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ChemicalBook--->CAS DataBase List--->660843-23-2

660843-23-2

660843-23-2 Structure

660843-23-2 Structure
IdentificationBack Directory
[Name]

1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione
[CAS]

660843-23-2
[Synonyms]

Mal-PEG2-NH2 (TFA)
1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione
O-(2-aminoethyl)-O'-(2-maleimidoethyl)ethylene glycol trifluoroacetate salt
1-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione 2,2,2-trifluoroacetate
[Molecular Formula]

C12H17F3N2O6
[MDL Number]

MFCD29041599
[MOL File]

660843-23-2.mol
[Molecular Weight]

342.27
Chemical PropertiesBack Directory
[form ]

Oil
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Biological Activity]

Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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