Salmeterol synthesis
- Product Name:Salmeterol
- CAS Number:89365-50-4
- Molecular formula:C25H37NO4
- Molecular Weight:415.57
943969-38-8
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89365-50-4
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Yield:89365-50-4 98.5%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol at 40; under 3677.86 - 4413.43 Torr; for 2 h;
Steps:
8
Example-8: Preparation of Salmeterol Base [II]800 mL methanol and 100 g 2-(benzyl-(6-(4-phenylbutoxy)hexyl)amino)-l-(4- (benzyloxy)-3-(hydroxymethyl)phenyl)ethanol (III) were taken in dry hydrogenator at 35°C under' nitrogen atmosphere. 3 g of 10% Pd/C was added into the reaction mixture and hydrogen gas was purged at 5-6 Kg/cm2 hydrogen pressure at 40°C. The reaction mixture was maintained for 2 hour and cooled to 25°C. The reaction mixture was filtered and washed with 100 ml methanol. The filtrate was concentrated under vacuum at 60°C to obtain 68 g (98.5%) Salmeterol base as oily residue.
References:
WO2012/32546,2012,A2 Location in patent:Page/Page column 29
amino]methyl]-1,3-benzenedimethanol](/CAS/GIF/934842-69-0.gif)
934842-69-0
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94749-73-2
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97664-55-6
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89365-50-4
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3360-41-6
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89365-50-4
191 suppliers
$75.00/10mg