| Identification | More | [Name]
Trisodium phosphate | [CAS]
7601-54-9 | [Synonyms]
BUFFER SOLUTION, PH 2.5
BUFFER SOLUTION, PH 3.0
BUFFER SOLUTION, PH 6.5
BUFFER SOLUTION, PH 7.0
BUFFER SOLUTION, PH 7.5
BUFFER SOLUTION, PH 8.0
BUFFER SOLUTION, PH 8.5
BUFFER SOLUTION, PH 9.0
BUFFER SOLUTION, PH 9.5
DPD PHOSPHATE BUFFER
MILLONIG'S PHOSPHATE BUFFER
SODIUM PHOSPHATE
SODIUM PHOSPHATE BUFFER
SODIUM PHOSPHATE, TRIBASIC
TRI-SODIUM ORTHOPHOSPHATE
TSP
TSPA
TSPC
antisal4
dri-tri | [EINECS(EC#)]
231-509-8 | [Molecular Formula]
Na3O4P | [MDL Number]
MFCD00003510 | [Molecular Weight]
163.94 | [MOL File]
7601-54-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
1340°C | [density ]
2.536 g/cm3(Temp: 17.5 °C) | [vapor pressure ]
0Pa@20°C | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
H2O: slightly soluble(lit.) | [form ]
Powder | [color ]
White | [Odor]
at 100.00?%. odorless | [PH]
10.95(1 mM solution);11.71(10 mM solution);12.12(100 mM solution) | [Water Solubility ]
Soluble in water. Insoluble in ethanol and carbon disulfide. | [Sensitive ]
Hygroscopic | [Merck ]
14,8662 | [Dielectric constant]
1.6（Ambient） | [InChI]
InChI=1S/3Na.H3O4P/c;;;1-5(2,3)4/h;;;(H3,1,2,3,4)/q3*+1;/p-3 | [InChIKey]
RYFMWSXOAZQYPI-UHFFFAOYSA-K | [SMILES]
[Na+].[Na+].[Na+].P([O-])([O-])([O-])=O | [Uses]
Trisodium Phosphate(7601-54-9) is an emulsifier and buffer that is strongly
alkaline, with a ph of 12. it is moderately soluble in water, with a
solubility of 14 g/100 ml at 25°c. it functions as an emulsifier in
processed cheese to improve texture. it maintains viscosity and pre-
vents phase separation in evaporated milk and is also found in cereals.
it is also termed trisodium orthophosphate, sodium phosphate
tribasic, and trisodium monophosphate.
| [CAS DataBase Reference]
7601-54-9(CAS DataBase Reference) | [EPA Substance Registry System]
7601-54-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 3262 8/PG 3
| [WGK Germany ]
1
| [RTECS ]
TC9490000
| [F ]
34 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
28352910 | [Safety Profile]
Moderately toxic by intravenous route. Mutation data reported. A strong, caustic material. When heated to decomposition it emits toxic fumes of Na2O and POx. See also PHOSPHATES. | [Hazardous Substances Data]
7601-54-9(Hazardous Substances Data) | [Toxicity]
LD50 skin in rabbit: > 300mg/kg |
| Hazard Information | Back Directory | [Hazard]
Toxic by ingestion, irritant to tissue. | [Description]
Trisodium phosphate (TSP,7601-54-9) is an inorganic salt used as industrial detergents, metal treatment and in toilet floor cleaners. TSP is pure cleaning power. Used as a water softener; for the treatment of boiler water; as a paint remover; in photographic developers; for tanning leather; for manufacturing paper; for clarifying sugar.
