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ChemicalBook--->CAS DataBase List--->1374666-32-6

1374666-32-6

1374666-32-6 Structure

1374666-32-6 Structure
IdentificationBack Directory
[Name]

Mal-PEG2-acid
[CAS]

1374666-32-6
[Synonyms]

Mal-PEG2-acid
Mal-NH-PEG2-acid
Mal-PEG2-CH2CH2COOH
Maleimide-PEG2-CH2CH2COOH
α-Maleimidyl-ω-propionyloxy poly(ethylene glycol)
3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid
3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid
Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-
[Molecular Formula]

C11H15NO6
[MDL Number]

MFCD23726620
[MOL File]

1374666-32-6.mol
[Molecular Weight]

257.24
Chemical PropertiesBack Directory
[Boiling point ]

455.7±35.0 °C(Predicted)
[density ]

1.329±0.06 g/cm3(Predicted)
[form ]

powder to crystal
[pka]

4.27±0.10(Predicted)
[color ]

White to Light yellow
[CAS DataBase Reference]

1374666-32-6
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P271-P261-P280
[HS Code ]

2942000090
Hazard InformationBack Directory
[Description]

Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
[Biological Activity]

Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis.
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Non-cleavable

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PEGs

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