| Identification | More | [Name]
2,6-Diaminopyridine | [CAS]
141-86-6 | [Synonyms]
2,6-diamino-pyridin
Diaminopyridine
Pyridine, 2,6-diamino-
pyridine-2,6-diyldiamine
2 6-DIAMINOPYRIDINE 99+% &
2,6-Diaminopyridine,>98%
2,6-DAP
2,6-Diaminopyridine
2,6-Pyridinediamine
RODOL 26PYR
6-Amino-2(1H)-pyridinimine | [EINECS(EC#)]
205-507-2 | [Molecular Formula]
C5H7N3 | [MDL Number]
MFCD07375472 | [Molecular Weight]
109.13 | [MOL File]
141-86-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-white crystal powder/granuale | [Melting point ]
117-122 °C (lit.) | [Boiling point ]
285 °C (lit.) | [density ]
1.7110 (rough estimate) | [refractive index ]
1.5340 (estimate) | [Fp ]
155°C | [storage temp. ]
Store below +30°C. | [solubility ]
180g/l | [form ]
Flakes or Crystalline Powder | [pka]
6.13±0.24(Predicted) | [color ]
Beige to dark brown-gray | [PH]
>7 (H2O) | [Water Solubility ]
9.9 g/100 mL (20 ºC) | [Detection Methods]
HPLC,NMR | [BRN ]
108513 | [InChIKey]
VHNQIURBCCNWDN-UHFFFAOYSA-N | [LogP]
0.550 (est) | [CAS DataBase Reference]
141-86-6(CAS DataBase Reference) | [NIST Chemistry Reference]
2,6-Pyridinediamine(141-86-6) | [EPA Substance Registry System]
141-86-6(EPA Substance) |
| Questions And Answer | Back Directory | [Uses]
2,6-Diaminopyridine(141-86-6) can be used to synthesize pentamidine derivatives which show antitumor activities and DNA binding activities. It can also be used to synthesize N-monocarbamoyl derivatives of symmetrical diamines with antiviral activity. Its derivatives can be used as models of molecular sensor for nucleic acid base detection.
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| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R25:Toxic if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
3
| [RTECS ]
US7570000
| [F ]
9 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29333999 | [Safety Profile]
Poison by intravenous
and intraperitoneal routes. Mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx. |
| Hazard Information | Back Directory | [Description]
2,6-Diaminopyridine(141-86-6) is an important organic reagent with a wide range of uses. It can be used for fluorescence detection, 2,6-Diaminopyridine fluorescence method for the determination of certain aromatic primary amines. It can also be used to prepare 2,6-Diaminopyridine imprinted core-shell nanoparticles. A new method for the detection of diaminopyridine derivatives using molecularly imprinted electrochemical sensors has been established, which has been applied to the detection of 2,6-Diaminopyridine in hair dyes with good sensitivity and selectivity.
| [Chemical Properties]
Off-white crystal powder/granuale | [Preparation]
In a 600 mL autoclave equipped with a gas entrapment stirrer, a solution of 5 g CuI in 120 g aqueous ammonia (30% NH3 by weight) was added and mixed with 77 g ammonium acetate and 60 g of 2, 6-dichloropyridine. After purging with nitrogen, 24 g of liquid ammonia was added resulting in a pressure of about 150 psi (1.03 MPa). Subsequently, the reaction mixture was heated to 150°C for 8 h under stirring. Throughout the reaction, the pressure decreased from an initial pressure of 680 psi (4.69 MPa) to 450 psi (3.10 MPa). The reaction mixture was allowed to cool to room temperature, and the pressure was brought back to atmospheric pressure. Finally, 2,6-Diaminopyridine was obtained after purification.
 | [Toxicity evaluation]
2,6-Diaminopyridine was not mutagenic in Salmonella typhimurium strain TA98 in the
presence or absence of nonharman at 200 μg/plate. The mutagenicity of this
compound was not enhanced by rodent liver S-9 (Sugimura et al., 1982).
In another study, it was not mutagenic in S. typhimurium strain
TA98 without rodent liver S-9. However, it was mutagenic in the presence of rodent
liver S-9 (Takahashi & Ono, 1993).
This compound was not mutagenic in S. typhimurium strains TA98, TA100, and
TA1535 in the presence or absence of rodent liver S-9 (JETOC, 1997; Takahashi &
Ono, 1993)
It was mutagenic in S. typhimurium strain TA1537 in the presence
or absence of rodent liver S-9 (JETOC, 1997).
2,6-Diaminopyridine was not mutagenic in Escherichia coli strain WP2 uvrA in the
presence or absence of rodent liver S-9 (JETOC, 1997). |
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