| Identification | More | [Name]
Sitagliptin phosphate monohydrate | [CAS]
654671-77-9 | [Synonyms]
SITAGLIPTIN PHOSPHATE
7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate
Sitagliptin phosphate monohydrate
Sitagliptin phosphate for research | [EINECS(EC#)]
682-492-2 | [Molecular Formula]
C16H20F6N5O6P | [MDL Number]
MFCD10001393 | [Molecular Weight]
523.324 | [MOL File]
654671-77-9.mol |
| Chemical Properties | Back Directory | [Fp ]
274.3℃ | [storage temp. ]
2-8°C | [solubility ]
≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥30.6 mg/mL in H2O with ultrasonic | [form ]
solid | [color ]
White to off-white | [InChIKey]
IQFYVLUXQXSJJN-OVMXBOEKNA-N | [SMILES]
P(O)(O)(O)=O.C(C1=NN=C2CN(C(=O)C[C@H](N)CC3C=C(F)C(F)=CC=3F)CCN12)(F)(F)F |&1:15,r| | [CAS DataBase Reference]
654671-77-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline | [Uses]
antimuscarinic | [Biological Activity]
sitagliptin phosphate monohydrate is the phosphate salt of its active component, sitagliptin, with one molecule of water. sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (dpp-4), an enzyme catalyzing the cleavage of peptides with an n-terminal alanine or proline amino acid residue, that selectively inhibits dpp-4 with 50% inhibition concentration ic50 value of 18 nm and shows no affinity towards other ddp enzymes (such as ddp-8 and ddp-9). the inhibition of dpp4 by sitagliptin has been found to be mediated by increasing levels of two dpp-4 substrates, including glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip). sitagliptin is currently being investigated in the treatment of type ii diabetes.gallwitz b. review of sitagliptin phosphate: a novel treatment for type 2 diabetes. vasc health risk manag. 2007;3(2):203-10. | [target]
DPP-4 | [storage]
Store at -20°C |
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