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ChemicalBook CAS DataBase List N-Methylpiperidine
626-67-5

N-Methylpiperidine synthesis

14synthesis methods
-

Yield:626-67-5 95%

Reaction Conditions:

with methylamine

Steps:

1 Preparation of N-methylpiperidine
EXAMPLE 1 Preparation of N-methylpiperidine 280 ml/hour of a mixture which consisted of 1,040 g of pentane-1,5-diol and 310 g of methylamine and 10 g of 45% strength aqueous potassium hydroxide solution were passed, at 245° C., under a total pressure of 250 bar and under a hydrogen partial pressure of 120 bar, through a tube reactor which had a diameter of 3.2 cm and a height of 125 cm and contained a bed of 700 ml of the catalyst prepared above. N-methylpiperidine was obtained in 95% yield.

References:

BASF Aktiengesellschaft US4910304, 1990, A

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