Also, it is a common laboratory reagent. Use to dissolve dirt, grease, and mildew from siding, decks, masonry, boats, campers. To prepare surfaces before painting or staining wash with TSP. Trisodium phosphate is an approved food additive in the U.S., European Union and other countries of the world. It may be added to foods and beverages or smoothies and green drinks. The primary function of trisodium phosphate is acidity regulation. It is commonly present in dry, extruded cereals. Together with other phosphates, it modifies cereal color, aids the cereal's flow through the extruder and provides phosphorus fortification. It is also commonly present in cheese sauces as an emulsifier. Trisodium phosphate is a strong chemical and can cause severe eye damage and can burn unprotected skin. Poisoning occurs if you swallow, breathe in, or spill large amounts of this substance on your skin.
| [Physical properties]
The dodecahydrate is a white or colorless hexagonal crystal; density 1.62 g/cm3; melts around 75°C on rapid heating; partially loses water of crystallization at 100°C; retains the last water molecule even at moderate ignition; soluble in water, about 28 g/100 mL at 20°C; the solution is strongly alkaline; the pH of a 0.1M solution 11.5; insoluble in alcohol. | [Definition]
ChEBI: Trisodium phosphate is a sodium phosphate. | [General Description]
Sodium phosphate is a colorless to white crystalline powder or granules. It is prepared by neutralization of phosphoric acid under controlled conditions with sodium hydroxide or sodium carbonate . | [Flammability and Explosibility]
Nonflammable(100%) | [Industrial uses]
Different salts of phosphoric and polyphosphoric acids are used in flotation. From this
fairly large family of reagents, sodium phosphate is the preferred species.
Trisodium phosphate is a white, crystalline substance highly soluble
in water. Neutralizing phosphoric acid with soda ash produces trisodium phosphate.
Mono- and disodium
phosphates are rarely used. | [Mechanism of action]
TSP is a tribasic orthophosphate with a pH of 10.0–12.0 in aqueous solution,
and overall alkalinity aids in its interaction with cell membrane lipids, resulting
in membrane leakage . TSP may also increase
the sensitivity of some microorganisms to nisin and lysozyme. |
| Questions and Answers (Q&A) | Back Directory | [Chemical Properties]
The dodecahydrate is a white or colorless hexagonal crystal; density 1.62 g/cm3 ; melts around 75°C on rapid heating; partially loses water of crystallization at 100°C; retains the last water molecule even at moderate ignition; soluble in water, about 28 g/100 mL at 20°C; the solution is strongly alkaline; the pH of a 0.1M solution 11.5; insoluble in alcohol.
| [Uses]
Trisodium phosphate (TSP,7601-54-9) is a cleaning agent, lubricant, food additive, stain remover and degreaser. It is an alkaline cleaning agent that has been used as a household cleaner for many years, but ecological problems have largely ended that practice, at least in the western world. Substitutes are not as effective, but the raw chemical can be bought in bulk to add to other detergents. It works by disrupting the bacterial cell membrane and causing the contents to leak out, though the exact mechanism is not fully elucidated (Oyarzabal, 2005). Trisodium phosphate solutions are approved for treatment of beef carcasses in the US Code of Federal Regulations (21 CFR 182.1778; FDA 2003).
By the end of the 20th century, many products that formerly contained TSP were manufactured with TSP substitutes, which consist mainly of sodium carbonate along with various admixtures of nonionic surfactants and a limited percentage of sodium phosphates. TSP is commonly used after cleaning with mineral spirits in order to remove hydrocarbon residues. TSP may be used with household chlorine bleach in the same solution without hazardous reactions. This mixture is particularly good for removing mildew, but is ineffective at permanently removing mold.
| [Preparation]
Trisodium phosphate may be prepared in two steps, first by adding a little excess of sodium carbonate to phosphoric acid and then boiling the solution to expel carbon dioxide. Sodium hydroxide is then added to the solution:
Na2CO3+ H3PO4→Na2HPO4+ CO2+ H2O
Na2HPO4+ NaOH →Na3PO4+ H2O
Alternatively, trisodium phosphate may be prepared by complete neutralization of phosphoric acid with sodium hydroxide, followed by evaporation and crystallization:
H3PO4+ 3NaOH →Na3PO4+ 3H2O
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