| Identification | More | [Name]
Azosemide | [CAS]
27589-33-9 | [Synonyms]
2-chloro-5-(1h-tetrazol-5-yl)-4-(2-thenylamino)benzenesulphonamide
2-CHLORO-5-(1H-TETRAZOL-5-YL)-4-((2-THIENYLMETHYL)AMINO)-BENZENESULFONAMIDE
AZOSEMIDE
2-chloro-5-(1h-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-benzenesulfonamid
2-chloro-5-(1h-tetrazol-5-yl)-n(sup4)-2-thenyl-sulfanilamid
2-chloro-5-(1h-tetrazol-5-yl)-n(sup4)-2-thenylsulfanilamide
5-(4’-chloro-5’-sulfamoyl-2’-thenylaminophenyl)-tetrazole
azosemid
ple1053
Azosemide(Chemical Name: 2-Chloro-5-(1h-Tertrazol-5-Yl)-N4-(2-Thenyl))
AZOSEMIDE HPLC
2-Chloro-5-(1H-tetrazol-5-y1)-4-[(2-thienylmethyl)amino]benzenesulfona-Mide
Diart
Diurapid
Luret
SK-110 | [EINECS(EC#)]
248-549-7 | [Molecular Formula]
C12H11ClN6O2S2 | [MDL Number]
MFCD00867321 | [Molecular Weight]
370.84 | [MOL File]
27589-33-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
218-221° | [Boiling point ]
221°C (rough estimate) | [density ]
1.6843 (rough estimate) | [refractive index ]
1.6100 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
3.58±0.10(Predicted) | [color ]
Crystals | [CAS DataBase Reference]
27589-33-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Azosemide is a high-ceiling diuretic similiar in structure and profile to furosemide, albeit somewhat less potent and less bioavailable. It is useful in the treatment of congestive heart failure and similar edematous conditions. | [Originator]
Boehringer Manheim (W. Germany) | [Uses]
Diuretic. | [Definition]
ChEBI: A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hyp
rtension. | [Manufacturing Process]
The 4-chloro-5-sulfamoyl-2-thenylaminobenzonitrile used as starting material
is obtained by the reaction of 4-chloro-2-fluoro-5-sutfamoyl-benzonitrile with
thenylamine in anhydrous tetrahydrofuran.
Then the 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)phenyltetrazole (MP 218°
to 221°C, yield 37% of theory) is obtained by the reaction of 4-chloro-5-
sulfamoyl-2-thenylaminobenzonitrite (MP 170° to 174°C) with sodium azide
and ammonium chloride, | [Brand name]
LURET | [Therapeutic Function]
Diuretic | [Safety Profile]
Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion andsubcutaneous routes. An experimental teratogen. Whenheated to decomposition it emits toxic fumes of Cl-, SOx,and NOx. |
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