3,5-Dimethoxypyridine synthesis

7synthesis methods

Product Name:3,5-Dimethoxypyridine
CAS Number:18677-48-0
Molecular formula:C7H9NO2
Molecular Weight:139.15

124-41-4 Synthesis

124-41-4
698 suppliers
$12.00/25g

84476-99-3 Synthesis

84476-99-3
277 suppliers
$8.00/1g

18677-48-0
120 suppliers
$20.00/100mg

Yield:18677-48-0 91%

Reaction Conditions:

with methanol at 135; for 0.25 h;microwave;

Steps:

To a vial charged with 2,5-difluoropyridine (127 mg, 1.1 mmol) was added a 25% solution of sodium methoxide in methanol (2 mL). Upon completion of addition, the reaction mixture was heated at 135 ⁰C under microwave conditions for 15 min. At the conclusion of this period, the reaction mixture was diluted with brine (5 mL) and extracted with EtOAc (3 x 5 mL). The combined extracts were dried over Na₂SO₄ and filtered. The volatiles were removed under reduced pressure to provide a residue. The residue was subjected to chromatography on silica gel eluting with 0 to 60% EtOAc/hexanes to provide Intermediate 23 as a yellow oil (139 mg, 91%). ¹H NMR (400 MHz, CDCl₃) δ ppm 3.80 (s, 6 H), 6.87 (t, J-2.20 Hz, 1 H), 7.78 (d, J=2.20 Hz, 2 H).

References:

BRISTOL-MYERS SQUIBB COMPANY WO2007/30582, 2007, A2 Location in patent:Page/Page column 88

FullText

124-41-4 Synthesis

124-41-4
698 suppliers
$12.00/25g

71902-33-5 Synthesis