ChemicalBook CAS DataBase List PeraMpanel

PeraMpanel synthesis

5synthesis methods

Product Name:PeraMpanel
CAS Number:380917-97-5
Molecular formula:C23H15N3O
Molecular Weight:349.38

Perampanel is discontinued (DEA controlled substance). Perampanel is a selective noncompetitive antagonist of AMPA receptors, the major subtype of ionotropic glutamate receptors. Perampanel was found to be effective in the treatment of refractory partial-onset seizures in clinical trials.

Synthetic Routes

ROUTE 1

ROUTE 2

ROUTE 3

ROUTE 4

ROUTE 5

ROUTE 6

ROUTE 7

ROUTE 8

ROUTE 9

ROUTE 10

: Hibi, Shigeki; Ueno, Koshi; Nagato, Satoshi; Kawano, Koki; Ito, Koichi; Norimine, Yoshihiko; Takenaka, Osamu; Hanada, Takahisa; Yonaga, Masahiro. Discovery of 2-?(2-?Oxo-?1-?phenyl-?5-?pyridin-?2-?yl-?1,?2-?dihydropyridin-?3-?yl)?benzonitrile (Perampanel)?: A Novel, Noncompetitive α-?Amino-?3-?hydroxy-?5-?methyl-?4-?isoxazolepropanoic Acid (AMPA) Receptor Antagonist. Journal of Medicinal Chemistry. Volume 55. Issue 23. Pages 10584-10600. Journal; Online Computer File. (2012).

381248-06-2 Synthesis

5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one

381248-06-2
97 suppliers
$34.00/100mg

172732-52-4
255 suppliers
$19.00/1g

380917-97-5
141 suppliers
$79.00/5mg

Yield:380917-97-5 73%

Reaction Conditions:

with caesium carbonate;palladium dichloride in N,N-dimethyl-formamide at 80; for 6 h;Inert atmosphere;Suzuki-Miyaura Coupling;

References:

Hibi, Shigeki;Ueno, Koshi;Nagato, Satoshi;Kawano, Koki;Ito, Koichi;Norimine, Yoshihiko;Takenaka, Osamu;Hanada, Takahisa;Yonaga, Masahiro [Journal of Medicinal Chemistry,2012,vol. 55,# 23,p. 10584 - 10600]