloroform,and in water.Phenazopyridine hydrochloride was formerly used asa urinary antiseptic. Although it is active in vitro againststaphylococci, streptococci, gonococci, and E. coli, it has nouseful antibacterial activity in the urine. Thus, its presentutility lies in its local analgesic effect on the mucosa of theurinary tract.
Usually, phenazopyridine is given in combination withurinary antiseptics. For example, it is available as Azo-Gantrisin, a fixed-dose combination with the sulfonamide antibacterialsulfisoxazole, and as Urobiotic, a combination withthe antibiotic oxytetracycline and the sulfonamide sulfamethizole. The drug is rapidly excreted in the urine, towhich it gives an orange-red color. Stains in fabrics may beremoved by soaking in a 0.25% solution of sodium dithionite. | [Carcinogenicity]
Phenazopyridine hydrochloride is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity fromstudies in experimental animals. | [storage]
Store at 2-8°C |
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